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Fgfr1 Fibroblast growth factor receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79114, updated on 22-May-2022

Summary

Official Symbol
Fgfr1provided by RGD
Official Full Name
Fibroblast growth factor receptor 1provided by RGD
Primary source
RGD:620713
See related
Ensembl:ENSRNOG00000016050 AllianceGenome:RGD:620713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to histamine; neuron development; and positive regulation of cell population proliferation. Located in nucleus; perinuclear region of cytoplasm; and plasma membrane. Used to study pulmonary hypertension. Biomarker of several diseases, including ischemia (multiple); mesangial proliferative glomerulonephritis; sciatic neuropathy; vascular dementia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); cleft lip; hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 185.8), Lung (RPKM 166.8) and 9 other tissues See more
Orthologs
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Genomic context

See Fgfr1 in Genome Data Viewer
Location:
16q12.4
Exon count:
21
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66492445..66546731, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71265390..71319046, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC120097430 Neighboring gene uncharacterized LOC120097442

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables fibroblast growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables fibroblast growth factor receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor-receptor interaction ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within auditory receptor cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to histamine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cementum mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ear development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development ISO
Inferred from Sequence Orthology
more info
 
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within generation of neurons ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung-associated mesenchyme development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within midbrain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within middle ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in motogenic signaling involved in postnatal olfactory bulb interneuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of fibroblast growth factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in orbitofrontal cortex development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within organ induction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outer ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within paraxial mesoderm development ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hepatic stellate cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of parathyroid hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of lateral mesodermal cell fate specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of phosphate transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of phosphorus metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to sodium phosphate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ureteric bud development ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular zone neuroblast division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vitamin D3 metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fibroblast growth factor receptor 1
Names
FGF receptor-1
FGFR-1
MFR
bFGF-R
bFGF-R-1
basic fibroblast growth factor receptor 1
c-fgr
proto-oncogene c-Fgr
NP_077060.1
XP_006253385.1
XP_006253386.1
XP_006253388.1
XP_006253389.1
XP_017455740.1
XP_017455741.1
XP_017455742.1
XP_017455743.1
XP_017455744.1
XP_038950778.1
XP_038950779.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024146.1NP_077060.1  fibroblast growth factor receptor 1 precursor

    See identical proteins and their annotated locations for NP_077060.1

    Status: PROVISIONAL

    Source sequence(s)
    D12498
    UniProtKB/Swiss-Prot
    Q04589
    Conserved Domains (6) summary
    cd05098
    Location:464765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:371400
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:255258
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:153247
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:255359
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    66492445..66546731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600251.2XP_017455740.1  fibroblast growth factor receptor 1 isoform X1

    Related
    ENSRNOP00000036885.5, ENSRNOT00000029284.5
    Conserved Domains (6) summary
    cd05098
    Location:464765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:371400
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:255258
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:153247
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:255359
    Ig; Immunoglobulin domain
  2. XM_006253327.2XP_006253389.1  fibroblast growth factor receptor 1 isoform X7

    See identical proteins and their annotated locations for XP_006253389.1

    UniProtKB/TrEMBL
    Q63827
    Conserved Domains (5) summary
    cd05098
    Location:371672
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:280309
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:164167
    Ig; Ig strand A [structural motif]
    cd05857
    Location:62156
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:164268
    Ig; Immunoglobulin domain
  3. XM_006253326.4XP_006253388.1  fibroblast growth factor receptor 1 isoform X6

    Related
    ENSRNOP00000043459.4, ENSRNOT00000050980.6
    Conserved Domains (5) summary
    cd05098
    Location:373674
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:280309
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:164167
    Ig; Ig strand A [structural motif]
    cd05857
    Location:62156
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:164268
    Ig; Immunoglobulin domain
  4. XM_017600254.2XP_017455743.1  fibroblast growth factor receptor 1 isoform X5

    Conserved Domains (5) summary
    cd05098
    Location:375676
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:282311
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:166169
    Ig; Ig strand A [structural motif]
    cd05857
    Location:64158
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:166270
    Ig; Immunoglobulin domain
  5. XM_039094851.1XP_038950779.1  fibroblast growth factor receptor 1 isoform X4

    Conserved Domains (6) summary
    cd05098
    Location:460761
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:253256
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:151245
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:253357
    Ig; Immunoglobulin domain
  6. XM_017600253.2XP_017455742.1  fibroblast growth factor receptor 1 isoform X2

    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
  7. XM_006253323.4XP_006253385.1  fibroblast growth factor receptor 1 isoform X3

    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
  8. XM_039094850.1XP_038950778.1  fibroblast growth factor receptor 1 isoform X1

    Conserved Domains (6) summary
    cd05098
    Location:464765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:371400
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:255258
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:153247
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:255359
    Ig; Immunoglobulin domain
  9. XM_006253324.4XP_006253386.1  fibroblast growth factor receptor 1 isoform X2

    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
  10. XM_017600255.2XP_017455744.1  fibroblast growth factor receptor 1 isoform X1

    Conserved Domains (6) summary
    cd05098
    Location:464765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:371400
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:255258
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:153247
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:255359
    Ig; Immunoglobulin domain
  11. XM_017600252.2XP_017455741.1  fibroblast growth factor receptor 1 isoform X1

    Conserved Domains (6) summary
    cd05098
    Location:464765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:371400
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:255258
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:153247
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:255359
    Ig; Immunoglobulin domain