Conserved Protein Domain Family
Macro_BAL_like

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cd02903: Macro_BAL_like 
Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ADP-ribose as a ligand. Previously identified as displaying an Appr-1"-p (ADP-ribose-1"-monophosphate) processing activity, the macro domain may play roles in distinct ADP-ribose pathways, such as the ADP-ribosylation of proteins, an important post-translational modification which occurs in DNA repair, transcription, chromatin biology, and long-term memory formation, among other processes. Members of this family show similarity to BAL (B-aggressive lymphoma) proteins, which contain one to three macro domains. Most BAL family macro domains belong to this family except for the most N-terminal domain in multiple-domain containing proteins. Most BAL proteins also contain a C-terminal PARP active site and are also named as PARPs. Human BAL1 (or PARP-9) was originally identified as a risk-related gene in diffuse large B-cell lymphoma that promotes malignant B-cell migration. Some BAL family proteins exhibit PARP activity. Poly (ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins. BAL proteins may also function as transcription repressors.
Statistics
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PSSM-Id: 239231
View PSSM: cd02903
Aligned: 18 rows
Threshold Bit Score: 167.823
Threshold Setting Gi: 50750720
Created: 20-Sep-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative ADP-ribose binding site [chemical binding site]
Evidence:
  • Comment:by similarity to other members of this superfamily

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                ##            #       # ##                                              
gi 67078854   67 LNLKLISGDVLyiwADVIVNSVPMnlQLGGGPLSRAFLQKAGP----MLQKELDDRRRETee---------------kvG 127
gi 21757820   70 ITFQVATGDIAteqVDVIVNSTARt-FNRKSGVSRAILEGAGQ----AVESECAVLAAQPh------------------R 126
gi 47123187  356 MNLYLTKGYIEeqkTAVIVNSLGAnrNLNEGNISKAILRKAGNs---LSQEVLDKSKYVSp-----------------tD 415
gi 47215353  732 LRVVLCKGNIEdqrSCVIVNTISEtmNLDQGAVSRALLRAAGKglqaAVLKEARLARLDQld----------------pG 795
gi 47215353  938 LTFEVLSGDITretCDVIINSSNRd-FTLKSGVSKAILDGAGW----AVQVECAQQARAQgh---------------ppG 997
gi 47220223  101 LNIALATGKIEdatTDVIVNSVFKalNLKEGALSNAIFQAAGP----QLQVLLNAKKSSGt-----------------vG 159
gi 50750720 1142 VTLKVTSGDITkedTEVIVNIANQt-FDATSGVFKAIMDAAGF----DVKEECNQYGGLLq------------------S 1198
gi 50750722 1188 ITFQVAAGDITketGDVIVNISNQa-FNLKTGVSKAILEGAGK----EVENECAELEEAFvdrtelvngkpnewalqpnD 1262
gi 67078850 1064 IIFQVASGDITkeeADVIVNSTSNs-FNLKAGVSKAILECAGQ----NVERECSQQAQQRk------------------N 1120
gi 68367342   75 VTLEVSSGDITkekTDAIVNSSNPt-FSLKAGVSKAILDAAGG----QVVHECSQIVASSnk----------------qH 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                  # ###                 
gi 67078854  128 NIFMTSGCNLdCKAVLHAVAPYwnngaetswqiMANIIKKCLTTVEVlsFSSITFPMIGTGSLQFPKAVFAKLILSEVFE 207
gi 21757820  127 DFIITPGGCLkCKIIIHVPGGKd----------VRKTVTSVLEECEQrkYTSVSLPAIGTGNAGKNPITVADNIIDAIVD 196
gi 47123187  416 IMIPTRGYYLpCDFVYHVILQRsgsd---qkkiLKDGINACLNTALRynTSSISFPALGTGMLCFPKPVVAKVMTDEVLS 492
gi 47215353  796 SLLVTDGFKLrCQKVFHAVCPQwsasy-qaektLTSIISRCLKEAERlkMRSLSFPAIGTGLLSFPKDLVARVLLEEVRT 874
gi 47215353  998 HMIVTSAGRLpSKAIVHVSISNnp-------adIKSTVYAALKLCEEktFRSAAFPALGTGVGGVPPAAVADAMVGAVAD 1070
gi 47220223  160 DVIVTEGCQLkSMFVYHAVTPAkgtaqdqamkaLSGIFRDCLNKAEDrgMTSISFPTIGTGQLGFSKDHVAQVLYGEISK 239
gi 50750720 1199 GFITTKGGALlCRRIIHLIHSMn----------VKNQVSEVLHECQLrtYKSVAFPAIGTGAAQQSPAKVADDMLDAIVE 1268
gi 50750722 1263 GYITTEAGSLpCKKIIHFVARDd----------IKVPVSKVLQECELqqYTSVTFPAIGTGQAGRFPDLVADEMMDAITD 1332
gi 67078850 1121 DYIITGGGFLrCKNIIHVIGGNd----------VKSSVSSVLQECEKknYSSICLPAIGTGNAKQHPDKVAEAIIDAIED 1190
gi 68367342  134 REIVTSSGQLpCGKIIHISGCNgl-------stIKEVVLSVLKLCEShqFTSIAFPALGTGQGGVEPGDVADAMVDAVVN 206

                 .
Feature 1         
gi 67078854  208 Y 208
gi 21757820  197 F 197
gi 47123187  493 F 493
gi 47215353  875 F 875
gi 47215353 1071 F 1071
gi 47220223  240 F 240
gi 50750720 1269 F 1269
gi 50750722 1333 F 1333
gi 67078850 1191 F 1191
gi 68367342  207 F 207

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