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Parp9 poly (ADP-ribose) polymerase family, member 9 [ Mus musculus (house mouse) ]

Gene ID: 80285, updated on 8-Feb-2024

Summary

Official Symbol
Parp9provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 9provided by MGI
Primary source
MGI:MGI:1933117
See related
Ensembl:ENSMUSG00000022906 AllianceGenome:MGI:1933117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bal; Bagl; ARTD9; PARP-9
Summary
Predicted to enable several functions, including ADP-D-ribose binding activity; STAT family protein binding activity; and pentosyltransferase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; immune system; nasal cavity; and urinary system. Orthologous to human PARP9 (poly(ADP-ribose) polymerase family member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 7.9), liver E18 (RPKM 7.8) and 26 other tissues See more
Orthologs
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Genomic context

See Parp9 in Genome Data Viewer
Location:
16 B3; 16 25.43 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35759360..35792975)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35938470..35972621)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41467 Neighboring gene STARR-seq mESC enhancer starr_40750 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4168 Neighboring gene deltex 3-like, E3 ubiquitin ligase Neighboring gene STARR-seq mESC enhancer starr_40752 Neighboring gene predicted gene 15564 Neighboring gene karyopherin subunit alpha 1 Neighboring gene STARR-positive B cell enhancer ABC_E5540 Neighboring gene WD repeat domain 5B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC7868

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP-D-ribose binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables STAT family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chromatin binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of type II interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type II interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in protein poly-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP9
Names
ADP-ribosyltransferase diphtheria toxin-like 9
b aggressive lymphoma protein homolog
poly [ADP-ribose] polymerase 9
NP_001392227.1
NP_001392228.1
NP_001392229.1
NP_001392230.1
NP_001392231.1
NP_001392232.1
NP_084529.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405298.1NP_001392227.1  protein mono-ADP-ribosyltransferase PARP9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC133464
  2. NM_001405299.1NP_001392228.1  protein mono-ADP-ribosyltransferase PARP9 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC133464
    UniProtKB/Swiss-Prot
    Q6IRT6, Q8CAS9, Q99LF9
  3. NM_001405300.1NP_001392229.1  protein mono-ADP-ribosyltransferase PARP9 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC133464
    UniProtKB/Swiss-Prot
    Q6IRT6, Q8CAS9, Q99LF9
  4. NM_001405301.1NP_001392230.1  protein mono-ADP-ribosyltransferase PARP9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133464
    UniProtKB/TrEMBL
    H7BWY5
  5. NM_001405302.1NP_001392231.1  protein mono-ADP-ribosyltransferase PARP9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133464
    UniProtKB/TrEMBL
    H7BWY5
    Related
    ENSMUSP00000023622.7, ENSMUST00000023622.13
  6. NM_001405303.1NP_001392232.1  protein mono-ADP-ribosyltransferase PARP9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133464
    UniProtKB/TrEMBL
    H7BWY5
  7. NM_030253.4NP_084529.1  protein mono-ADP-ribosyltransferase PARP9 isoform b

    See identical proteins and their annotated locations for NP_084529.1

    Status: VALIDATED

    Source sequence(s)
    AC133464
    Consensus CDS
    CCDS37326.1
    UniProtKB/Swiss-Prot
    Q8CAS9
    Related
    ENSMUSP00000110528.2, ENSMUST00000114878.8
    Conserved Domains (3) summary
    cd01439
    Location:673792
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:288422
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
    cd02907
    Location:83261
    Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    35759360..35792975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)