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St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 20452, updated on 18-Apr-2024

Summary

Official Symbol
St8sia4provided by MGI
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4provided by MGI
Primary source
MGI:MGI:106018
See related
Ensembl:ENSMUSG00000040710 AllianceGenome:MGI:106018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PST; PST-1; Siat8d; SIAT8-D; ST8SiaIV
Summary
Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process; glycoprotein metabolic process; and oligosaccharide metabolic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and lung. Orthologous to human ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 5.6), whole brain E14.5 (RPKM 4.9) and 19 other tissues See more
Orthologs
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Genomic context

Location:
1 D; 1 47.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (95515407..95595473, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (95587682..95667717, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01757 Neighboring gene predicted pseudogene 15427 Neighboring gene U7 small nuclear RNA, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E987 Neighboring gene STARR-positive B cell enhancer ABC_E11079 Neighboring gene STARR-positive B cell enhancer ABC_E10023 Neighboring gene STARR-positive B cell enhancer mm9_chr1:97507476-97507777 Neighboring gene STARR-positive B cell enhancer mm9_chr1:97515913-97516213 Neighboring gene STARR-positive B cell enhancer ABC_E11080 Neighboring gene STARR-positive B cell enhancer ABC_E1225 Neighboring gene STARR-positive B cell enhancer ABC_E10024 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:97562784-97562967 Neighboring gene STARR-positive B cell enhancer ABC_E7736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:97564187-97564374 Neighboring gene predicted gene, 30431 Neighboring gene STARR-positive B cell enhancer mm9_chr1:97589059-97589359 Neighboring gene RIKEN cDNA 4930598F16 gene Neighboring gene STARR-seq mESC enhancer starr_01758 Neighboring gene STARR-seq mESC enhancer starr_01759 Neighboring gene STARR-seq mESC enhancer starr_01760 Neighboring gene STARR-positive B cell enhancer ABC_E5786 Neighboring gene predicted gene, 22360

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
 
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in sialylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
Names
alpha-2,8-sialyltransferase 8D
polysialyltransferase-1
sialyltransferase 8 (alpha-2, 8-sialyltransferase) D
sialyltransferase 8D
sialyltransferase St8Sia IV
sialytransferase St8Sia IV
NP_001153217.1
NP_001407932.1
NP_001407933.1
NP_001407934.1
NP_033209.1
XP_036018814.1
XP_036018816.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159745.2NP_001153217.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893
    Consensus CDS
    CCDS78661.1
    UniProtKB/TrEMBL
    A0A087WRA0
    Related
    ENSMUSP00000140534.2, ENSMUST00000189556.2
    Conserved Domains (1) summary
    pfam00777
    Location:94262
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001421003.1NP_001407932.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893
  3. NM_001421004.1NP_001407933.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893
  4. NM_001421005.1NP_001407934.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893
  5. NM_009183.3NP_033209.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 1 precursor

    See identical proteins and their annotated locations for NP_033209.1

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893
    Consensus CDS
    CCDS15201.1
    UniProtKB/Swiss-Prot
    Q64692
    UniProtKB/TrEMBL
    Q53WR7, Q6PAS1, Q8BY70
    Related
    ENSMUSP00000043477.5, ENSMUST00000043336.11
    Conserved Domains (1) summary
    pfam00777
    Location:94353
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_185227.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    95515407..95595473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162921.1XP_036018814.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:189357
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_036162923.1XP_036018816.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:189357
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)