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RND2 Rho family GTPase 2 [ Homo sapiens (human) ]

Gene ID: 8153, updated on 3-May-2020

Summary

Official Symbol
RND2provided by HGNC
Official Full Name
Rho family GTPase 2provided by HGNC
Primary source
HGNC:HGNC:18315
See related
Ensembl:ENSG00000108830 MIM:601555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHN; RHO7; RhoN
Summary
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 14.7), testis (RPKM 13.8) and 5 other tissues See more
Orthologs

Genomic context

See RND2 in Genome Data Viewer
Location:
17q21.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43025231..43032041)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41177258..41184058)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene interferon induced protein 35 Neighboring gene vesicle amine transport 1 Neighboring gene BRCA1 DNA repair associated Neighboring gene ribosomal protein L21 pseudogene 4 Neighboring gene BRCA1 intronic recombination region Neighboring gene BRCA1 intron 2 regulatory region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoN
Names
CTD-3199J23.4
GTP-binding protein Rho7
ras homolog gene family, member N
rho-related GTP-binding protein Rho7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005440.5NP_005431.1  rho-related GTP-binding protein RhoN

    See identical proteins and their annotated locations for NP_005431.1

    Status: REVIEWED

    Source sequence(s)
    AC135721, BC094842, BU687800, DB502558
    Consensus CDS
    CCDS11452.1
    UniProtKB/Swiss-Prot
    P52198
    Related
    ENSP00000466680.1, ENST00000587250.4
    Conserved Domains (1) summary
    cd04173
    Location:7227
    Rnd2_Rho7; Rnd2/Rho7 GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43025231..43032041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525316.1XP_011523618.1  rho-related GTP-binding protein RhoN isoform X1

    See identical proteins and their annotated locations for XP_011523618.1

    Conserved Domains (2) summary
    smart00174
    Location:10182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd04173
    Location:7227
    Rnd2_Rho7; Rnd2/Rho7 GTPases
  2. XM_011525317.2XP_011523619.1  rho-related GTP-binding protein RhoN isoform X2

    See identical proteins and their annotated locations for XP_011523619.1

    Conserved Domains (1) summary
    cl21455
    Location:7199
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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