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Calm3 calmodulin 3 [ Mus musculus (house mouse) ]

Gene ID: 12315, updated on 5-Apr-2024

Summary

Official Symbol
Calm3provided by MGI
Official Full Name
calmodulin 3provided by MGI
Primary source
MGI:MGI:103249
See related
Ensembl:ENSMUSG00000019370 AllianceGenome:MGI:103249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaMA; Cam3; Camc
Summary
Predicted to enable several functions, including N-terminal myristoylation domain binding activity; enzyme activator activity; and enzyme binding activity. Acts upstream of or within G2/M transition of mitotic cell cycle. Located in myelin sheath. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; familial hypertrophic cardiomyopathy; long QT syndrome 14; and long QT syndrome 15. Orthologous to human CALM1 (calmodulin 1); CALM2 (calmodulin 2); and CALM3 (calmodulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 496.4), frontal lobe adult (RPKM 463.0) and 28 other tissues See more
Orthologs
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Genomic context

See Calm3 in Genome Data Viewer
Location:
7 A2; 7 9.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16649304..16657957, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16915379..16924032, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), gamma 8 Neighboring gene prostaglandin I receptor (IP) Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17509453-17509640 Neighboring gene predicted gene, 45972 Neighboring gene predicted gene, 32630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:17529805-17530006 Neighboring gene PNMA family member 8B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenylate cyclase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables titin binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables type 3 metabotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
calmodulin-3
Names
caM
NP_031616.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007590.3NP_031616.1  calmodulin-3

    See identical proteins and their annotated locations for NP_031616.1

    Status: VALIDATED

    Source sequence(s)
    BC050926, BE853985
    Consensus CDS
    CCDS39789.1
    UniProtKB/Swiss-Prot
    P0DP26, P0DP27, P0DP28, P62204, Q3TEH7, Q3THK5, Q3U6Z5, Q3U7C7, Q498A3, Q8BNC9, Q91VQ9, Q9D6G4
    Related
    ENSMUSP00000019514.10, ENSMUST00000019514.10
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16649304..16657957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)