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Zfp142 zinc finger protein 142 [ Mus musculus (house mouse) ]

Gene ID: 77264, updated on 7-Apr-2025

Summary

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Official Symbol
Zfp142provided by MGI
Official Full Name
zinc finger protein 142provided by MGI
Primary source
MGI:MGI:1924514
See related
Ensembl:ENSMUSG00000026135 AllianceGenome:MGI:1924514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf142; mKIAA0236; 9330177B18Rik
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system and inner ear. Orthologous to human ZNF142 (zinc finger protein 142). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in ovary adult (RPKM 10.5), thymus adult (RPKM 9.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp142 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74605490..74627308, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74566331..74588133, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 37 Neighboring gene STARR-positive B cell enhancer mm9_chr1:74552349-74552650 Neighboring gene CCR4-NOT transcription complex, subunit 9 Neighboring gene phospholipase C, delta 4 Neighboring gene STARR-seq mESC enhancer starr_01339 Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZNF142 mutation causes sex-dependent neurologic disorder. Proskorovski-Ohayon R, et al. J Med Genet, 2024 May 21. PMID 38296634
  2. Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice. Ehringer MA, et al. Alcohol Clin Exp Res, 2002 Nov. PMID 12436047
  3. Differential effects of ethanol on gamma-aminobutyric acid-A receptor-mediated synaptic currents in congenic strains of inbred long and short-sleep mice. Proctor WR, et al. Alcohol Clin Exp Res, 2004 Sep. PMID 15365296
  4. Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Ficker M, et al. Dev Biol, 2004 Apr 1. PMID 15031101
  5. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Ehringer MA, et al. Mamm Genome, 2001 Aug. PMID 11471062

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF142 mutation causes sex-dependent neurologic disorder.
    Title: ZNF142 mutation causes sex-dependent neurologic disorder.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 142

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310668.2 → NP_001297597.1  zinc finger protein 142 isoform 1

    See identical proteins and their annotated locations for NP_001297597.1

    Status: VALIDATED

    Source sequence(s)
    AC117610
    Consensus CDS
    CCDS78619.1
    UniProtKB/Swiss-Prot
    E9PY67, G5E869, Q3V1C1, Q8BWJ0, Q8BWL4, Q8CHH6
    UniProtKB/TrEMBL
    Q925J4
    Related
    ENSMUSP00000027315.8, ENSMUST00000027315.14
    Conserved Domains (4) summary
    COG5048
    Location:335 → 781
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:866 → 1015
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1694 → 1715
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1679 → 1703
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001432003.1 → NP_001418932.1  zinc finger protein 142 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117610
    UniProtKB/Swiss-Prot
    E9PY67, G5E869, Q3V1C1, Q8BWJ0, Q8BWL4, Q8CHH6
    UniProtKB/TrEMBL
    Q925J4

  3. NM_001432004.1 → NP_001418933.1  zinc finger protein 142 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117610
    UniProtKB/Swiss-Prot
    E9PY67, G5E869, Q3V1C1, Q8BWJ0, Q8BWL4, Q8CHH6
    UniProtKB/TrEMBL
    Q925J4

  4. NM_001432005.1 → NP_001418934.1  zinc finger protein 142 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117610
    UniProtKB/TrEMBL
    Q925J4

  5. NM_001432006.1 → NP_001418935.1  zinc finger protein 142 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117610
    UniProtKB/TrEMBL
    Q925J4

  6. NM_001432007.1 → NP_001418936.1  zinc finger protein 142 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC117610
    UniProtKB/TrEMBL
    Q925J4

  7. NM_001432008.1 → NP_001418937.1  zinc finger protein 142 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117610
    UniProtKB/TrEMBL
    Q925J4

  8. NM_001432009.1 → NP_001418938.1  zinc finger protein 142 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC117610
    UniProtKB/TrEMBL
    Q925J4

  9. NM_001432010.1 → NP_001418939.1  zinc finger protein 142 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC117610
    UniProtKB/TrEMBL
    Q925J4

  10. NM_029888.4 → NP_084164.1  zinc finger protein 142 isoform 2

    See identical proteins and their annotated locations for NP_084164.1

    Status: VALIDATED

    Source sequence(s)
    AC117610
    Consensus CDS
    CCDS35618.1
    UniProtKB/TrEMBL
    Q925J4
    Related
    ENSMUSP00000109366.2, ENSMUST00000113737.8
    Conserved Domains (4) summary
    COG5048
    Location:232 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:763 → 912
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1591 → 1612
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1576 → 1600
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74605490..74627308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496319.4 → XP_006496382.1  zinc finger protein 142 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:335 → 781
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:866 → 1015
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1694 → 1715
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1679 → 1703
    zf-H2C2_2; Zinc-finger double domain

  2. XM_036154349.1 → XP_036010242.1  zinc finger protein 142 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:144 → 590
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:675 → 824
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1503 → 1524
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1488 → 1512
    zf-H2C2_2; Zinc-finger double domain

  3. XM_036154354.1 → XP_036010247.1  zinc finger protein 142 isoform X5

    UniProtKB/TrEMBL
    Q925J4
    Conserved Domains (4) summary
    COG5048
    Location:22 → 443
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:528 → 677
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1356 → 1377
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1341 → 1365
    zf-H2C2_2; Zinc-finger double domain

  4. XM_030243549.1 → XP_030099409.1  zinc finger protein 142 isoform X4

    UniProtKB/TrEMBL
    Q925J4
    Related
    ENSMUSP00000065149.7, ENSMUST00000066986.13
    Conserved Domains (4) summary
    COG5048
    Location:134 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:665 → 814
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1493 → 1514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1478 → 1502
    zf-H2C2_2; Zinc-finger double domain

  5. XM_036154348.1 → XP_036010241.1  zinc finger protein 142 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:232 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:763 → 912
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1591 → 1612
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1576 → 1600
    zf-H2C2_2; Zinc-finger double domain

  6. XM_036154350.1 → XP_036010243.1  zinc finger protein 142 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:134 → 580
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:665 → 814
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1493 → 1514
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1478 → 1502
    zf-H2C2_2; Zinc-finger double domain

  7. XM_030243546.1 → XP_030099406.1  zinc finger protein 142 isoform X2

    UniProtKB/TrEMBL
    Q925J4
    Conserved Domains (4) summary
    COG5048
    Location:232 → 678
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:763 → 912
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1591 → 1612
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1576 → 1600
    zf-H2C2_2; Zinc-finger double domain

  8. XM_006496318.3 → XP_006496381.1  zinc finger protein 142 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:335 → 781
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10811
    Location:866 → 1015
    rne; ribonuclease E; Reviewed
    sd00017
    Location:1694 → 1715
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1679 → 1703
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E869.1 GenPept UniProtKB/Swiss-Prot:G5E869

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