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ZNF665 zinc finger protein 665 [ Homo sapiens (human) ]

Gene ID: 79788, updated on 23-Nov-2021

Summary

Official Symbol
ZNF665provided by HGNC
Official Full Name
zinc finger protein 665provided by HGNC
Primary source
HGNC:HGNC:25885
See related
Ensembl:ENSG00000197497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP160L
Expression
Ubiquitous expression in ovary (RPKM 1.8), thyroid (RPKM 1.0) and 23 other tissues See more
Orthologs
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Genomic context

See ZNF665 in Genome Data Viewer
Location:
19q13.42
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (53162424..53193404, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53665677..53696611, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 415 Neighboring gene zinc finger protein 347 Neighboring gene Sharpr-MPRA regulatory region 171 Neighboring gene zinc finger protein 415 pseudogene Neighboring gene zinc finger protein 818, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association study to identify genetic determinants of severe asthma.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353457.2NP_001340386.1  zinc finger protein 665 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Conserved Domains (3) summary
    COG5048
    Location:162550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  2. NM_001353458.2NP_001340387.1  zinc finger protein 665 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Conserved Domains (4) summary
    COG5048
    Location:192580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320340
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:640664
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001353459.2NP_001340388.1  zinc finger protein 665 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS46169.1
    Conserved Domains (5) summary
    COG5048
    Location:164552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:292312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:654676
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:748
    KRAB; KRAB box
    pfam13465
    Location:612636
    zf-H2C2_2; Zinc-finger double domain
  4. NM_024733.5NP_079009.3  zinc finger protein 665 isoform 3

    See identical proteins and their annotated locations for NP_079009.3

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS46169.1
    UniProtKB/Swiss-Prot
    Q9H7R5
    Related
    ENSP00000379702.2, ENST00000396424.5
    Conserved Domains (5) summary
    COG5048
    Location:164552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:292312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:654676
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:748
    KRAB; KRAB box
    pfam13465
    Location:612636
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    53162424..53193404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527325.3XP_011525627.1  zinc finger protein 665 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:2578
    KRAB; krueppel associated box
    COG5048
    Location:181569
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:309329
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:559581
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2564
    KRAB; KRAB box
    pfam13465
    Location:321345
    zf-H2C2_2; Zinc-finger double domain
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