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CALM1 calmodulin 1 [ Homo sapiens (human) ]

Gene ID: 801, updated on 5-Jul-2020

Summary

Official Symbol
CALM1provided by HGNC
Official Full Name
calmodulin 1provided by HGNC
Primary source
HGNC:HGNC:1442
See related
Ensembl:ENSG00000198668 MIM:114180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
caM; CAM2; CAM3; CAMB; CAMC; CAMI; PHKD; CPVT4; DD132; LQT14; CALML2; CAMIII
Summary
This gene encodes one of three calmodulin proteins which are members of the EF-hand calcium-binding protein family. Calcium-induced activation of calmodulin regulates and modulates the function of cardiac ion channels. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.A missense mutation in the CALM1 gene has been associated with ventricular tachycardia.[provided by RefSeq, May 2020]
Expression
Ubiquitous expression in brain (RPKM 439.8), esophagus (RPKM 93.6) and 24 other tissues See more
Orthologs

Genomic context

See CALM1 in Genome Data Viewer
Location:
14q32.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (90396502..90408275)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (90863327..90874619)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene proteasome 26S subunit, ATPase 1 Neighboring gene NRDE-2, necessary for RNA interference, domain containing Neighboring gene uncharacterized LOC105370618 Neighboring gene ribosomal protein L21 pseudogene 11 Neighboring gene Sharpr-MPRA regulatory region 5900 Neighboring gene Sharpr-MPRA regulatory region 3433 Neighboring gene long intergenic non-protein coding RNA 2317 Neighboring gene long intergenic non-protein coding RNA 642

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env The calmodulin-binding domains in HIV-1 gp160 are involved in Fas-mediated apoptosis PubMed
env The carboxyl-terminal domains (residues 768-788 and 826-854) of HIV-1 gp160 bind to calmodulin (CaM) PubMed
Envelope transmembrane glycoprotein gp41 env The carboxyl terminus (amino acid residues 768-788 and 828-855) of HIV-1 gp41 binds efficiently to purified calmodulin (CaM) and inhibits in vitro CaM-mediated stimulation of phosphodiesterase activity PubMed
env The fusion between CD4+ human cells and cells stably expressing HIV-1 gp41 and gp120 is inhibited by calmodulin PubMed
Nef nef HIV-1 Nef induces interleukin 10 expression through an interaction with the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway PubMed
nef HIV-1 Nef-induced CCL-2/MCP-1 upregulation in astrocytes depends on the myristoylation moiety (residues 2-3) of Nef and requires functional calmodulin PubMed
nef Interaction of HIV-1 Nef with calmodulin has been shown by coimmunoprecipitation analyses with lysates from NIH3T3 cells expressing Nef; a myristoylated 20 amino-acid peptide of Nef binds to calmodulin with higher affinity than the nonmyristoylated form PubMed
nef Fluorescence spectroscopy analyses indicate the myristoylated N-terminal eight amino acids of HIV-1 Nef directly interact with calcium bound calmodulin PubMed
Tat tat Calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK play a role in extracellular Tat-induced IL-10 expression in primary human monocytes PubMed
matrix gag HIV-1 MA-(8-43) binds to CaM in a manner similar to that observed for the full-length MA protein, and that the CaM protein is in an anti-parallel mode PubMed
gag An HIV-1 MA peptide (residues 8-43) binds to CaM with a very high affinity with dissociation constant 25 nm PubMed
gag The two buried tryptophan's (W16 and W36), which located in the first two alpha-helices of MA, mediate the calmodulin interaction PubMed
gag Calmodulin (CaM) binding to HIV-1 MA induces the extrusion of the myristate group, suggesting that hydrophobic contacts between CaM and MA are critical for binding PubMed
gag Calmodulin binds to both HIV-1 Gag and Matrix proteins through an extended calmodulin-binding domain in Matrix (amino acids 11-46) PubMed
retropepsin gag-pol Calcium-depleted calmodulin can be cleaved at phe65-pro66 and met71-met72 by HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-terminal myristoylation domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
adenylate cyclase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activator activity TAS
Traceable Author Statement
more info
PubMed 
titin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
MAPK cascade TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of calcium ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycogen catabolic process TAS
Traceable Author Statement
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle contraction TAS
Traceable Author Statement
more info
 
negative regulation of peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cyclic-nucleotide phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
Inferred by Curator
more info
 
regulation of cell communication by electrical coupling involved in cardiac conduction IC
Inferred by Curator
more info
 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
regulation of rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
substantia nigra development HEP PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
catalytic complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
vesicle HDA PubMed 

General protein information

Preferred Names
calmodulin-1
Names
Calmodulin-2
Calmodulin-3
calmodulin 1 (phosphorylase kinase, delta)
phosphorylase kinase subunit delta
phosphorylase kinase, delta subunit
prepro-calmodulin 1
NP_001350598.1
NP_001350599.1
NP_008819.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013338.1 RefSeqGene

    Range
    5047..16286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363669.1NP_001350598.1  calmodulin-1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL512791, DA059080
    Related
    ENSP00000442853.2, ENST00000544280.6
    Conserved Domains (1) summary
    PTZ00184
    Location:1113
    PTZ00184; calmodulin; Provisional
  2. NM_001363670.1NP_001350599.1  calmodulin-1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL512791
    Consensus CDS
    CCDS86421.1
    Conserved Domains (1) summary
    PTZ00184
    Location:3150
    PTZ00184; calmodulin; Provisional
  3. NM_006888.6NP_008819.1  calmodulin-1 isoform 2

    See identical proteins and their annotated locations for NP_008819.1

    Status: REVIEWED

    Source sequence(s)
    AI651063, AL512791, AU122722, BC011834
    Consensus CDS
    CCDS9892.1
    UniProtKB/Swiss-Prot
    P0DP23, P0DP24, P0DP25
    UniProtKB/TrEMBL
    B4DJ51
    Related
    ENSP00000349467.4, ENST00000356978.9
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    90396502..90408275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001166106.1: Suppressed sequence

    Description
    NM_001166106.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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