Format

Send to:

Choose Destination

ZNF207 zinc finger protein 207 [ Homo sapiens (human) ]

Gene ID: 7756, updated on 3-Mar-2019

Summary

Official Symbol
ZNF207provided by HGNC
Official Full Name
zinc finger protein 207provided by HGNC
Primary source
HGNC:HGNC:12998
See related
Ensembl:ENSG00000010244 MIM:603428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BuGZ; hBuGZ
Expression
Ubiquitous expression in bone marrow (RPKM 30.2), lymph node (RPKM 22.5) and 25 other tissues See more
Orthologs

Genomic context

See ZNF207 in Genome Data Viewer
Location:
17q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (32350138..32381885)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (30677071..30697468)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371732 Neighboring gene rhomboid like 3 Neighboring gene chromosome 17 open reading frame 75 Neighboring gene oocyte secreted protein 1 pseudogene 2 Neighboring gene microRNA 632 Neighboring gene nudix hydrolase 15 pseudogene 2 Neighboring gene proteasome 26S subunit, non-ATPase 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761N202

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
microtubule bundle formation ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 
spindle matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle matrix IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
BUB3-interacting and GLEBS motif-containing protein ZNF207

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032293.2NP_001027464.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b

    See identical proteins and their annotated locations for NP_001027464.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 3. It encodes isoform b, which is shorter than isoform c.
    Source sequence(s)
    AI308956, BC002372
    Consensus CDS
    CCDS32614.1
    UniProtKB/Swiss-Prot
    O43670
    Related
    ENSP00000378168.2, ENST00000394673.6
    Conserved Domains (2) summary
    sd00017
    Location:1332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:405440
    SMN; Survival motor neuron protein (SMN)
  2. NM_001098507.1NP_001091977.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform c

    See identical proteins and their annotated locations for NP_001091977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AI308956, AK226172, BC002372
    Consensus CDS
    CCDS42294.1
    UniProtKB/Swiss-Prot
    O43670
    Related
    ENSP00000378165.4, ENST00000394670.8
    Conserved Domains (2) summary
    sd00017
    Location:1332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:436471
    SMN; Survival motor neuron protein (SMN)
  3. NM_003457.3NP_003448.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform a

    See identical proteins and their annotated locations for NP_003448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an in-frame exon in the coding region, compared to variant 3. It encodes isoform a, which is shorter than isoform c.
    Source sequence(s)
    AF046001, AI308956, BC002372
    Consensus CDS
    CCDS11271.1
    UniProtKB/Swiss-Prot
    O43670
    Related
    ENSP00000322777.6, ENST00000321233.10
    Conserved Domains (3) summary
    sd00017
    Location:1332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:420455
    SMN; Survival motor neuron protein (SMN)
    cl26464
    Location:224436
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    32350138..32381885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025019.2XP_016880508.1  BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X1

    UniProtKB/Swiss-Prot
    O43670
    Conserved Domains (2) summary
    sd00017
    Location:1332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam06003
    Location:436471
    SMN; Survival motor neuron protein (SMN)

RNA

  1. XR_001752616.2 RNA Sequence

  2. XR_002958061.1 RNA Sequence

  3. XR_001752615.2 RNA Sequence

  4. XR_002958059.1 RNA Sequence

  5. XR_001752613.2 RNA Sequence

  6. XR_934542.3 RNA Sequence

  7. XR_002958060.1 RNA Sequence

  8. XR_001752611.2 RNA Sequence

  9. XR_001752614.2 RNA Sequence

  10. XR_934543.3 RNA Sequence

    Related
    ENST00000581531.5
  11. XR_001752612.2 RNA Sequence

  12. XR_002958062.1 RNA Sequence

  13. XR_002958063.1 RNA Sequence

Support Center