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ZNF655 zinc finger protein 655 [ Homo sapiens (human) ]

Gene ID: 79027, updated on 7-Jun-2020

Summary

Official Symbol
ZNF655provided by HGNC
Official Full Name
zinc finger protein 655provided by HGNC
Primary source
HGNC:HGNC:30899
See related
Ensembl:ENSG00000197343 MIM:617891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VIK; VIK-1
Summary
This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 10.9), lymph node (RPKM 10.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF655 in Genome Data Viewer
Location:
7q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (99558422..99576453)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99156034..99174076)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 3 pseudogene Neighboring gene uncharacterized LOC105375422 Neighboring gene family with sequence similarity 200 member A Neighboring gene transmembrane protein 225B Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ADP ribosylation factor 6 pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 5 Neighboring gene CYP3A5 promoter

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC5521, FLJ23461, MGC10859, MGC16203, DKFZp686M1631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 655
Names
vav-1 interacting Kruppel-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029962.1 RefSeqGene

    Range
    5001..23032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009958.1NP_001009958.1  zinc finger protein 655 isoform c

    See identical proteins and their annotated locations for NP_001009958.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has a distinct 5' UTR and an alternate 3' exon, compared to variant 7. Both variants 4 and 9 encode the same isoform (c), which has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    AK027114, BC063478, BE293580
    Consensus CDS
    CCDS34695.1
    UniProtKB/Swiss-Prot
    Q8N720
    Related
    ENSP00000396396.1, ENST00000440391.5
  2. NM_001009960.1NP_001009960.1  zinc finger protein 655 isoform a

    See identical proteins and their annotated locations for NP_001009960.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a distinct 5' UTR and lacks an alternate in-frame exon, compared to variant 7. Both variants 1 and 3 encode the same isoform (a), which is shorter than isoform f.
    Source sequence(s)
    AY099353, BC024770, BC037407, BE293580, CR749270
    Consensus CDS
    CCDS5669.1
    UniProtKB/Swiss-Prot
    Q8N720
    UniProtKB/TrEMBL
    Q68DU4
    Related
    ENSP00000377718.2, ENST00000394163.2
    Conserved Domains (3) summary
    COG5048
    Location:185290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:394419
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001083956.1NP_001077425.1  zinc finger protein 655 isoform f

    See identical proteins and their annotated locations for NP_001077425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents the longest transcript. Variants 7 and 8 encode the longest isoform (f).
    Source sequence(s)
    AK128057, BC024770, BC063478, CR749270, DN993232
    Consensus CDS
    CCDS47655.1
    UniProtKB/Swiss-Prot
    Q8N720
    UniProtKB/TrEMBL
    Q68DU4
    Related
    ENSP00000419135.1, ENST00000493277.5
    Conserved Domains (3) summary
    COG5048
    Location:220325
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:429454
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001085366.1NP_001078835.1  zinc finger protein 655 isoform c

    See identical proteins and their annotated locations for NP_001078835.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has an alternate 3' coding exon, compared to variant 7. Both variants 4 and 9 encode the same isoform (c), which has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    BC000823, BC063478, BM829333
    Consensus CDS
    CCDS34695.1
    UniProtKB/Swiss-Prot
    Q8N720
    Related
    ENSP00000350530.2, ENST00000357864.6
  5. NM_001085367.1NP_001078836.1  zinc finger protein 655 isoform b

    See identical proteins and their annotated locations for NP_001078836.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has a distinct 5' UTR and includes alternate exons in the 3' coding region and 3' UTR, compared to variant 7. Both variants 2 and 10 encode the same isoform (b), which has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    BC000823, BE293580, BI912391
    Consensus CDS
    CCDS5670.1
    UniProtKB/Swiss-Prot
    Q8N720
    Conserved Domains (2) summary
    smart00349
    Location:77123
    KRAB; krueppel associated box
    pfam01352
    Location:77116
    KRAB; KRAB box
  6. NM_001085368.1NP_001078837.1  zinc finger protein 655 isoform f

    See identical proteins and their annotated locations for NP_001078837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 7. Variants 7 and 8 encode the longest isoform (f).
    Source sequence(s)
    AK128057, BC024770, BE293580, BI548533, CR749270
    Consensus CDS
    CCDS47655.1
    UniProtKB/Swiss-Prot
    Q8N720
    UniProtKB/TrEMBL
    Q68DU4
    Related
    ENSP00000393876.1, ENST00000424881.5
    Conserved Domains (3) summary
    COG5048
    Location:220325
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:429454
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001363332.1NP_001350261.1  zinc finger protein 655 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC005020, AK128057, BC024770, BI548533, CR749270, DC418016
    Consensus CDS
    CCDS47655.1
    Conserved Domains (3) summary
    COG5048
    Location:220325
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:429454
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001363333.1NP_001350262.1  zinc finger protein 655 isoform f

    Status: REVIEWED

    Source sequence(s)
    AK128057, BC024770, BI548533, CR749270, DA314253
    Consensus CDS
    CCDS47655.1
    Conserved Domains (3) summary
    COG5048
    Location:220325
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367387
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:429454
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001363334.1NP_001350263.1  zinc finger protein 655 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC005020, AK128057, BC024770, BI548533, CR749270, CV030898, DC418016
    Consensus CDS
    CCDS5669.1
    Conserved Domains (3) summary
    COG5048
    Location:185290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:394419
    zf-H2C2_2; Zinc-finger double domain
  10. NM_024061.3NP_076966.1  zinc finger protein 655 isoform b

    See identical proteins and their annotated locations for NP_076966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes alternate exons in the 3' coding region and 3' UTR, compared to variant 7. Both variants 2 and 10 encode the same isoform (b), which has a shorter and distinct C-terminus compared to isoform f.
    Source sequence(s)
    BC000823, BC063478
    Consensus CDS
    CCDS5670.1
    UniProtKB/Swiss-Prot
    Q8N720
    Related
    ENSP00000322363.5, ENST00000320583.9
    Conserved Domains (2) summary
    smart00349
    Location:77123
    KRAB; krueppel associated box
    pfam01352
    Location:77116
    KRAB; KRAB box
  11. NM_138494.3NP_612503.1  zinc finger protein 655 isoform a

    See identical proteins and their annotated locations for NP_612503.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 7. Both variants 1 and 3 encode the same isoform (a), which is shorter than isoform f.
    Source sequence(s)
    AK128057, BC024770, BC037407, BC063478, CR749270
    Consensus CDS
    CCDS5669.1
    UniProtKB/Swiss-Prot
    Q8N720
    UniProtKB/TrEMBL
    Q68DU4
    Related
    ENSP00000252713.4, ENST00000252713.9
    Conserved Domains (3) summary
    COG5048
    Location:185290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:394419
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    99558422..99576453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012611.2XP_016868100.1  zinc finger protein 655 isoform X3

  2. XM_017012607.2XP_016868096.1  zinc finger protein 655 isoform X2

    UniProtKB/Swiss-Prot
    Q8N720
    Conserved Domains (3) summary
    COG5048
    Location:185290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332352
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:394419
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001009956.1: Suppressed sequence

    Description
    NM_001009956.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001009957.1: Suppressed sequence

    Description
    NM_001009957.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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