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ZNF665 zinc finger protein 665 [ Homo sapiens (human) ]

Gene ID: 79788, updated on 8-Dec-2022

Summary

Official Symbol
ZNF665provided by HGNC
Official Full Name
zinc finger protein 665provided by HGNC
Primary source
HGNC:HGNC:25885
See related
Ensembl:ENSG00000197497 AllianceGenome:HGNC:25885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP160L
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.8), thyroid (RPKM 1.0) and 23 other tissues See more
Orthologs
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Genomic context

See ZNF665 in Genome Data Viewer
Location:
19q13.42
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53162424..53193358, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56244690..56272858, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53665677..53696611, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 415 Neighboring gene zinc finger protein 347 Neighboring gene Sharpr-MPRA regulatory region 171 Neighboring gene zinc finger protein 480-like Neighboring gene zinc finger protein 415 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14345

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353457.2NP_001340386.1  zinc finger protein 665 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Conserved Domains (3) summary
    COG5048
    Location:162550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
  2. NM_001353458.2NP_001340387.1  zinc finger protein 665 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Conserved Domains (4) summary
    COG5048
    Location:192580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320340
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:640664
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001353459.2NP_001340388.1  zinc finger protein 665 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS46169.1
    UniProtKB/Swiss-Prot
    A8K5T8
    Conserved Domains (5) summary
    COG5048
    Location:164552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:292312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:654676
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:748
    KRAB; KRAB box
    pfam13465
    Location:612636
    zf-H2C2_2; Zinc-finger double domain
  4. NM_024733.5NP_079009.3  zinc finger protein 665 isoform 3

    See identical proteins and their annotated locations for NP_079009.3

    Status: VALIDATED

    Source sequence(s)
    AC092070
    Consensus CDS
    CCDS46169.1
    UniProtKB/Swiss-Prot
    A8K5T8, Q9H7R5
    Related
    ENSP00000379702.2, ENST00000396424.5
    Conserved Domains (5) summary
    COG5048
    Location:164552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:292312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:654676
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:748
    KRAB; KRAB box
    pfam13465
    Location:612636
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    53162424..53193358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439451.1XP_047295407.1  zinc finger protein 665 isoform X6

    UniProtKB/TrEMBL
    A0A3Q5AD24
    Related
    ENSP00000469154.1, ENST00000600412.1
  2. XM_047439450.1XP_047295406.1  zinc finger protein 665 isoform X6

    UniProtKB/TrEMBL
    A0A3Q5AD24
  3. XM_047439448.1XP_047295404.1  zinc finger protein 665 isoform X4

  4. XM_011527325.4XP_011525627.1  zinc finger protein 665 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:2578
    KRAB; krueppel associated box
    COG5048
    Location:181569
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:309329
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:559581
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2564
    KRAB; KRAB box
    pfam13465
    Location:321345
    zf-H2C2_2; Zinc-finger double domain
  5. XM_047439449.1XP_047295405.1  zinc finger protein 665 isoform X5

  6. XM_047439446.1XP_047295402.1  zinc finger protein 665 isoform X2

    UniProtKB/Swiss-Prot
    A8K5T8
  7. XM_047439447.1XP_047295403.1  zinc finger protein 665 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    56244690..56272858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)