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Calr calreticulin [ Mus musculus (house mouse) ]

Gene ID: 12317, updated on 20-Jun-2024

Summary

Official Symbol
Calrprovided by MGI
Official Full Name
calreticulinprovided by MGI
Primary source
MGI:MGI:88252
See related
Ensembl:ENSMUSG00000003814 AllianceGenome:MGI:88252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRT; Calregulin
Summary
Enables calcium ion binding activity; carbohydrate binding activity; and mRNA binding activity. Involved in several processes, including cellular senescence; peptide antigen assembly with MHC class I protein complex; and protein stabilization. Acts upstream of or within cortical actin cytoskeleton organization; positive regulation of NIK/NF-kappaB signaling; and regulation of meiotic nuclear division. Located in endoplasmic reticulum; external side of plasma membrane; and extracellular space. Part of MHC class I peptide loading complex. Is expressed in several structures, including central nervous system; extraembryonic component; gut; placenta; and spleen. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; pancreatic ductal adenocarcinoma; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 574.7), genital fat pad adult (RPKM 279.2) and 28 other tissues See more
Orthologs
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Genomic context

See Calr in Genome Data Viewer
Location:
8 C3; 8 41.21 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85568717..85573560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84842088..84846931, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DAN domain family member 5, BMP antagonist Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene STARR-positive B cell enhancer ABC_E5027 Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene STARR-positive B cell enhancer ABC_E564 Neighboring gene predicted gene 5911 Neighboring gene phenylalanyl-tRNA synthetase, alpha subunit Neighboring gene microRNA 7069

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables complement component C1q complex binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cortical actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intracellular steroid hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide antigen assembly with MHC class I protein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide antigen assembly with MHC class I protein complex ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of MHC class I peptide loading complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum quality control compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle TAS
Traceable Author Statement
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calreticulin
Names
CRP55
ERp60
HACBP
endoplasmic reticulum resident protein 60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007591.3NP_031617.1  calreticulin precursor

    See identical proteins and their annotated locations for NP_031617.1

    Status: VALIDATED

    Source sequence(s)
    AK075605, AK160197, BB727203, BY291864
    Consensus CDS
    CCDS22479.1
    UniProtKB/Swiss-Prot
    P14211, Q3TVD2
    UniProtKB/TrEMBL
    B2MWM9, Q3UWP8
    Related
    ENSMUSP00000003912.7, ENSMUST00000003912.7
    Conserved Domains (1) summary
    pfam00262
    Location:23332
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85568717..85573560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)