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FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens (human) ]

Gene ID: 2260, updated on 8-May-2020

Summary

Official Symbol
FGFR1provided by HGNC
Official Full Name
fibroblast growth factor receptor 1provided by HGNC
Primary source
HGNC:HGNC:3688
See related
Ensembl:ENSG00000077782 MIM:136350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1
Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 21.8), fat (RPKM 21.4) and 25 other tissues See more
Orthologs

Genomic context

See FGFR1 in Genome Data Viewer
Location:
8p11.23
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (38411138..38468834, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38268656..38326352, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene NUP98-NSD3 recombination region Neighboring gene uncharacterized LOC102723716 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene ribosomal protein S20 pseudogene 22 Neighboring gene Sharpr-MPRA regulatory region 13 Neighboring gene chromosome 8 open reading frame 86 Neighboring gene uncharacterized LOC105379383

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of FGFR1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor-receptor interaction IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
auditory receptor cell development IEA
Inferred from Electronic Annotation
more info
 
branching involved in salivary gland morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell migration TAS
Traceable Author Statement
more info
PubMed 
chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
chordate embryonic development TAS
Traceable Author Statement
more info
PubMed 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
lung-associated mesenchyme development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
middle ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of fibroblast growth factor production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
neuron migration TAS
Traceable Author Statement
more info
PubMed 
organ induction IEA
Inferred from Electronic Annotation
more info
 
outer ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
paraxial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle DNA replication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of parathyroid hormone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phospholipase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation TAS
Traceable Author Statement
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
Traceable Author Statement
more info
PubMed 
regulation of lateral mesodermal cell fate specification IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphate transport IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
skeletal system morphogenesis TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ureteric bud development IEA
Inferred from Electronic Annotation
more info
 
ventricular zone neuroblast division IEA
Inferred from Electronic Annotation
more info
 
vitamin D3 metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor receptor 1
Names
FGFR1/PLAG1 fusion
FMS-like tyrosine kinase 2
basic fibroblast growth factor receptor 1
fms-related tyrosine kinase 2
heparin-binding growth factor receptor
hydroxyaryl-protein kinase
proto-oncogene c-Fgr
NP_001167534.1
NP_001167535.1
NP_001167536.1
NP_001167537.1
NP_001167538.1
NP_001341296.1
NP_001341297.1
NP_001341298.1
NP_001341299.1
NP_056934.2
NP_075593.1
NP_075594.1
NP_075598.2
XP_006716366.1
XP_006716367.1
XP_006716370.1
XP_006716373.1
XP_006716374.1
XP_006716375.1
XP_006716377.1
XP_011542745.1
XP_011542746.1
XP_011542747.1
XP_011542748.1
XP_011542749.1
XP_011542750.1
XP_011542751.1
XP_011542752.1
XP_011542753.1
XP_011542754.1
XP_016868708.1
XP_016868709.1
XP_016868710.1
XP_016868711.1
XP_016868713.1
XP_016868714.1
XP_016868715.1
XP_016868716.1
XP_016868718.1
XP_016868719.1
XP_016868720.1
XP_024302865.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007729.1 RefSeqGene

    Range
    5001..62697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_993

mRNA and Protein(s)

  1. NM_001174063.2NP_001167534.1  fibroblast growth factor receptor 1 isoform 10 precursor

    See identical proteins and their annotated locations for NP_001167534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (10) lacks a 2-aa segment, compared to isoform 1.
    Source sequence(s)
    BC015035, FJ809917
    Consensus CDS
    CCDS55222.1
    UniProtKB/Swiss-Prot
    P11362
    UniProtKB/TrEMBL
    A0A0S2Z3Q6
    Related
    ENSP00000432972.1, ENST00000532791.5
    Conserved Domains (4) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:270359
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  2. NM_001174064.2NP_001167535.1  fibroblast growth factor receptor 1 isoform 11 precursor

    See identical proteins and their annotated locations for NP_001167535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) includes an alternate exon, uses an alternate translation start site, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (11) has a shorter and distinct N-terminus and lacks a 2-aa segment, compared to isoform 1.
    Source sequence(s)
    AB208919, FJ809917
    Consensus CDS
    CCDS55221.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000337247.5, ENST00000335922.9
    Conserved Domains (7) summary
    cd04973
    Location:32110
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:262351
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:254350
    IG_like; Immunoglobulin like
    pfam07679
    Location:152239
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:454755
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:468744
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_001174065.2NP_001167536.1  fibroblast growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001167536.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2), also known as isoform A, III, and the 3-Ig domain form, lacks a 2-aa segment, compared to isoform 1. Both variants 2 and 12 encode the same isoform.z
    Source sequence(s)
    AK291754, AK292470, FJ809917
    Consensus CDS
    CCDS43732.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000380302.2, ENST00000397113.6
    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_001174066.2NP_001167537.1  fibroblast growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001167537.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) represents use of an alternate promoter and 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform.
    Source sequence(s)
    AK292470, FJ809917
    Consensus CDS
    CCDS43730.1
    UniProtKB/Swiss-Prot
    P11362
    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375676
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
  5. NM_001174067.1NP_001167538.1  fibroblast growth factor receptor 1 isoform 14 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) represents use of an alternate promoter and 5' UTR, includes an alternate exon, uses an alternate translation start site, and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (14) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC087623, AK292470, AK309947, FJ809917
    Consensus CDS
    CCDS55223.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000393312.3, ENST00000425967.7
    Conserved Domains (7) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301390
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:293389
    IG_like; Immunoglobulin like
    pfam07679
    Location:191278
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:495796
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:509785
    Pkinase_Tyr; Protein tyrosine kinase
  6. NM_001354367.1NP_001341296.1  fibroblast growth factor receptor 1 isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623, AW206093
    Conserved Domains (4) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:462762
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  7. NM_001354368.2NP_001341297.1  fibroblast growth factor receptor 1 isoform 16 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623, AW206093
    Conserved Domains (3) summary
    cd05857
    Location:72156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:179268
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:371672
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  8. NM_001354369.1NP_001341298.1  fibroblast growth factor receptor 1 isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623, AW206093
    Conserved Domains (4) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:460760
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  9. NM_001354370.1NP_001341299.1  fibroblast growth factor receptor 1 isoform 18 precursor

    Status: REVIEWED

    Source sequence(s)
    AC087623, AW206093
    Conserved Domains (3) summary
    cd05857
    Location:72156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:179268
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:373673
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  10. NM_015850.4NP_056934.2  fibroblast growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_056934.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform A, III, and the 3-Ig domain form, lacks a 2-aa segment, compared to isoform 1. Both variants 2 and 12 encode the same isoform.
    Source sequence(s)
    AC087623, AK130555, AK222718, AW206093, BC018128, BQ774633, CX757985
    Consensus CDS
    CCDS43732.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000380280.5, ENST00000397091.9
    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:268357
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:260356
    IG_like; Immunoglobulin like
    pfam07679
    Location:158245
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:462763
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:476752
    Pkinase_Tyr; Protein tyrosine kinase
  11. NM_023105.3NP_075593.1  fibroblast growth factor receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_075593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform.
    Source sequence(s)
    AK130555, AW206093, BC018128, BQ774633, CX756209, CX757985, M34185
    Consensus CDS
    CCDS43730.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000348537.5, ENST00000356207.9
    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375676
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
  12. NM_023106.3NP_075594.1  fibroblast growth factor receptor 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_075594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses a different in-frame splice junction compared to variant 1. This variant encodes isoform 4, also known as isoform I, H3, and the 2-Ig Domain form, which is 91 aa shorter than isoform 1.
    Source sequence(s)
    AC087623, AK130555, AW206093, BC091494, BQ774633, CX757985, M37722
    Consensus CDS
    CCDS43731.1
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000327229.6, ENST00000326324.10
    Conserved Domains (6) summary
    cd04974
    Location:179268
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:72156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:171267
    IG_like; Immunoglobulin like
    pfam07679
    Location:69156
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:373674
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:387663
    Pkinase_Tyr; Protein tyrosine kinase
  13. NM_023110.3NP_075598.2  fibroblast growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_075598.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1, also known as isoform Alpha A1, IV and the 3-Ig domain+2 AA insert form.
    Source sequence(s)
    AC087623, AK130555, AW206093, BC018128, BQ774633, CX757985, X66945
    Consensus CDS
    CCDS6107.2
    UniProtKB/Swiss-Prot
    P11362
    Related
    ENSP00000400162.2, ENST00000447712.6
    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:464765
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    38411138..38468834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716310.3XP_006716373.1  fibroblast growth factor receptor 1 isoform X18

    See identical proteins and their annotated locations for XP_006716373.1

    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_006716303.3XP_006716366.1  fibroblast growth factor receptor 1 isoform X8

    See identical proteins and their annotated locations for XP_006716366.1

    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:464764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase
  3. XM_017013222.2XP_016868711.1  fibroblast growth factor receptor 1 isoform X10

  4. XM_017013221.1XP_016868710.1  fibroblast growth factor receptor 1 isoform X8

    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:464764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase
  5. XM_006716307.1XP_006716370.1  fibroblast growth factor receptor 1 isoform X9

    See identical proteins and their annotated locations for XP_006716370.1

    Conserved Domains (4) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:462762
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  6. XM_006716304.1XP_006716367.1  fibroblast growth factor receptor 1 isoform X8

    See identical proteins and their annotated locations for XP_006716367.1

    Conserved Domains (7) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:270359
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:163247
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:262358
    IG_like; Immunoglobulin like
    pfam07679
    Location:160247
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:464764
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:478754
    Pkinase_Tyr; Protein tyrosine kinase
  7. XM_006716314.2XP_006716377.1  fibroblast growth factor receptor 1 isoform X19

    See identical proteins and their annotated locations for XP_006716377.1

    Conserved Domains (3) summary
    cd05857
    Location:72156
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:179268
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:373673
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  8. XM_006716311.1XP_006716374.1  fibroblast growth factor receptor 1 isoform X18

    See identical proteins and their annotated locations for XP_006716374.1

    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
  9. XM_011544445.2XP_011542747.1  fibroblast growth factor receptor 1 isoform X3

    Conserved Domains (7) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:295391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193280
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:495795
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:509785
    Pkinase_Tyr; Protein tyrosine kinase
  10. XM_017013219.1XP_016868708.1  fibroblast growth factor receptor 1 isoform X4

  11. XM_011544443.2XP_011542745.1  fibroblast growth factor receptor 1 isoform X1

    Conserved Domains (7) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:295391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193280
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:497797
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:511787
    Pkinase_Tyr; Protein tyrosine kinase
  12. XM_011544444.1XP_011542746.1  fibroblast growth factor receptor 1 isoform X2

    Conserved Domains (7) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301390
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:293389
    IG_like; Immunoglobulin like
    pfam07679
    Location:191278
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:495795
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:509785
    Pkinase_Tyr; Protein tyrosine kinase
  13. XM_011544449.1XP_011542751.1  fibroblast growth factor receptor 1 isoform X14

    Conserved Domains (6) summary
    cd04974
    Location:212301
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:105189
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:204300
    IG_like; Immunoglobulin like
    pfam07679
    Location:102189
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:406706
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:420696
    Pkinase_Tyr; Protein tyrosine kinase
  14. XM_011544448.1XP_011542750.1  fibroblast growth factor receptor 1 isoform X13

    Conserved Domains (6) summary
    cd04974
    Location:214303
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:107191
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:206302
    IG_like; Immunoglobulin like
    pfam07679
    Location:104191
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:408708
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:422698
    Pkinase_Tyr; Protein tyrosine kinase
  15. XM_006716312.2XP_006716375.1  fibroblast growth factor receptor 1 isoform X18

    See identical proteins and their annotated locations for XP_006716375.1

    Conserved Domains (6) summary
    cd04974
    Location:181270
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:74158
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:173269
    IG_like; Immunoglobulin like
    pfam07679
    Location:71158
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:375675
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:389665
    Pkinase_Tyr; Protein tyrosine kinase
  16. XM_011544451.1XP_011542753.1  fibroblast growth factor receptor 1 isoform X20

    Conserved Domains (6) summary
    cd04974
    Location:173262
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:66150
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:165261
    IG_like; Immunoglobulin like
    pfam07679
    Location:63150
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:367667
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:381657
    Pkinase_Tyr; Protein tyrosine kinase
  17. XM_024447097.1XP_024302865.1  fibroblast growth factor receptor 1 isoform X11

    Conserved Domains (4) summary
    cd04973
    Location:32110
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:155239
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:262351
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:456756
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  18. XM_017013229.2XP_016868718.1  fibroblast growth factor receptor 1 isoform X21

  19. XM_017013224.2XP_016868713.1  fibroblast growth factor receptor 1 isoform X12

    Conserved Domains (4) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:460761
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  20. XM_017013220.1XP_016868709.1  fibroblast growth factor receptor 1 isoform X7

  21. XM_011544447.2XP_011542749.1  fibroblast growth factor receptor 1 isoform X6

    Conserved Domains (7) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:295391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193280
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:495796
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:509785
    Pkinase_Tyr; Protein tyrosine kinase
  22. XM_011544446.2XP_011542748.1  fibroblast growth factor receptor 1 isoform X5

    Conserved Domains (7) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:303392
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:196280
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:295391
    IG_like; Immunoglobulin like
    pfam07679
    Location:193280
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:497798
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:511787
    Pkinase_Tyr; Protein tyrosine kinase
  23. XM_017013227.1XP_016868716.1  fibroblast growth factor receptor 1 isoform X17

  24. XM_011544450.2XP_011542752.1  fibroblast growth factor receptor 1 isoform X15

    Conserved Domains (6) summary
    cd04974
    Location:212301
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:105189
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:204300
    IG_like; Immunoglobulin like
    pfam07679
    Location:102189
    I-set; Immunoglobulin I-set domain
    cd05098
    Location:406707
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
    pfam07714
    Location:420696
    Pkinase_Tyr; Protein tyrosine kinase
  25. XM_017013226.1XP_016868715.1  fibroblast growth factor receptor 1 isoform X16

  26. XM_017013225.2XP_016868714.1  fibroblast growth factor receptor 1 isoform X12

    Related
    ENSP00000497266.1, ENST00000649678.1
    Conserved Domains (4) summary
    cd04973
    Location:40118
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:161245
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:268357
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05098
    Location:460761
    PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
  27. XM_017013230.1XP_016868719.1  fibroblast growth factor receptor 1 isoform X22

  28. XM_017013231.1XP_016868720.1  fibroblast growth factor receptor 1 isoform X23

  29. XM_011544452.2XP_011542754.1  fibroblast growth factor receptor 1 isoform X24

    Conserved Domains (5) summary
    cd04973
    Location:73151
    Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd04974
    Location:301387
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:194278
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:293387
    IG_like; Immunoglobulin like
    pfam07679
    Location:191278
    I-set; Immunoglobulin I-set domain

RNA

  1. XR_001745496.1 RNA Sequence

  2. XR_001745495.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_023107.2: Suppressed sequence

    Description
    NM_023107.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_023108.2: Suppressed sequence

    Description
    NM_023108.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_023109.1: Suppressed sequence

    Description
    NM_023109.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  4. NM_023111.2: Suppressed sequence

    Description
    NM_023111.2: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.
  5. NM_032191.1: Suppressed sequence

    Description
    NM_032191.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
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