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Sp2 Sp2 transcription factor [ Mus musculus (house mouse) ]

Gene ID: 78912, updated on 12-May-2024

Summary

Official Symbol
Sp2provided by MGI
Official Full Name
Sp2 transcription factorprovided by MGI
Primary source
MGI:MGI:1926162
See related
Ensembl:ENSMUSG00000018678 AllianceGenome:MGI:1926162
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0048; 4930480I16Rik
Summary
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thymus adult (RPKM 15.0), spleen adult (RPKM 11.1) and 28 other tissues See more
Orthologs
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Genomic context

See Sp2 in Genome Data Viewer
Location:
11 D; 11 60.17 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96844158..96873785, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96953332..96982959, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11525 Neighboring gene STARR-seq mESC enhancer starr_30572 Neighboring gene proline rich 15-like Neighboring gene RIKEN cDNA D030028A08 gene Neighboring gene STARR-positive B cell enhancer ABC_E2367 Neighboring gene pyridoxine 5'-phosphate oxidase Neighboring gene STARR-positive B cell enhancer ABC_E11488 Neighboring gene STARR-positive B cell enhancer ABC_E20 Neighboring gene STARR-seq mESC enhancer starr_30576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916 Neighboring gene STARR-positive B cell enhancer ABC_E1429 Neighboring gene STARR-seq mESC enhancer starr_30578 Neighboring gene trans-acting transcription factor 6 Neighboring gene predicted gene 11532

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080964.2NP_001074433.1  transcription factor Sp2 isoform 2

    See identical proteins and their annotated locations for NP_001074433.1

    Status: VALIDATED

    Source sequence(s)
    AA267604, AL596384, BC086457, BP765918
    UniProtKB/Swiss-Prot
    Q6A0E1, Q9D2H6
    UniProtKB/TrEMBL
    D1MAF3
    Conserved Domains (3) summary
    sd00017
    Location:529548
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:570593
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001363225.1NP_001350154.1  transcription factor Sp2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK019649, AL596384
    Consensus CDS
    CCDS88237.1
    UniProtKB/TrEMBL
    D1MAF3, Q3UTN3, Q8BNQ4
    Related
    ENSMUSP00000051403.7, ENSMUST00000062652.7
    Conserved Domains (4) summary
    COG5048
    Location:443581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579601
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565588
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001363226.1NP_001350155.1  transcription factor Sp2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK080877, AL596384
    Consensus CDS
    CCDS88237.1
    UniProtKB/TrEMBL
    D1MAF3, Q3UTN3, Q8BNQ4
    Related
    ENSMUSP00000103249.2, ENSMUST00000107623.8
    Conserved Domains (4) summary
    COG5048
    Location:443581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579601
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565588
    zf-H2C2_2; Zinc-finger double domain
  4. NM_030220.4NP_084496.2  transcription factor Sp2 isoform 1

    See identical proteins and their annotated locations for NP_084496.2

    Status: VALIDATED

    Source sequence(s)
    AA267604, AK078246, AL596384, BB848633, BC086457, BP765918
    Consensus CDS
    CCDS36291.1
    UniProtKB/TrEMBL
    Q3UTN3, Q8C5J0
    Related
    ENSMUSP00000103250.3, ENSMUST00000107624.8
    Conserved Domains (3) summary
    sd00017
    Location:530549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:585607
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:571594
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96844158..96873785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534518.5XP_006534581.1  transcription factor Sp2 isoform X1

    See identical proteins and their annotated locations for XP_006534581.1

    UniProtKB/TrEMBL
    D1MAF3, Q3UTN3, Q8BNQ4
    Conserved Domains (4) summary
    COG5048
    Location:443581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579601
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565588
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006534519.4XP_006534582.1  transcription factor Sp2 isoform X1

    See identical proteins and their annotated locations for XP_006534582.1

    UniProtKB/TrEMBL
    D1MAF3, Q3UTN3, Q8BNQ4
    Conserved Domains (4) summary
    COG5048
    Location:443581
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:579601
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:565588
    zf-H2C2_2; Zinc-finger double domain