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SPESP1 sperm equatorial segment protein 1 [ Homo sapiens (human) ]

Gene ID: 246777, updated on 1-Jun-2020

Summary

Official Symbol
SPESP1provided by HGNC
Official Full Name
sperm equatorial segment protein 1provided by HGNC
Primary source
HGNC:HGNC:15570
See related
Ensembl:ENSG00000258484 MIM:609399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESP; SP-ESP
Summary
The encoded protein is a human alloantigen involved in sperm-egg binding and fusion. [provided by RefSeq, Apr 2010]
Expression
Biased expression in testis (RPKM 44.1), placenta (RPKM 5.7) and 4 other tissues See more
Orthologs

Genomic context

See SPESP1 in Genome Data Viewer
Location:
15q23
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (68930525..68946811)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69222839..69239150)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member A Neighboring gene ANP32A intronic transcript 1 Neighboring gene cytokine induced apoptosis inhibitor 1 pseudogene Neighboring gene NADPH oxidase 5 Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) pseudogene Neighboring gene Ewing sarcoma associated transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24663

Gene Ontology Provided by GOA

Process Evidence Code Pubs
acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
sperm-egg recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sperm equatorial segment protein 1
Names
equatorial segment protein
glycosylated 38 kDa sperm protein C-7/8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145658.4NP_663633.1  sperm equatorial segment protein 1 precursor

    See identical proteins and their annotated locations for NP_663633.1

    Status: REVIEWED

    Source sequence(s)
    AY358983, BC017998, BG720873
    Consensus CDS
    CCDS10230.1
    UniProtKB/Swiss-Prot
    Q6UW49
    Related
    ENSP00000312284.3, ENST00000310673.4
    Conserved Domains (1) summary
    pfam15754
    Location:21338
    SPESP1; Sperm equatorial segment protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    68930525..68946811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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