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Nat Genet. 2010 Sep;42(9):739-741. doi: 10.1038/ng.639. Epub 2010 Aug 8.

Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Author information

1
Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
2
Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
3
Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
4
Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana.
5
Department of Community Health, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
6
Health Research Unit, Ghana Health Service, Accra, Ghana.
7
MRC Laboratories, Fajara, Banjul, The Gambia.
8
Komfo Anokye Teaching Hospital, Kumasi, Ghana.
9
London School of Hygiene and Tropical Medicine, London, United Kingdom.
10
Karonga Prevention Study, Chilumba, Karonga District, Malawi.
#
Contributed equally

Erratum in

  • Nat Genet. 2011 Oct;43(10):1040.

Abstract

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

PMID:
20694014
PMCID:
PMC4975513
DOI:
10.1038/ng.639
[Indexed for MEDLINE]
Free PMC Article

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