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PARP9 poly(ADP-ribose) polymerase family member 9 [ Homo sapiens (human) ]

Gene ID: 83666, updated on 6-Sep-2021

Summary

Official Symbol
PARP9provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 9provided by HGNC
Primary source
HGNC:HGNC:24118
See related
Ensembl:ENSG00000138496 MIM:612065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAL; BAL1; ARTD9; MGC:7868
Expression
Ubiquitous expression in spleen (RPKM 10.3), appendix (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

See PARP9 in Genome Data Viewer
Location:
3q21.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (122527924..122564784, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122246771..122283631, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene WDR5B divergent transcript Neighboring gene karyopherin subunit alpha 1 Neighboring gene uncharacterized LOC107984000 Neighboring gene uncharacterized LOC105374071 Neighboring gene deltex E3 ubiquitin ligase 3L Neighboring gene poly(ADP-ribose) polymerase family member 14 pseudogene Neighboring gene poly(ADP-ribose) polymerase family member 15 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A mega-analysis of genome-wide association studies for major depressive disorder.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of poly (ADP-ribose) polymerase family, member 9 (PARP9) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of poly (ADP-ribose) polymerase family, member 9 (PARP9) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26637, FLJ35310, FLJ41418, FLJ43593, DKFZp666B0810, DKFZp686M15238

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP-D-ribose binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
 
NOT enables NAD+ binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables STAT family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein ADP-ribosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin-like protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in NAD biosynthesis via nicotinamide riboside salvage pathway TAS
Traceable Author Statement
more info
 
involved_in cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chromatin binding IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of defense response to virus by host IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-gamma-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in posttranscriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein mono-ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT involved_in protein poly-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
involved_in viral protein processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP9
Names
ADP-ribosyltransferase diphtheria toxin-like 9
PARP-9
b aggressive lymphoma protein
poly (ADP-ribose) polymerase 9
poly [ADP-ribose] polymerase 9
NP_001139574.1
NP_001139575.1
NP_001139576.1
NP_001139577.1
NP_001139578.1
NP_001374800.1
NP_001374801.1
NP_001374802.1
NP_001374803.1
NP_001374804.1
NP_001374805.1
NP_001374806.1
NP_001374807.1
NP_001374808.1
NP_001374809.1
NP_001374810.1
NP_001374811.1
NP_001374812.1
NP_001374813.1
NP_001374814.1
NP_001374815.1
NP_001374816.1
NP_113646.2
XP_005247877.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146102.2NP_001139574.1  protein mono-ADP-ribosyltransferase PARP9 isoform a

    See identical proteins and their annotated locations for NP_001139574.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK313494, BC039580, DC368112
    Consensus CDS
    CCDS3014.1
    UniProtKB/Swiss-Prot
    Q8IXQ6
    Conserved Domains (3) summary
    cd01439
    Location:702821
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:310486
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:117277
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  2. NM_001146103.2NP_001139575.1  protein mono-ADP-ribosyltransferase PARP9 isoform b

    See identical proteins and their annotated locations for NP_001139575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    AC092908, AF307339, AL713679, BU675792, DB096326
    Consensus CDS
    CCDS54634.1
    UniProtKB/Swiss-Prot
    Q8IXQ6
    Related
    ENSP00000419506.1, ENST00000477522.6
    Conserved Domains (3) summary
    cd01439
    Location:667786
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  3. NM_001146104.2NP_001139576.1  protein mono-ADP-ribosyltransferase PARP9 isoform b

    See identical proteins and their annotated locations for NP_001139576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    BC039580, DC309545
    Consensus CDS
    CCDS54634.1
    UniProtKB/Swiss-Prot
    Q8IXQ6
    Related
    ENSP00000419001.1, ENST00000471785.5
    Conserved Domains (3) summary
    cd01439
    Location:667786
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  4. NM_001146105.2NP_001139577.1  protein mono-ADP-ribosyltransferase PARP9 isoform b

    See identical proteins and their annotated locations for NP_001139577.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 3, 4 and 5 encode the same isoform (b).
    Source sequence(s)
    BC039580, DC368112
    Consensus CDS
    CCDS54634.1
    UniProtKB/Swiss-Prot
    Q8IXQ6
    Related
    ENSP00000507390.1, ENST00000682323.1
    Conserved Domains (3) summary
    cd01439
    Location:667786
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  5. NM_001146106.3NP_001139578.1  protein mono-ADP-ribosyltransferase PARP9 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR and 3' coding region, compared to variant 1, which results in a frameshift. The encoded protein (isoform c) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AB209742, AC092908, AK092629, BC017463, BP259272
    Consensus CDS
    CCDS54633.1
    UniProtKB/TrEMBL
    Q59ER9
    Related
    ENSP00000418894.1, ENST00000462315.5
    Conserved Domains (3) summary
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:667695
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  6. NM_001387871.1NP_001374800.1  protein mono-ADP-ribosyltransferase PARP9 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd01439
    Location:702821
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:310486
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:117277
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  7. NM_001387872.1NP_001374801.1  protein mono-ADP-ribosyltransferase PARP9 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd01439
    Location:702821
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:310486
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:117277
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  8. NM_001387873.1NP_001374802.1  protein mono-ADP-ribosyltransferase PARP9 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd01439
    Location:680799
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:288464
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:95255
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  9. NM_001387874.1NP_001374803.1  protein mono-ADP-ribosyltransferase PARP9 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd01439
    Location:680799
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:288464
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:95255
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  10. NM_001387875.1NP_001374804.1  protein mono-ADP-ribosyltransferase PARP9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd01439
    Location:667786
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  11. NM_001387876.1NP_001374805.1  protein mono-ADP-ribosyltransferase PARP9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd01439
    Location:667786
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  12. NM_001387877.1NP_001374806.1  protein mono-ADP-ribosyltransferase PARP9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd01439
    Location:667786
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
  13. NM_001387878.1NP_001374807.1  protein mono-ADP-ribosyltransferase PARP9 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd02903
    Location:310486
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:117277
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:702729
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  14. NM_001387879.1NP_001374808.1  protein mono-ADP-ribosyltransferase PARP9 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd02903
    Location:310486
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:117277
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:702729
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  15. NM_001387880.1NP_001374809.1  protein mono-ADP-ribosyltransferase PARP9 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC092908
    Conserved Domains (3) summary
    cd02903
    Location:310486
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:117277
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:702730
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  16. NM_001387881.1NP_001374810.1  protein mono-ADP-ribosyltransferase PARP9 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:667694
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  17. NM_001387882.1NP_001374811.1  protein mono-ADP-ribosyltransferase PARP9 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:667694
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  18. NM_001387883.1NP_001374812.1  protein mono-ADP-ribosyltransferase PARP9 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:667694
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  19. NM_001387884.1NP_001374813.1  protein mono-ADP-ribosyltransferase PARP9 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
    Conserved Domains (3) summary
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:667694
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  20. NM_001387885.1NP_001374814.1  protein mono-ADP-ribosyltransferase PARP9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092908
    Conserved Domains (3) summary
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:667695
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  21. NM_001387886.1NP_001374815.1  protein mono-ADP-ribosyltransferase PARP9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092908
    Conserved Domains (3) summary
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:667695
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  22. NM_001387887.1NP_001374816.1  protein mono-ADP-ribosyltransferase PARP9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092908
    Conserved Domains (3) summary
    cd02903
    Location:275451
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:82242
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family
    cl00283
    Location:667695
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  23. NM_031458.3NP_113646.2  protein mono-ADP-ribosyltransferase PARP9 isoform a

    See identical proteins and their annotated locations for NP_113646.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC092908, AF307338, AL713679, BU675792, DB096326
    Consensus CDS
    CCDS3014.1
    UniProtKB/Swiss-Prot
    Q8IXQ6
    Related
    ENSP00000353512.2, ENST00000360356.6
    Conserved Domains (3) summary
    cd01439
    Location:702821
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:310486
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:117277
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family

RNA

  1. NR_170857.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
  2. NR_170858.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
  3. NR_170859.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
  4. NR_170860.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
  5. NR_170861.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
  6. NR_170862.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
  7. NR_170863.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908
  8. NR_170864.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861
  9. NR_170865.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092908, AC096861

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    122527924..122564784 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247820.2XP_005247877.1  protein mono-ADP-ribosyltransferase PARP9 isoform X1

    See identical proteins and their annotated locations for XP_005247877.1

    UniProtKB/Swiss-Prot
    Q8IXQ6
    Conserved Domains (3) summary
    cd01439
    Location:702821
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:310486
    Macro_BAL-like; macrodomain, B-aggressive lymphoma (BAL)-like family
    cd02907
    Location:117277
    Macro_Af1521_BAL-like; macrodomain, Af1521-like family

RNA

  1. XR_001740305.1 RNA Sequence

  2. XR_002959597.1 RNA Sequence

  3. XR_001740307.1 RNA Sequence

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