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CALM3 calmodulin 3 [ Homo sapiens (human) ]

Gene ID: 808, updated on 24-Nov-2020

Summary

Official Symbol
CALM3provided by HGNC
Official Full Name
calmodulin 3provided by HGNC
Primary source
HGNC:HGNC:1449
See related
Ensembl:ENSG00000160014 MIM:114183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CaM; CALM; CAM1; CAM2; CAMB; PHKD; CPVT6; LQT16; PHKD3; CaMIII; HEL-S-72
Summary
This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in brain (RPKM 470.4), testis (RPKM 108.1) and 23 other tissues See more
Orthologs

Genomic context

See CALM3 in Genome Data Viewer
Location:
19q13.32
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46601074..46610782)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47104512..47114039)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPP5 tetratricopeptide repeat domain containing 1 Neighboring gene paraneoplastic antigen-like protein 8B Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 38 Neighboring gene prostaglandin I2 receptor Neighboring gene G protein subunit gamma 8 Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene DACT3 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
LONG QT SYNDROME 16
MedGen: CN263287 OMIM: 618782 GeneReviews: Not available
not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env The calmodulin-binding domains in HIV-1 gp160 are involved in Fas-mediated apoptosis PubMed
env The carboxyl-terminal domains (residues 768-788 and 826-854) of HIV-1 gp160 bind to calmodulin (CaM) PubMed
Envelope transmembrane glycoprotein gp41 env The carboxyl terminus (amino acid residues 768-788 and 828-855) of HIV-1 gp41 binds efficiently to purified calmodulin (CaM) and inhibits in vitro CaM-mediated stimulation of phosphodiesterase activity PubMed
env The fusion between CD4+ human cells and cells stably expressing HIV-1 gp41 and gp120 is inhibited by calmodulin PubMed
Nef nef HIV-1 Nef induces interleukin 10 expression through an interaction with the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway PubMed
nef HIV-1 Nef-induced CCL-2/MCP-1 upregulation in astrocytes depends on the myristoylation moiety (residues 2-3) of Nef and requires functional calmodulin PubMed
nef Fluorescence spectroscopy analyses indicate the myristoylated N-terminal eight amino acids of HIV-1 Nef directly interact with calcium bound calmodulin PubMed
matrix gag An HIV-1 MA peptide (residues 8-43) binds to CaM with a very high affinity with dissociation constant 25 nm PubMed
gag Calmodulin (CaM) binding to HIV-1 MA induces the extrusion of the myristate group, suggesting that hydrophobic contacts between CaM and MA are critical for binding PubMed
gag Calmodulin binds to both HIV-1 Gag and Matrix proteins through an extended calmodulin-binding domain in Matrix (amino acids 11-46) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-terminal myristoylation domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
adenylate cyclase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
nitric-oxide synthase binding IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase regulator activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
titin binding IPI
Inferred from Physical Interaction
more info
PubMed 
type 3 metabotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
activation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization to mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of high voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of ryanodine-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclic-nucleotide phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
Inferred by Curator
more info
 
regulation of cell communication by electrical coupling involved in cardiac conduction IC
Inferred by Curator
more info
 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development HEP PubMed 
Component Evidence Code Pubs
calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
catalytic complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
growth cone IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
vesicle HDA PubMed 
voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calmodulin-3
Names
Calmodulin-1
Calmodulin-2
epididymis secretory protein Li 72
phosphorylase kinase subunit delta
prepro-calmodulin 3
NP_001316850.1
NP_001316851.1
NP_001316852.1
NP_001316853.1
NP_001316854.1
NP_001316855.1
NP_005175.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051331.1 RefSeqGene

    Range
    5257..14709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329921.1NP_001316850.1  calmodulin-3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093503
    Consensus CDS
    CCDS86783.1
    UniProtKB/TrEMBL
    Q96HY3
    Related
    ENSP00000375785.2, ENST00000391918.6
    Conserved Domains (1) summary
    PTZ00184
    Location:1113
    PTZ00184; calmodulin; Provisional
  2. NM_001329922.1NP_001316851.1  calmodulin-3 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation from an alternate start codon compared to variant 1. Both variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC093503, AK295927, AL050207, BC005137, DC316124
    Consensus CDS
    CCDS86782.1
    UniProtKB/Swiss-Prot
    P0DP23, P0DP24, P0DP25
    UniProtKB/TrEMBL
    B4DJ51
    Related
    ENSP00000472141.1, ENST00000596362.1
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional
  3. NM_001329923.1NP_001316852.1  calmodulin-3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093503, AK310762, AL050207, BC005137
    Consensus CDS
    CCDS86783.1
    UniProtKB/Swiss-Prot
    P0DP25
    UniProtKB/TrEMBL
    Q96HY3
    Related
    ENSP00000471225.1, ENST00000599839.5
    Conserved Domains (1) summary
    PTZ00184
    Location:1113
    PTZ00184; calmodulin; Provisional
  4. NM_001329924.2NP_001316853.1  calmodulin-3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093503, AL050207, BC005137, BQ428612
    Consensus CDS
    CCDS86783.1
    UniProtKB/Swiss-Prot
    P0DP25
    UniProtKB/TrEMBL
    Q96HY3, Q9BRL5
    Conserved Domains (1) summary
    PTZ00184
    Location:1113
    PTZ00184; calmodulin; Provisional
  5. NM_001329925.2NP_001316854.1  calmodulin-3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093503, AL050207, BC005137, DC405050
    Consensus CDS
    CCDS86783.1
    UniProtKB/Swiss-Prot
    P0DP25
    UniProtKB/TrEMBL
    Q96HY3, Q9BRL5
    Related
    ENSP00000470502.1, ENST00000598871.5
    Conserved Domains (1) summary
    PTZ00184
    Location:1113
    PTZ00184; calmodulin; Provisional
  6. NM_001329926.2NP_001316855.1  calmodulin-3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093503, AL050207, BC005137, BC006182, DA138677
    Consensus CDS
    CCDS86783.1
    UniProtKB/Swiss-Prot
    P0DP25
    UniProtKB/TrEMBL
    Q96HY3, Q9BRL5
    Related
    ENSP00000468877.1, ENST00000594523.5
    Conserved Domains (1) summary
    PTZ00184
    Location:1113
    PTZ00184; calmodulin; Provisional
  7. NM_005184.4NP_005175.2  calmodulin-3 isoform 1

    See identical proteins and their annotated locations for NP_005175.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AW883334, BC005137, BC006182
    Consensus CDS
    CCDS33061.1
    UniProtKB/Swiss-Prot
    P0DP23, P0DP24, P0DP25
    UniProtKB/TrEMBL
    B4DJ51, Q9BRL5
    Related
    ENSP00000291295.8, ENST00000291295.14
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    46601074..46610782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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