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ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 7903, updated on 1-Aug-2020

Summary

Official Symbol
ST8SIA4provided by HGNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:10871
See related
Ensembl:ENSG00000113532 MIM:602547
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PST; PST1; SIAT8D; ST8SIA-IV
Summary
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 6.6), lymph node (RPKM 4.8) and 19 other tissues See more
Orthologs

Genomic context

See ST8SIA4 in Genome Data Viewer
Location:
5q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (100806933..100903282, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (100142639..100238989, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 174 member A Neighboring gene RN7SK pseudogene 62 Neighboring gene microRNA 548p Neighboring gene uncharacterized LOC107986437 Neighboring gene uncharacterized LOC107986438 Neighboring gene general transcription factor IIIA pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that ST8SIA4 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with ST8SIA4 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34450, MGC61459

Gene Ontology Provided by GOA

Process Evidence Code Pubs
N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-glycan processing IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
ganglioside biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
Names
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase
SIAT8-D
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4
ST8SiaIV
alpha-2,8-sialyltransferase 8D
polysialyltransferase-1
sialyltransferase 8 (alpha-2, 8-polysialytransferase) D
sialyltransferase 8D
sialyltransferase St8Sia IV
sialytransferase St8Sia IV
NP_005659.1
NP_778222.1
XP_005272135.1
XP_011541932.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005668.6NP_005659.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor

    See identical proteins and their annotated locations for NP_005659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA836260, AC117530, AK292872, DA862968
    Consensus CDS
    CCDS4091.1
    UniProtKB/Swiss-Prot
    Q92187
    Related
    ENSP00000231461.4, ENST00000231461.10
    Conserved Domains (1) summary
    pfam00777
    Location:94353
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_175052.3NP_778222.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform b precursor

    See identical proteins and their annotated locations for NP_778222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in a shorter 3' coding region and a novel 3' UTR compared to variant 1. It encodes isoform b which is truncated at the C-terminus, compared to isoform a.
    Source sequence(s)
    BC027866, DA862968
    Consensus CDS
    CCDS47252.1
    UniProtKB/Swiss-Prot
    Q92187
    Related
    ENSP00000428914.1, ENST00000451528.2
    Conserved Domains (1) summary
    pfam00777
    Location:94168
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    100806933..100903282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543630.2XP_011541932.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:94255
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_005272078.3XP_005272135.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:94262
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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