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FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens (human) ]

Gene ID: 2260, updated on 21-Sep-2023

Summary

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Official Symbol
FGFR1provided by HGNC
Official Full Name
fibroblast growth factor receptor 1provided by HGNC
Primary source
HGNC:HGNC:3688
See related
Ensembl:ENSG00000077782 MIM:136350; AllianceGenome:HGNC:3688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1
Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 21.8), fat (RPKM 21.4) and 25 other tissues See more
Orthologs
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Genomic context

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See FGFR1 in Genome Data Viewer
Location:
8p11.23
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38411143..38468635, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38688107..38745588, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38268661..38326153, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene DDHD domain containing 2 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene NUP98-NSD3 recombination region Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38235530-38236031 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38238312-38238846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38239137-38239927 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38242638-38243268 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:38243269-38243898 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38244052-38244553 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38247000-38247501 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38248280-38248781 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38257600-38258101 Neighboring gene uncharacterized LOC102723716 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38261681-38262180 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38262831-38263332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38269931-38270603 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38270604-38271277 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38272896-38273666 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38274107-38274772 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38275681-38276444 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38277305-38277806 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38277908-38278453 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38278454-38278998 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38278999-38279544 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38279545-38280088 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38280202-38280702 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38280703-38281203 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38282951-38283642 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38285189-38286186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38287183-38288180 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38289284-38289961 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38289962-38290638 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38292133-38292640 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38292641-38293146 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38293147-38293653 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38294553-38295054 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38296366-38297156 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38297948-38298737 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38299529-38300319 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38298738-38299528 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38300320-38301110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38301111-38301900 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38303357-38303904 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38303905-38304451 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38308051-38308774 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38308775-38309498 Neighboring gene ribosomal protein S20 pseudogene 22 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38310223-38310946 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38312456-38313158 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38314169-38314670 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38315184-38316172 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38322798-38323299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38325893-38326879 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38329497-38330290 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38330291-38331084 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38331715-38332697 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38335294-38335795 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38337885-38338386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38342043-38342691 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38342692-38343339 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38343723-38344224 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38345990-38346491 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38347499-38348000 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38348154-38348655 Neighboring gene Sharpr-MPRA regulatory region 7766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38353597-38354164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38354165-38354733 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38359246-38360101 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38360102-38360956 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38360976-38361766 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38361767-38362556 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38368263-38369061 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:38369732-38370310 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:38370311-38370888 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38376955-38377456 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38379090-38380048 Neighboring gene long intergenic non-protein coding RNA 3042 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:38385147-38386346 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr8:38386932-38387753 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:38387754-38388574 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38388575-38389395 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38389396-38390215 Neighboring gene uncharacterized LOC124901935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38409783-38410284

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Significant association between FGFR1 mutation frequency and age in central giant cell granuloma. Niada S, et al. Pathology, 2023 Apr. PMID 36428107
  2. FGFR1 Antibody Validation and Characterization of FGFR1 Protein Expression in ER+ Breast Cancer. Gonzalez-Ericsson PI, et al. Appl Immunohistochem Mol Morphol, 2022 Oct 1. PMID 36083147,
  3. FGFR1 promotes tumor immune evasion via YAP-mediated PD-L1 expression upregulation in lung squamous cell carcinoma. Lu M, et al. Cell Immunol, 2022 Sep. PMID 35870429
  4. Rosette-forming glioneuronal tumours are midline, FGFR1-mutated tumours. Appay R, et al. Neuropathol Appl Neurobiol, 2022 Aug. PMID 35293634
  5. Evaluation of genome-wide association signals for nonsyndromic cleft lip with or without cleft palate in a multiethnic Brazilian population. Machado RA, et al. Arch Oral Biol, 2022 Mar. PMID 35151029

See all (731) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FGFR1 gene fusions in a subset of pediatric mesenchymal tumors: Expanding the genetic spectrum of tumors sharing histologic overlap with infantile fibrosarcoma and "NTRK-rearranged" spindle cell neoplasms.
    Title: FGFR1 gene fusions in a subset of pediatric mesenchymal tumors: Expanding the genetic spectrum of tumors sharing histologic overlap with infantile fibrosarcoma and "NTRK-rearranged" spindle cell neoplasms.
  2. Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion.
    Title: Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion.
  3. Myeloid/Lymphoid Neoplasm with FGFR1 Rearrangement Presenting with Polycythemia Vera and T-cell Acute Lymphoblastic Leukemia.
    Title: Myeloid/Lymphoid Neoplasm with FGFR1 Rearrangement Presenting with Polycythemia Vera and T-cell Acute Lymphoblastic Leukemia.
  4. Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS.
    Title: Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS.
  5. Significant association between FGFR1 mutation frequency and age in central giant cell granuloma.
    Title: Significant association between FGFR1 mutation frequency and age in central giant cell granuloma.
  6. Mutation spectrum of Kallmann syndrome: identification of five novel mutations across ANOS1 and FGFR1.
    Title: Mutation spectrum of Kallmann syndrome: identification of five novel mutations across ANOS1 and FGFR1.
  7. The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGFbeta-Induced Endothelial-to-Mesenchymal Transition.
    Title: The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGFβ-Induced Endothelial-to-Mesenchymal Transition.
  8. The FGFR1 Signaling Pathway Upregulates the Oncogenic Transcription Factor FOXQ1 to Promote Breast Cancer Cell Growth.
    Title: The FGFR1 Signaling Pathway Upregulates the Oncogenic Transcription Factor FOXQ1 to Promote Breast Cancer Cell Growth.
  9. Research on the variants of FGFR1 and CEP290 genes in idiopathic hypogonadotropin hypogonadism.
    Title: Research on the variants of FGFR1 and CEP290 genes in idiopathic hypogonadotropin hypogonadism.
  10. Aberrations in FGFR1, FGFR2, and RIP5 Expression in Human Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).
    Title: Aberrations in FGFR1, FGFR2, and RIP5 Expression in Human Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).
Submit: New GeneRIF Correction See all GeneRIFs (526)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Encephalocraniocutaneous lipomatosis
MedGen: C0406612 OMIM: 613001 GeneReviews: Encephalocraniocutaneous Lipomatosis
Compare labs
Hartsfield-Bixler-Demyer syndrome
MedGen: C1845146 OMIM: 615465 GeneReviews: Holoprosencephaly Overview, FGFR1-Related Hartsfield Syndrome
Compare labs
Hypogonadotropic hypogonadism 2 with or without anosmia
MedGen: C1563720 OMIM: 147950 GeneReviews: Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency
Compare labs
Jackson-Weiss syndrome
MedGen: C0795998 OMIM: 123150 GeneReviews: FGFR Craniosynostosis Syndromes Overview
Compare labs
Osteoglophonic dysplasia
MedGen: C0432283 OMIM: 166250 GeneReviews: Not available
Compare labs
Pfeiffer syndrome
MedGen: C0220658 OMIM: 101600 GeneReviews: FGFR Craniosynostosis Syndromes Overview
Compare labs
Trigonocephaly 1
MedGen: C0432122 OMIM: 190440 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-04-05)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-04-05)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of FGFR1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ99988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fibroblast growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables fibroblast growth factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fibroblast growth factor receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor-receptor interaction IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in chordate embryonic development TAS
Traceable Author Statement
more info
 PubMed 
involved_in epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in neuron migration TAS
Traceable Author Statement
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of phospholipase activity TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
Traceable Author Statement
more info
 PubMed 
involved_in skeletal system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in skeletal system morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fibroblast growth factor receptor 1
Names
FGFR1/PLAG1 fusion
FMS-like tyrosine kinase 2
basic fibroblast growth factor receptor 1
fms-related tyrosine kinase 2
heparin-binding growth factor receptor
hydroxyaryl-protein kinase
proto-oncogene c-Fgr
NP_001167534.1
NP_001167535.1
NP_001167536.1
NP_001167537.1
NP_001167538.1
NP_001341296.1
NP_001341297.1
NP_001341298.1
NP_001341299.1
NP_001397851.1
NP_056934.2
NP_075593.1
NP_075594.1
NP_075598.2
XP_006716366.1
XP_006716367.1
XP_006716370.1
XP_006716373.1
XP_006716374.1
XP_006716375.1
XP_006716377.1
XP_011542746.1
XP_011542747.1
XP_011542748.1
XP_011542749.1
XP_011542750.1
XP_011542751.1
XP_011542752.1
XP_011542753.1
XP_011542754.1
XP_016868708.1
XP_016868709.1
XP_016868710.1
XP_016868714.1
XP_016868715.1
XP_016868716.1
XP_016868720.1
XP_024302865.1
XP_047277525.1
XP_047277526.1
XP_047277528.1
XP_047277529.1
XP_047277530.1
XP_047277531.1
XP_047277532.1
XP_054216074.1
XP_054216075.1
XP_054216076.1
XP_054216077.1
XP_054216078.1
XP_054216079.1
XP_054216080.1
XP_054216081.1
XP_054216082.1
XP_054216083.1
XP_054216084.1
XP_054216085.1
XP_054216086.1
XP_054216087.1
XP_054216088.1
XP_054216089.1
XP_054216090.1
XP_054216091.1
XP_054216092.1
XP_054216093.1
XP_054216094.1
XP_054216095.1
XP_054216096.1
XP_054216097.1
XP_054216098.1
XP_054216099.1
XP_054216100.1
XP_054216101.1
XP_054216102.1
XP_054216103.1
XP_054216104.1
XP_054216105.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007729.1 RefSeqGene

    Range
    5001..62697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_993

mRNA and Protein(s)

  1. NM_001174063.2 → NP_001167534.1  fibroblast growth factor receptor 1 isoform 10 precursor

    See identical proteins and their annotated locations for NP_001167534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (10) lacks a 2-aa segment, compared to isoform 1.
    Source sequence(s)
    BC015035, FJ809917
    Consensus CDS
    CCDS55222.1
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    A0A0S2Z3Q6, A0A1B0RPQ4
    Related
    ENSP00000432972.1, ENST00000532791.5
    Conserved Domains (5) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163 → 247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:270 → 359
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:371 → 400
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

  2. NM_001174064.2 → NP_001167535.1  fibroblast growth factor receptor 1 isoform 11 precursor

    See identical proteins and their annotated locations for NP_001167535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) includes an alternate exon, uses an alternate translation start site, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (11) has a shorter and distinct N-terminus and lacks a 2-aa segment, compared to isoform 1.
    Source sequence(s)
    AB208919, FJ809917
    Consensus CDS
    CCDS55221.1
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    A0A1B0RPQ4
    Related
    ENSP00000337247.5, ENST00000335922.9
    Conserved Domains (7) summary
    cd04973
    Location:32 → 110
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:262 → 351
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155 → 239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:254 → 350
    IG_like; Immunoglobulin like
    pfam07679
    Location:152 → 239
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:454 → 755
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:468 → 744
    Pkinase_Tyr; Protein tyrosine kinase

  3. NM_001174065.2 → NP_001167536.1  fibroblast growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001167536.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2), also known as isoform A, III, and the 3-Ig domain form, lacks a 2-aa segment, compared to isoform 1. Both variants 2 and 12 encode the same isoform.z
    Source sequence(s)
    AK291754, AK292470, FJ809917
    Consensus CDS
    CCDS43732.1
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    A0A1B0RPQ4
    Related
    ENSP00000380302.2, ENST00000397113.6
    Conserved Domains (5) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161 → 245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268 → 357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

  4. NM_001174066.2 → NP_001167537.1  fibroblast growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001167537.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform.
    Source sequence(s)
    AK292470, FJ809917
    Consensus CDS
    CCDS43730.1
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    E7EU09
    Conserved Domains (5) summary
    cd05098
    Location:375 → 676
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:282 → 311
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:166 → 169
    Ig; Ig strand A [structural motif]
    cd05857
    Location:64 → 158
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:166 → 270
    Ig; Immunoglobulin domain

  5. NM_001174067.2 → NP_001167538.1  fibroblast growth factor receptor 1 isoform 14 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) represents use of an alternate promoter and 5' UTR, includes an alternate exon, uses an alternate translation start site, and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (14) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC087623, AK309947, FJ809917
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    A0A1B0RPQ4
    Conserved Domains (7) summary
    cd04973
    Location:73 → 151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301 → 390
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194 → 278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:293 → 389
    IG_like; Immunoglobulin like
    pfam07679
    Location:191 → 278
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:495 → 796
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:509 → 785
    Pkinase_Tyr; Protein tyrosine kinase

  6. NM_001354367.2 → NP_001341296.1  fibroblast growth factor receptor 1 isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623, AW206093
    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (6) summary
    cd05098
    Location:462 → 762
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:253 → 256
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25 → 118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:151 → 245
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:253 → 357
    Ig; Immunoglobulin domain

  7. NM_001354368.2 → NP_001341297.1  fibroblast growth factor receptor 1 isoform 16 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623, AW206093
    Consensus CDS
    CCDS94283.1
    UniProtKB/TrEMBL
    A0A0S2Z3T4, E7EU09
    Related
    ENSP00000507205.1, ENST00000684654.1
    Conserved Domains (5) summary
    cd05098
    Location:371 → 672
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:280 → 309
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:164 → 167
    Ig; Ig strand A [structural motif]
    cd05857
    Location:62 → 156
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:164 → 268
    Ig; Immunoglobulin domain

  8. NM_001354369.2 → NP_001341298.1  fibroblast growth factor receptor 1 isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623, AW206093
    Consensus CDS
    CCDS94284.1
    UniProtKB/TrEMBL
    A0A804HIF1, A0A8I3B1S4
    Related
    ENSP00000393312.4, ENST00000425967.8
    Conserved Domains (4) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161 → 245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268 → 357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:460 → 760
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

  9. NM_001354370.2 → NP_001341299.1  fibroblast growth factor receptor 1 isoform 18 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623, AW206093
    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (4) summary
    cd05857
    Location:72 → 156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:179 → 268
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:373 → 673
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:280 → 309
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

  10. NM_001410922.1 → NP_001397851.1  fibroblast growth factor receptor 1 isoform 19 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623
    Consensus CDS
    CCDS94285.1
    UniProtKB/TrEMBL
    A0A1B0RPQ4, A0A3B3ISD1
    Related
    ENSP00000497266.1, ENST00000649678.1

  11. NM_015850.4 → NP_056934.2  fibroblast growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_056934.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform A, III, and the 3-Ig domain form, lacks a 2-aa segment, compared to isoform 1. Both variants 2 and 12 encode the same isoform.
    Source sequence(s)
    AC087623, AK130555, AK222718, AW206093, BC018128, BQ774633, CX757985
    Consensus CDS
    CCDS43732.1
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    A0A1B0RPQ4
    Related
    ENSP00000380280.5, ENST00000397091.9
    Conserved Domains (5) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161 → 245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268 → 357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:462 → 763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

  12. NM_023105.3 → NP_075593.1  fibroblast growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_075593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform.
    Source sequence(s)
    AK130555, AW206093, BC018128, BQ774633, CX756209, CX757985, M34185
    Consensus CDS
    CCDS43730.1
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    E7EU09
    Related
    ENSP00000348537.5, ENST00000356207.9
    Conserved Domains (5) summary
    cd05098
    Location:375 → 676
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:282 → 311
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:166 → 169
    Ig; Ig strand A [structural motif]
    cd05857
    Location:64 → 158
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:166 → 270
    Ig; Immunoglobulin domain

  13. NM_023106.3 → NP_075594.1  fibroblast growth factor receptor 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_075594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses a different in-frame splice junction compared to variant 1. This variant encodes isoform 4, also known as isoform I, H3, and the 2-Ig Domain form, which is 91 aa shorter than isoform 1.
    Source sequence(s)
    AC087623, AK130555, AW206093, BC091494, BQ774633, CX757985, M37722
    Consensus CDS
    CCDS43731.1
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    E7EU09
    Related
    ENSP00000327229.6, ENST00000326324.10
    Conserved Domains (5) summary
    cd05098
    Location:373 → 674
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:280 → 309
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:164 → 167
    Ig; Ig strand A [structural motif]
    cd05857
    Location:62 → 156
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:164 → 268
    Ig; Immunoglobulin domain

  14. NM_023110.3 → NP_075598.2  fibroblast growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_075598.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1, also known as isoform Alpha A1, IV and the 3-Ig domain+2 AA insert form.
    Source sequence(s)
    AC087623, AK130555, AW206093, BC018128, BQ774633, CX757985, X66945
    Consensus CDS
    CCDS6107.2
    UniProtKB/Swiss-Prot
    A8K6T9, A8K8V5, C1KBH8, P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q53H63, Q59H40, Q5BJG2, Q8N685, Q9UD50, Q9UDF0, Q9UDF1, Q9UDF2
    UniProtKB/TrEMBL
    A0A1B0RPQ4
    Related
    ENSP00000400162.2, ENST00000447712.7
    Conserved Domains (6) summary
    cd05098
    Location:464 → 765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:371 → 400
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:255 → 258
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25 → 118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:153 → 247
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:255 → 359
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    38411143..38468635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716310.4 → XP_006716373.1  fibroblast growth factor receptor 1 isoform X19

    See identical proteins and their annotated locations for XP_006716373.1

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (6) summary
    cd04974
    Location:181 → 270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74 → 158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173 → 269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71 → 158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375 → 675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389 → 665
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_047421569.1 → XP_047277525.1  fibroblast growth factor receptor 1 isoform X9

    UniProtKB/TrEMBL
    A0A804HIF1, A0A8I3B1S4
    Related
    ENSP00000340636.7, ENST00000341462.9

  3. XM_006716303.4 → XP_006716366.1  fibroblast growth factor receptor 1 isoform X7

    See identical proteins and their annotated locations for XP_006716366.1

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (7) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270 → 359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163 → 247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262 → 358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160 → 247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:464 → 764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:478 → 754
    Pkinase_Tyr; Protein tyrosine kinase

  4. XM_047421574.1 → XP_047277530.1  fibroblast growth factor receptor 1 isoform X23

    UniProtKB/TrEMBL
    A0A0S2Z3T4, E7EU09

  5. XM_006716314.3 → XP_006716377.1  fibroblast growth factor receptor 1 isoform X20

    See identical proteins and their annotated locations for XP_006716377.1

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (4) summary
    cd05857
    Location:72 → 156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:179 → 268
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:373 → 673
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:280 → 309
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain

  6. XM_047421573.1 → XP_047277529.1  fibroblast growth factor receptor 1 isoform X22

    UniProtKB/TrEMBL
    A0A0S2Z3T9, E7EU09

  7. XM_006716311.1 → XP_006716374.1  fibroblast growth factor receptor 1 isoform X19

    See identical proteins and their annotated locations for XP_006716374.1

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (6) summary
    cd04974
    Location:181 → 270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74 → 158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173 → 269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71 → 158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375 → 675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389 → 665
    Pkinase_Tyr; Protein tyrosine kinase

  8. XM_006716307.2 → XP_006716370.1  fibroblast growth factor receptor 1 isoform X8

    See identical proteins and their annotated locations for XP_006716370.1

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (6) summary
    cd05098
    Location:462 → 762
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:253 → 256
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25 → 118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:151 → 245
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:253 → 357
    Ig; Immunoglobulin domain

  9. XM_047421570.1 → XP_047277526.1  fibroblast growth factor receptor 1 isoform X11

    UniProtKB/TrEMBL
    A0A0S2Z3Q6, A0A1B0RPQ4

  10. XM_006716304.2 → XP_006716367.1  fibroblast growth factor receptor 1 isoform X7

    See identical proteins and their annotated locations for XP_006716367.1

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (7) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270 → 359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163 → 247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262 → 358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160 → 247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:464 → 764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:478 → 754
    Pkinase_Tyr; Protein tyrosine kinase

  11. XM_017013221.2 → XP_016868710.1  fibroblast growth factor receptor 1 isoform X7

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (7) summary
    cd04973
    Location:40 → 118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270 → 359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163 → 247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262 → 358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160 → 247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:464 → 764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:478 → 754
    Pkinase_Tyr; Protein tyrosine kinase

  12. XM_047421572.1 → XP_047277528.1  fibroblast growth factor receptor 1 isoform X15

    UniProtKB/TrEMBL
    A0A804HIF1

  13. XM_017013227.2 → XP_016868716.1  fibroblast growth factor receptor 1 isoform X18

    UniProtKB/TrEMBL
    E7EU09

  14. XM_011544449.2 → XP_011542751.1  fibroblast growth factor receptor 1 isoform X14

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (6) summary
    cd04974
    Location:212 → 301
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:105 → 189
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:204 → 300
    IG_like; Immunoglobulin like
    pfam07679
    Location:102 → 189
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:406 → 706
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:420 → 696
    Pkinase_Tyr; Protein tyrosine kinase

  15. XM_011544450.3 → XP_011542752.1  fibroblast growth factor receptor 1 isoform X16

    UniProtKB/TrEMBL
    E7EU09
    Conserved Domains (6) summary
    cd04974
    Location:212 → 301
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:105 → 189
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:204 → 300
    IG_like; Immunoglobulin like
    pfam07679
    Location:102 → 189
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:406 → 707
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:420 → 696
    Pkinase_Tyr; Protein tyrosine kinase

  16. XM_017013226.2 → XP_016868715.1  fibroblast growth factor receptor 1 isoform X17

    UniProtKB/TrEMBL
    E7EU09

  17. XM_011544448.2 → XP_011542750.1  fibroblast growth factor receptor 1 isoform X13

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (6) summary
    cd04974
    Location:214 → 303
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:107 → 191
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:206 → 302
    IG_like; Immunoglobulin like
    pfam07679
    Location:104 → 191
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:408 → 708
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:422 → 698
    Pkinase_Tyr; Protein tyrosine kinase

  18. XM_017013219.2 → XP_016868708.1  fibroblast growth factor receptor 1 isoform X3

    UniProtKB/TrEMBL
    A0A804HIF1

  19. XM_017013220.2 → XP_016868709.1  fibroblast growth factor receptor 1 isoform X6

    UniProtKB/TrEMBL
    A0A1B0RPQ4

  20. XM_011544444.2 → XP_011542746.1  fibroblast growth factor receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (7) summary
    cd04973
    Location:73 → 151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301 → 390
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194 → 278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:293 → 389
    IG_like; Immunoglobulin like
    pfam07679
    Location:191 → 278
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:495 → 795
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:509 → 785
    Pkinase_Tyr; Protein tyrosine kinase

  21. XM_011544445.3 → XP_011542747.1  fibroblast growth factor receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (7) summary
    cd04973
    Location:73 → 151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303 → 392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196 → 280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:295 → 391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193 → 280
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:495 → 795
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:509 → 785
    Pkinase_Tyr; Protein tyrosine kinase

  22. XM_011544447.3 → XP_011542749.1  fibroblast growth factor receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A1B0RPQ4
    Conserved Domains (7) summary
    cd04973
    Location:73 → 151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303 → 392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196 → 280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:295 → 391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193 → 280
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:495 → 796
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:509 → 785
    Pkinase_Tyr; Protein tyrosine kinase

  23. XM_011544446.3 → XP_011542748.1  fibroblast growth factor receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A1B0RPQ4
    Conserved Domains (7) summary
    cd04973
    Location:73 → 151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303 → 392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196 → 280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:295 → 391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193 → 280
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:497 → 798
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:511 → 787
    Pkinase_Tyr; Protein tyrosine kinase

  24. XM_017013225.3 → XP_016868714.1  fibroblast growth factor receptor 1 isoform X12

    UniProtKB/TrEMBL
    A0A1B0RPQ4, A0A3B3ISD1
    Conserved Domains (6) summary
    cd05098
    Location:460 → 761
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam18123
    Location:369 → 398
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cd00096
    Location:253 → 256
    Ig; Ig strand A [structural motif]
    cd04973
    Location:25 → 118
    IgI_1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR); member of the I-set of Ig superfamily (IgSF) domains
    cd05857
    Location:151 → 245
    IgI_2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor; member of the I-set of IgSF domains
    cl11960
    Location:253 → 357
    Ig; Immunoglobulin domain

  25. XM_006716312.2 → XP_006716375.1  fibroblast growth factor receptor 1 isoform X19

    See identical proteins and their annotated locations for XP_006716375.1

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (6) summary
    cd04974
    Location:181 → 270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74 → 158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173 → 269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71 → 158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375 → 675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389 → 665
    Pkinase_Tyr; Protein tyrosine kinase

  26. XM_011544451.1 → XP_011542753.1  fibroblast growth factor receptor 1 isoform X21

    UniProtKB/TrEMBL
    E7EU09
    Conserved Domains (6) summary
    cd04974
    Location:173 → 262
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:66 → 150
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:165 → 261
    IG_like; Immunoglobulin like
    pfam07679
    Location:63 → 150
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:367 → 667
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:381 → 657
    Pkinase_Tyr; Protein tyrosine kinase

  27. XM_024447097.1 → XP_024302865.1  fibroblast growth factor receptor 1 isoform X10

    UniProtKB/TrEMBL
    A0A804HIF1
    Conserved Domains (4) summary
    cd04973
    Location:32 → 110
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155 → 239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:262 → 351
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:456 → 756
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

  28. XM_047421576.1 → XP_047277532.1  fibroblast growth factor receptor 1 isoform X25

    UniProtKB/TrEMBL
    E7EU09

  29. XM_047421575.1 → XP_047277531.1  fibroblast growth factor receptor 1 isoform X24

  30. XM_011544452.3 → XP_011542754.1  fibroblast growth factor receptor 1 isoform X27

    Conserved Domains (5) summary
    cd04973
    Location:73 → 151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301 → 387
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194 → 278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:293 → 387
    IG_like; Immunoglobulin like
    pfam07679
    Location:191 → 278
    I-set; Immunoglobulin I-set domain

  31. XM_017013231.2 → XP_016868720.1  fibroblast growth factor receptor 1 isoform X26

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    38688107..38745588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360126.1 → XP_054216101.1  fibroblast growth factor receptor 1 isoform X19

    UniProtKB/TrEMBL
    A0A804HIF1

  2. XM_054360109.1 → XP_054216084.1  fibroblast growth factor receptor 1 isoform X9

    UniProtKB/TrEMBL
    A0A804HIF1, A0A8I3B1S4

  3. XM_054360113.1 → XP_054216088.1  fibroblast growth factor receptor 1 isoform X7

    UniProtKB/TrEMBL
    A0A804HIF1

  4. XM_054360125.1 → XP_054216100.1  fibroblast growth factor receptor 1 isoform X23

    UniProtKB/TrEMBL
    A0A0S2Z3T4, E7EU09

  5. XM_054360122.1 → XP_054216097.1  fibroblast growth factor receptor 1 isoform X20

    UniProtKB/TrEMBL
    A0A804HIF1

  6. XM_054360124.1 → XP_054216099.1  fibroblast growth factor receptor 1 isoform X22

    UniProtKB/TrEMBL
    A0A0S2Z3T9, E7EU09

  7. XM_054360120.1 → XP_054216095.1  fibroblast growth factor receptor 1 isoform X19

    UniProtKB/TrEMBL
    A0A804HIF1

  8. XM_054360108.1 → XP_054216083.1  fibroblast growth factor receptor 1 isoform X8

    UniProtKB/TrEMBL
    A0A804HIF1

  9. XM_054360111.1 → XP_054216086.1  fibroblast growth factor receptor 1 isoform X11

    UniProtKB/TrEMBL
    A0A0S2Z3Q6, A0A1B0RPQ4

  10. XM_054360106.1 → XP_054216081.1  fibroblast growth factor receptor 1 isoform X7

    UniProtKB/TrEMBL
    A0A804HIF1

  11. XM_054360107.1 → XP_054216082.1  fibroblast growth factor receptor 1 isoform X7

    UniProtKB/TrEMBL
    A0A804HIF1

  12. XM_054360116.1 → XP_054216091.1  fibroblast growth factor receptor 1 isoform X15

    UniProtKB/TrEMBL
    A0A804HIF1

  13. XM_054360119.1 → XP_054216094.1  fibroblast growth factor receptor 1 isoform X18

    UniProtKB/TrEMBL
    E7EU09

  14. XM_054360115.1 → XP_054216090.1  fibroblast growth factor receptor 1 isoform X14

    UniProtKB/TrEMBL
    A0A804HIF1

  15. XM_054360117.1 → XP_054216092.1  fibroblast growth factor receptor 1 isoform X16

    UniProtKB/TrEMBL
    E7EU09

  16. XM_054360118.1 → XP_054216093.1  fibroblast growth factor receptor 1 isoform X17

    UniProtKB/TrEMBL
    E7EU09

  17. XM_054360114.1 → XP_054216089.1  fibroblast growth factor receptor 1 isoform X13

    UniProtKB/TrEMBL
    A0A804HIF1

  18. XM_054360102.1 → XP_054216077.1  fibroblast growth factor receptor 1 isoform X3

    UniProtKB/TrEMBL
    A0A804HIF1

  19. XM_054360105.1 → XP_054216080.1  fibroblast growth factor receptor 1 isoform X6

    UniProtKB/TrEMBL
    A0A1B0RPQ4

  20. XM_054360101.1 → XP_054216076.1  fibroblast growth factor receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0A804HIF1

  21. XM_054360100.1 → XP_054216075.1  fibroblast growth factor receptor 1 isoform X1

    UniProtKB/TrEMBL
    A0A804HIF1

  22. XM_054360104.1 → XP_054216079.1  fibroblast growth factor receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A1B0RPQ4

  23. XM_054360099.1 → XP_054216074.1  fibroblast growth factor receptor 1 isoform X28

    UniProtKB/TrEMBL
    A0A804HIF1

  24. XM_054360103.1 → XP_054216078.1  fibroblast growth factor receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A1B0RPQ4

  25. XM_054360112.1 → XP_054216087.1  fibroblast growth factor receptor 1 isoform X12

    UniProtKB/TrEMBL
    A0A1B0RPQ4, A0A3B3ISD1

  26. XM_054360121.1 → XP_054216096.1  fibroblast growth factor receptor 1 isoform X19

    UniProtKB/TrEMBL
    A0A804HIF1

  27. XM_054360123.1 → XP_054216098.1  fibroblast growth factor receptor 1 isoform X21

    UniProtKB/TrEMBL
    E7EU09

  28. XM_054360110.1 → XP_054216085.1  fibroblast growth factor receptor 1 isoform X10

    UniProtKB/TrEMBL
    A0A804HIF1

  29. XM_054360128.1 → XP_054216103.1  fibroblast growth factor receptor 1 isoform X25

    UniProtKB/TrEMBL
    E7EU09

  30. XM_054360127.1 → XP_054216102.1  fibroblast growth factor receptor 1 isoform X24

  31. XM_054360130.1 → XP_054216105.1  fibroblast growth factor receptor 1 isoform X27

  32. XM_054360129.1 → XP_054216104.1  fibroblast growth factor receptor 1 isoform X26

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023107.2: Suppressed sequence

    Description
    NM_023107.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_023108.2: Suppressed sequence

    Description
    NM_023108.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  3. NM_023109.1: Suppressed sequence

    Description
    NM_023109.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  4. NM_023111.2: Suppressed sequence

    Description
    NM_023111.2: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.

  5. NM_032191.1: Suppressed sequence

    Description
    NM_032191.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11362.3 GenPept UniProtKB/Swiss-Prot:P11362

Gene LinkOut

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