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NOX5 NADPH oxidase 5 [ Homo sapiens (human) ]

Gene ID: 79400, updated on 11-Sep-2019

Summary

Official Symbol
NOX5provided by HGNC
Official Full Name
NADPH oxidase 5provided by HGNC
Primary source
HGNC:HGNC:14874
See related
Ensembl:ENSG00000255346 MIM:606572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in spleen (RPKM 7.9), testis (RPKM 4.2) and 3 other tissues See more
Orthologs

Genomic context

See NOX5 in Genome Data Viewer
Location:
15q23
Exon count:
18
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (68930525..69062762)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69222839..69349501)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ANP32A intronic transcript 1 Neighboring gene acidic nuclear phosphoprotein 32 family member A Neighboring gene cytokine induced apoptosis inhibitor 1 pseudogene Neighboring gene sperm equatorial segment protein 1 Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) pseudogene Neighboring gene Ewing sarcoma associated transcript 1 Neighboring gene family with sequence similarity 47 member C pseudogene Neighboring gene glucuronic acid epimerase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 inhibits the cellular immune response and enhances oxidative stress mediated by NADPH oxidase PubMed
Tat tat PDGF-BB inhibits NADPH oxidase-mediated reactive oxygen species production induced by HIV-1 Tat and morphine treatment in neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Detoxification of Reactive Oxygen Species, organism-specific biosystem (from REACTOME)
    Detoxification of Reactive Oxygen Species, organism-specific biosystemReactive oxygen species such as superoxide (O2.-), peroxides (ROOR), singlet oxygen, peroxynitrite (ONOO-), and hydroxyl radical (OH.) are generated by cellular processes such as respiration (reviewe...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149776, MGC149777

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP binding NAS
Non-traceable Author Statement
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding NAS
Non-traceable Author Statement
more info
PubMed 
heme binding NAS
Non-traceable Author Statement
more info
PubMed 
proton channel activity IDA
Inferred from Direct Assay
more info
PubMed 
superoxide-generating NADPH oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide-generating NADPH oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to oxidative stress TAS
Traceable Author Statement
more info
 
cytokine secretion NAS
Non-traceable Author Statement
more info
PubMed 
cytoskeleton-dependent cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of fusion of sperm to egg plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
regulation of proton transport NAS
Non-traceable Author Statement
more info
PubMed 
superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide anion generation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NADPH oxidase 5
Names
NADPH oxidase, EF-hand calcium binding domain 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030464.1 RefSeqGene

    Range
    5001..131663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184779.2NP_001171708.1  NADPH oxidase 5 isoform 2

    See identical proteins and their annotated locations for NP_001171708.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, alternately referred to as NOX5 alpha and v1) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC027088, AF353088, AI091544, DA868876, DQ413001
    Consensus CDS
    CCDS53954.1
    UniProtKB/Swiss-Prot
    Q96PH1
    UniProtKB/TrEMBL
    A3QRJ0
    Related
    ENSP00000432440.2, ENST00000530406.6
    Conserved Domains (4) summary
    cd06186
    Location:420737
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd00051
    Location:97164
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:268374
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam13499
    Location:98162
    EF-hand_7; EF-hand domain pair
  2. NM_001184780.2NP_001171709.1  NADPH oxidase 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, alternately referred to as v6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC027088, AF325189, AI091544, BC125097, DA739867, DQ413001
    Consensus CDS
    CCDS53953.1
    UniProtKB/Swiss-Prot
    Q96PH1
    UniProtKB/TrEMBL
    A3QRJ0
    Related
    ENSP00000416828.3, ENST00000455873.7
    Conserved Domains (4) summary
    cd06186
    Location:413730
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd00051
    Location:90157
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:261367
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam13499
    Location:91155
    EF-hand_7; EF-hand domain pair
  3. NM_024505.4NP_078781.3  NADPH oxidase 5 isoform 1

    See identical proteins and their annotated locations for NP_078781.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, alternately referred to as NOX5 gamma and v3) encodes the longest isoform (1).
    Source sequence(s)
    AC027088, AF353089, AI091544, DA868876, DQ413001
    Consensus CDS
    CCDS32276.2
    UniProtKB/Swiss-Prot
    Q96PH1
    UniProtKB/TrEMBL
    A3QRJ0
    Related
    ENSP00000373518.3, ENST00000388866.8
    Conserved Domains (4) summary
    cd06186
    Location:448765
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd00051
    Location:97192
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:296402
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam13499
    Location:98190
    EF-hand_7; EF-hand domain pair

RNA

  1. NR_033671.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as NOX5 delta) contains two alternate 5' exons and lacks an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027088, AF325190, AI091544
  2. NR_033672.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as NOX5 beta) contains two alternate exons, lacks an alternate exon, and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027088, AF325189, AI091544, DQ413001
    Related
    ENST00000448182.7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    68930525..69062762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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