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Calm1 calmodulin 1 [ Mus musculus (house mouse) ]

Gene ID: 12313, updated on 7-Oct-2018

Summary

Official Symbol
Calm1provided by MGI
Official Full Name
calmodulin 1provided by MGI
Primary source
MGI:MGI:88251
See related
Ensembl:ENSMUSG00000001175 Vega:OTTMUSG00000016979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaM; Calm; Cam1; AI256814; AI327027; AI461935; AL024000
Summary
This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in cortex adult (RPKM 432.2), frontal lobe adult (RPKM 376.1) and 26 other tissues See more
Orthologs

Genomic context

See Calm1 in Genome Data Viewer
Location:
12; 12 E
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (100199435..100209824)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (101437751..101448016)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36263 Neighboring gene predicted gene 10433 Neighboring gene predicted gene, 40557 Neighboring gene predicted gene 10432 Neighboring gene tetratricopeptide repeat domain 7B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase regulator activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
type 3 metabotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
calmodulin-1
NP_001300863.1
NP_033920.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313934.1NP_001300863.1  calmodulin-1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC159633, AK145841, AW489089, BC054805
    Consensus CDS
    CCDS83995.1
    UniProtKB/Swiss-Prot
    P0DP26
    UniProtKB/TrEMBL
    Q3UKW2
    Related
    ENSMUSP00000001204.6, OTTMUSP00000018449, ENSMUST00000001204.6, OTTMUST00000041175
    Conserved Domains (2) summary
    PTZ00184
    Location:50197
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:133195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_009790.5NP_033920.1  calmodulin-1 isoform 2

    See identical proteins and their annotated locations for NP_033920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon resulting in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC159633, AK150978, AW489089, BC054805, BY294999
    Consensus CDS
    CCDS36523.1
    UniProtKB/Swiss-Prot
    P0DP26, P0DP27, P0DP28
    Related
    ENSMUSP00000105709.3, OTTMUSP00000018448, ENSMUST00000110082.10, OTTMUST00000041174
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

    Range
    100199435..100209824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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