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ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 7903, updated on 10-Dec-2017
Official Symbol
ST8SIA4provided by HGNC
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:10871
See related
Ensembl:ENSG00000113532 MIM:602547; Vega:OTTHUMG00000128727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PST; PST1; SIAT8D; ST8SIA-IV
Summary
The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 6.6), lymph node (RPKM 4.8) and 19 other tissues See more
Orthologs
Location:
5q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (100806935..100903285, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (100142639..100238989, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 174 member A Neighboring gene RNA, 7SK small nuclear pseudogene 62 Neighboring gene microRNA 548p Neighboring gene uncharacterized LOC107986437 Neighboring gene uncharacterized LOC107986438 Neighboring gene general transcription factor IIIA pseudogene 4

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that ST8SIA4 gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with ST8SIA4 PubMed

Go to the HIV-1, Human Interaction Database

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, organism-specific biosystem (from REACTOME)
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, organism-specific biosystemN-linked glycosylation commences with the 14-step synthesis of a dolichol lipid-linked oligosaccharide (LLO) consisting of 14 sugars (2 core GlcNAcs, 9 mannoses and 3 terminal GlcNAcs). This pathway ...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
  • NCAM1 interactions, organism-specific biosystem (from REACTOME)
    NCAM1 interactions, organism-specific biosystemThe neural cell adhesion molecule, NCAM1 is generally considered as a cell adhesion mediator, but it is also considered to be a signal transducing receptor molecule. NCAM1 is involved in multiple cis...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Sialic acid metabolism, organism-specific biosystem (from REACTOME)
    Sialic acid metabolism, organism-specific biosystemSialic acids are a family of 9 carbon alpha-keto acids that are usually present in the non reducing terminal of glycoconjuates on the cell surface of eukaryotic cells. These sialylated conjugates pla...
  • Synthesis of substrates in N-glycan biosythesis, organism-specific biosystem (from REACTOME)
    Synthesis of substrates in N-glycan biosythesis, organism-specific biosystemReactions for the synthesis of the small nucleotide-linked sugar substrates that are used in the synthesis of the N-glycan precursor and in the later steps of glycosylation are annotated here.All the...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC34450, MGC61459

Gene Ontology Provided by GOA

Process Evidence Code Pubs
N-glycan processing IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
ganglioside biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
oligosaccharide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
Names
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase
SIAT8-D
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4
ST8SiaIV
alpha-2,8-sialyltransferase 8D
polysialyltransferase-1
sialyltransferase 8 (alpha-2, 8-polysialytransferase) D
sialyltransferase 8D
sialyltransferase St8Sia IV
sialytransferase St8Sia IV
NP_005659.1
NP_778222.1
XP_005272135.1
XP_011541932.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005668.5NP_005659.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor

    See identical proteins and their annotated locations for NP_005659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA836260, AC117530, AK292872, DA862968
    Consensus CDS
    CCDS4091.1
    UniProtKB/Swiss-Prot
    Q92187
    Related
    ENSP00000231461.4, OTTHUMP00000158915, ENST00000231461.9, OTTHUMT00000250632
    Conserved Domains (1) summary
    pfam00777
    Location:94353
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_175052.2NP_778222.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform b precursor

    See identical proteins and their annotated locations for NP_778222.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons and its transcription extends past a splice site that is used in variant 1, resulting in a shorter 3' coding region and a novel 3' UTR compared to variant 1. It encodes isoform b which is truncated at the C-terminus, compared to isoform a.
    Source sequence(s)
    BC027866, DA862968
    Consensus CDS
    CCDS47252.1
    UniProtKB/Swiss-Prot
    Q92187
    Related
    ENSP00000428914.1, OTTHUMP00000227000, ENST00000451528.2, OTTHUMT00000370620
    Conserved Domains (1) summary
    pfam00777
    Location:94168
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

    Range
    100806935..100903285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543630.1XP_011541932.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:94255
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_005272078.2XP_005272135.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:94262
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    99575254..99671608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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