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Camk2b calcium/calmodulin-dependent protein kinase II, beta [ Mus musculus (house mouse) ]

Gene ID: 12323, updated on 10-Oct-2019

Summary

Official Symbol
Camk2bprovided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase II, betaprovided by MGI
Primary source
MGI:MGI:88257
See related
Ensembl:ENSMUSG00000057897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaMKII
Expression
Biased expression in frontal lobe adult (RPKM 115.3), cortex adult (RPKM 97.8) and 5 other tissues See more
Orthologs

Genomic context

See Camk2b in Genome Data Viewer
Location:
11 A1; 11 3.89 cM
Exon count:
26
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5969629..6066357, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (5869645..5965751, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 11967 Neighboring gene glucokinase Neighboring gene YKT6 v-SNARE homolog (S. cerevisiae) Neighboring gene predicted gene, 46269 Neighboring gene NudC domain containing 3 Neighboring gene ribosomal protein S15A, pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC90738

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
structural constituent of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of meiosis involved in egg activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
inhibitory G protein-coupled receptor phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
calcium- and calmodulin-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit beta
Names
CaMK II
caM kinase II subunit beta
caMK-II subunit beta
NP_001167524.1
NP_001167525.1
NP_031621.3
XP_006514527.1
XP_006514528.1
XP_006514530.1
XP_006514532.1
XP_006514533.1
XP_006514538.1
XP_006514539.1
XP_006514540.1
XP_006514542.1
XP_017169726.1
XP_017169727.1
XP_017169728.1
XP_017169729.1
XP_017169730.1
XP_030101361.1
XP_030101362.1
XP_030101363.1
XP_030101364.1
XP_030101365.1
XP_030101366.1
XP_030101367.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174053.1NP_001167524.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 1

    See identical proteins and their annotated locations for NP_001167524.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AK046454, BC080273, CJ119973, CJ250260
    Consensus CDS
    CCDS48748.1
    UniProtKB/TrEMBL
    Q68EG2, Q8BL41
    Related
    ENSMUSP00000087925.3, ENSMUST00000090443.9
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:413540
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_001174054.1NP_001167525.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK046454, BC024803, CJ119973, CJ250260
    Consensus CDS
    CCDS48749.1
    UniProtKB/TrEMBL
    Q5SVI2, Q8BL41
    Related
    ENSMUSP00000105437.2, ENSMUST00000109812.8
    Conserved Domains (2) summary
    cd14086
    Location:12314
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:397524
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_007595.5NP_031621.3  calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_031621.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK046454, AK163698, BU504775, CJ119973, CJ250260
    Consensus CDS
    CCDS24411.1
    UniProtKB/Swiss-Prot
    P28652
    UniProtKB/TrEMBL
    Q8BL41
    Related
    ENSMUSP00000105438.2, ENSMUST00000109813.8
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:410537
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    5969629..6066357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245501.1XP_030101361.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X9

  2. XM_017314237.2XP_017169726.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3

  3. XM_006514470.4XP_006514533.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:494621
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  4. XM_006514464.3XP_006514527.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:535662
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  5. XM_017314238.2XP_017169727.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5

  6. XM_006514469.3XP_006514532.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X6

    Related
    ENSMUSP00000091046.5, ENSMUST00000093355.11
    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:495622
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  7. XM_006514467.3XP_006514530.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:510637
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  8. XM_006514465.3XP_006514528.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2

    See identical proteins and their annotated locations for XP_006514528.1

    UniProtKB/TrEMBL
    Q5SVJ0
    Related
    ENSMUSP00000019133.4, ENSMUST00000019133.10
    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:534661
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  9. XM_017314240.2XP_017169729.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:396523
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  10. XM_030245502.1XP_030101362.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X16

  11. XM_006514475.2XP_006514538.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X11

    See identical proteins and their annotated locations for XP_006514538.1

    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:395522
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  12. XM_017314239.2XP_017169728.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:411538
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  13. XM_006514477.2XP_006514540.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X13

    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:385512
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  14. XM_006514476.2XP_006514539.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X12

    See identical proteins and their annotated locations for XP_006514539.1

    UniProtKB/TrEMBL
    Q5SVI0
    Related
    ENSMUSP00000099120.2, ENSMUST00000101586.2
    Conserved Domains (3) summary
    smart00220
    Location:14272
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:386513
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  15. XM_030245507.1XP_030101367.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X21

  16. XM_030245506.1XP_030101366.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X20

  17. XM_030245503.1XP_030101363.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X17

  18. XM_030245505.1XP_030101365.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X19

  19. XM_030245504.1XP_030101364.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X18

  20. XM_017314241.2XP_017169730.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X14

  21. XM_006514479.3XP_006514542.1  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X15

    See identical proteins and their annotated locations for XP_006514542.1

    UniProtKB/TrEMBL
    Q5SVJ1
    Related
    ENSMUSP00000002817.5, ENSMUST00000002817.11
    Conserved Domains (2) summary
    cd14086
    Location:12303
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:371498
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
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