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RND2 Rho family GTPase 2 [ Homo sapiens (human) ]

Gene ID: 8153, updated on 25-Jan-2024

Summary

Official Symbol
RND2provided by HGNC
Official Full Name
Rho family GTPase 2provided by HGNC
Primary source
HGNC:HGNC:18315
See related
Ensembl:ENSG00000108830 MIM:601555; AllianceGenome:HGNC:18315
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHN; RHO7; RhoN
Summary
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 14.7), testis (RPKM 13.8) and 5 other tissues See more
Orthologs
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Genomic context

See RND2 in Genome Data Viewer
Location:
17q21.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43025231..43032041)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43883786..43890596)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41177248..41184058)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12233 Neighboring gene interferon induced protein 35 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8550 Neighboring gene vesicle amine transport 1 Neighboring gene Sharpr-MPRA regulatory region 8675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41195058-41195600 Neighboring gene BRCA1 DNA repair associated Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:41214996-41215531 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41224055-41224260 Neighboring gene ribosomal protein L21 pseudogene 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:41243136-41244335 Neighboring gene BRCA1 intronic recombination region Neighboring gene BRCA1 intron 2 regulatory region Neighboring gene BRCA1 promoter region Neighboring gene neighbor of BRCA1 lncRNA 2 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in collateral sprouting IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho-related GTP-binding protein RhoN
Names
CTD-3199J23.4
GTP-binding protein Rho7
ras homolog gene family, member N
rho-related GTP-binding protein Rho7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005440.5NP_005431.1  rho-related GTP-binding protein RhoN

    See identical proteins and their annotated locations for NP_005431.1

    Status: REVIEWED

    Source sequence(s)
    AC135721, BC094842, BU687800, DB502558
    Consensus CDS
    CCDS11452.1
    UniProtKB/Swiss-Prot
    A8K2D4, O00690, O00734, P52198, Q5U0P6, Q99535
    UniProtKB/TrEMBL
    Q59EN3
    Related
    ENSP00000466680.1, ENST00000587250.4
    Conserved Domains (1) summary
    cd04173
    Location:7227
    Rnd2_Rho7; Rnd2/Rho7 GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    43025231..43032041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525316.2XP_011523618.1  rho-related GTP-binding protein RhoN isoform X1

    See identical proteins and their annotated locations for XP_011523618.1

    UniProtKB/TrEMBL
    Q59EN3
    Conserved Domains (2) summary
    smart00174
    Location:10182
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd04173
    Location:7227
    Rnd2_Rho7; Rnd2/Rho7 GTPases
  2. XM_011525317.3XP_011523619.1  rho-related GTP-binding protein RhoN isoform X2

    See identical proteins and their annotated locations for XP_011523619.1

    UniProtKB/TrEMBL
    Q59EN3
    Conserved Domains (1) summary
    cl38936
    Location:7199
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    43883786..43890596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317440.1XP_054173415.1  rho-related GTP-binding protein RhoN isoform X1

    UniProtKB/TrEMBL
    Q59EN3
  2. XM_054317441.1XP_054173416.1  rho-related GTP-binding protein RhoN isoform X2

    UniProtKB/TrEMBL
    Q59EN3