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ZNF229 zinc finger protein 229 [ Homo sapiens (human) ]

Gene ID: 7772, updated on 11-Jun-2021

Summary

Official Symbol
ZNF229provided by HGNC
Official Full Name
zinc finger protein 229provided by HGNC
Primary source
HGNC:HGNC:13022
See related
Ensembl:ENSG00000278318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in ovary (RPKM 2.9), thyroid (RPKM 2.7) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF229 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44426251..44448578, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44930426..44952766, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 112 Neighboring gene zinc finger protein 285 Neighboring gene zinc finger protein 285B, pseudogene Neighboring gene zinc finger protein 180 Neighboring gene Sharpr-MPRA regulatory region 2061

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278510.3NP_001265439.2  zinc finger protein 229 isoform 2

    See identical proteins and their annotated locations for NP_001265439.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC245748, BM663713, CR936724
    Consensus CDS
    CCDS62706.1
    UniProtKB/TrEMBL
    A0A087WVZ7
    Related
    ENSP00000479807.1, ENST00000613197.4
    Conserved Domains (5) summary
    smart00349
    Location:3476
    KRAB; krueppel associated box
    COG5048
    Location:369781
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3473
    KRAB; KRAB box
    pfam13465
    Location:385410
    zf-H2C2_2; Zinc-finger double domain
  2. NM_014518.4NP_055333.3  zinc finger protein 229 isoform 1

    See identical proteins and their annotated locations for NP_055333.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC245748, AF192979, BM663713
    Consensus CDS
    CCDS42574.1
    UniProtKB/Swiss-Prot
    Q9UJW7
    Related
    ENSP00000479884.1, ENST00000614049.5
    Conserved Domains (5) summary
    smart00349
    Location:3474
    KRAB; krueppel associated box
    COG5048
    Location:375787
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:379399
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3473
    KRAB; KRAB box
    pfam13465
    Location:391416
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_103551.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB209357, AC245748, BM663713
    Related
    ENST00000620012.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    44426251..44448578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723372.4XP_006723435.1  zinc finger protein 229 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:646
    KRAB; krueppel associated box
    COG5048
    Location:347759
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:363388
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017027280.2XP_016882769.1  zinc finger protein 229 isoform X3

  3. XM_011527292.2XP_011525594.1  zinc finger protein 229 isoform X1

    See identical proteins and their annotated locations for XP_011525594.1

    UniProtKB/TrEMBL
    A0A087WVZ7
    Conserved Domains (5) summary
    smart00349
    Location:3476
    KRAB; krueppel associated box
    COG5048
    Location:369781
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3473
    KRAB; KRAB box
    pfam13465
    Location:385410
    zf-H2C2_2; Zinc-finger double domain
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