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SP2 Sp2 transcription factor [ Homo sapiens (human) ]

Gene ID: 6668, updated on 5-Aug-2022

Summary

Official Symbol
SP2provided by HGNC
Official Full Name
Sp2 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:11207
See related
Ensembl:ENSG00000167182 MIM:601801; AllianceGenome:HGNC:11207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 4.3), spleen (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See SP2 in Genome Data Viewer
Location:
17q21.32
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (47896236..47931731)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (48758026..48790753)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (45973602..46006323)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr17.3283 Neighboring gene SP2 divergent transcript Neighboring gene SP2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 5948 Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene proline rich 15 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates Sp2 transcription factor in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003110.6NP_003101.3  transcription factor Sp2

    See identical proteins and their annotated locations for NP_003101.3

    Status: REVIEWED

    Source sequence(s)
    BC016680, BC033814, DB451570, M97190
    Consensus CDS
    CCDS11521.2
    UniProtKB/Swiss-Prot
    A6NK74, Q02086
    Related
    ENSP00000365931.4, ENST00000376741.5
    Conserved Domains (4) summary
    COG5048
    Location:449587
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:530549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:585607
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:571594
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    47896236..47931731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525139.3XP_011523441.2  transcription factor Sp2 isoform X6

  2. XM_047436575.1XP_047292531.1  transcription factor Sp2 isoform X7

  3. XM_047436573.1XP_047292529.1  transcription factor Sp2 isoform X6

  4. XM_047436571.1XP_047292527.1  transcription factor Sp2 isoform X6

  5. XM_047436570.1XP_047292526.1  transcription factor Sp2 isoform X6

  6. XM_047436572.1XP_047292528.1  transcription factor Sp2 isoform X6

  7. XM_017024968.2XP_016880457.1  transcription factor Sp2 isoform X6

    Conserved Domains (4) summary
    COG5048
    Location:442580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:578600
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564587
    zf-H2C2_2; Zinc-finger double domain
  8. XM_006722025.3XP_006722088.1  transcription factor Sp2 isoform X6

    See identical proteins and their annotated locations for XP_006722088.1

    Conserved Domains (4) summary
    COG5048
    Location:442580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:578600
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564587
    zf-H2C2_2; Zinc-finger double domain
  9. XM_006722027.3XP_006722090.1  transcription factor Sp2 isoform X6

    See identical proteins and their annotated locations for XP_006722090.1

    Conserved Domains (4) summary
    COG5048
    Location:442580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:578600
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564587
    zf-H2C2_2; Zinc-finger double domain
  10. XM_011525143.2XP_011523445.1  transcription factor Sp2 isoform X6

    See identical proteins and their annotated locations for XP_011523445.1

    Conserved Domains (4) summary
    COG5048
    Location:442580
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:578600
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:564587
    zf-H2C2_2; Zinc-finger double domain
  11. XM_006722023.3XP_006722086.1  transcription factor Sp2 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:449587
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:530549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:585607
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:571594
    zf-H2C2_2; Zinc-finger double domain
  12. XM_047436569.1XP_047292525.1  transcription factor Sp2 isoform X5

  13. XM_047436576.1XP_047292532.1  transcription factor Sp2 isoform X8

  14. XM_047436577.1XP_047292533.1  transcription factor Sp2 isoform X10

  15. XM_011525136.3XP_011523438.1  transcription factor Sp2 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:553718
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:634653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:689711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:675698
    zf-H2C2_2; Zinc-finger double domain
  16. XM_011525137.3XP_011523439.1  transcription factor Sp2 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:553718
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:634653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:689711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:675698
    zf-H2C2_2; Zinc-finger double domain
  17. XM_011525138.3XP_011523440.1  transcription factor Sp2 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:553718
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:634653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:689711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:675698
    zf-H2C2_2; Zinc-finger double domain
  18. XM_011525140.3XP_011523442.1  transcription factor Sp2 isoform X9

    Conserved Domains (4) summary
    COG5048
    Location:553691
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:634653
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:689711
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:675698
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    48758026..48790753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)