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CALR calreticulin [ Homo sapiens (human) ]

Gene ID: 811, updated on 5-Jul-2020

Summary

Official Symbol
CALRprovided by HGNC
Official Full Name
calreticulinprovided by HGNC
Primary source
HGNC:HGNC:1455
See related
Ensembl:ENSG00000179218 MIM:109091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RO; CRT; SSA; cC1qR; HEL-S-99n
Summary
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]
Expression
Ubiquitous expression in thyroid (RPKM 564.2), placenta (RPKM 291.4) and 24 other tissues See more
Orthologs

Genomic context

See CALR in Genome Data Viewer
Location:
19p13.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (12938609..12944489)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13049414..13055304)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene FARSA antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7930 Neighboring gene CRISPRi-FlowFISH-validated RAD23A regulatory element Neighboring gene microRNA 6515 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene GADD45G interacting protein 1 Neighboring gene DAN domain BMP antagonist family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Myelofibrosis
MedGen: C0001815 OMIM: 254450 GeneReviews: Not available
Compare labs
Thrombocythemia 1
MedGen: C3277671 OMIM: 187950 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
NHGRI GWA Catalog
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with calreticulin (CALR) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with calreticulin (CALR) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
env The ubiquitous eukaryotic protein calreticulin binds to newly synthesized HIV-1 gp160, suggesting that calreticulin might act as a chaperone PubMed
Rev rev HIV-1 Rev interacting protein, calreticulin (CALR), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CALR is increased by RRE PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of calreticulin (CALR) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26680

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
androgen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
carbohydrate binding TAS
Traceable Author Statement
more info
PubMed 
chaperone binding TAS
Traceable Author Statement
more info
PubMed 
complement component C1q binding TAS
Traceable Author Statement
more info
PubMed 
hormone binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ATF6-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
antigen processing and presentation of peptide antigen via MHC class I TAS
Traceable Author Statement
more info
 
cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucocorticoid receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell cycle arrest IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of intracellular steroid hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of trophoblast cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptide antigen assembly with MHC class I protein complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of dendritic cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
PubMed 
protein folding in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein maturation by protein folding TAS
Traceable Author Statement
more info
PubMed 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein stabilization TAS
Traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to testosterone IEA
Inferred from Electronic Annotation
more info
 
sequestering of calcium ion TAS
Traceable Author Statement
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
MHC class I peptide loading complex IDA
Inferred from Direct Assay
more info
PubMed 
MHC class I peptide loading complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
cell surface TAS
Traceable Author Statement
more info
PubMed 
collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum quality control compartment IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
focal adhesion HDA PubMed 
integral component of lumenal side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
polysome IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calreticulin
Names
CRP55
ERp60
HACBP
Sicca syndrome antigen A (autoantigen Ro; calreticulin)
calregulin
endoplasmic reticulum resident protein 60
epididymis secretory sperm binding protein Li 99n
grp60

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029662.1 RefSeqGene

    Range
    5001..10891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_828

mRNA and Protein(s)

  1. NM_004343.4NP_004334.1  calreticulin precursor

    See identical proteins and their annotated locations for NP_004334.1

    Status: REVIEWED

    Source sequence(s)
    AC092069
    Consensus CDS
    CCDS12288.1
    UniProtKB/Swiss-Prot
    P27797
    UniProtKB/TrEMBL
    V9HW88
    Related
    ENSP00000320866.4, ENST00000316448.9
    Conserved Domains (1) summary
    pfam00262
    Location:23332
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    12938609..12944489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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