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ZNF142 zinc finger protein 142 [ Homo sapiens (human) ]

Gene ID: 7701, updated on 27-Jun-2020

Summary

Official Symbol
ZNF142provided by HGNC
Official Full Name
zinc finger protein 142provided by HGNC
Primary source
HGNC:HGNC:12927
See related
Ensembl:ENSG00000115568 MIM:604083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA4654; pHZ-49; NEDISHM
Summary
The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Expression
Ubiquitous expression in brain (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF142 in Genome Data Viewer
Location:
2q35
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218633329..218659623, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219502639..219524355, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene RNA, U6 small nuclear 136, pseudogene Neighboring gene phospholipase C delta 4 Neighboring gene tRNA-Gln (anticodon CTG) 16-1 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
NEURODEVELOPMENTAL DISORDER WITH IMPAIRED SPEECH AND HYPERKINETIC MOVEMENTS
MedGen: C5193088 OMIM: 618425 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
NHGRI GWA Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 142
Names
zinc finger protein 142 (clone pHZ-49)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033099.1 RefSeqGene

    Range
    4918..28349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001105537.4NP_001099007.1  zinc finger protein 142 isoform 1

    See identical proteins and their annotated locations for NP_001099007.1

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
    Consensus CDS
    CCDS42817.1
    UniProtKB/Swiss-Prot
    P52746
    Related
    ENSP00000408643.1, ENST00000449707.5
    Conserved Domains (2) summary
    sd00017
    Location:15381559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:7281019
    Atrophin-1; Atrophin-1 family
  2. NM_001366287.2NP_001353216.1  zinc finger protein 142 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
    Conserved Domains (3) summary
    sd00017
    Location:13751396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:13601384
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:565856
    Atrophin-1; Atrophin-1 family
  3. NM_001366288.2NP_001353217.1  zinc finger protein 142 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
    Conserved Domains (3) summary
    sd00017
    Location:13751396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:13601384
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:565856
    Atrophin-1; Atrophin-1 family
  4. NM_001366289.2NP_001353218.1  zinc finger protein 142 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
    Conserved Domains (3) summary
    sd00017
    Location:13751396
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:13601384
    zf-H2C2_2; Zinc-finger double domain
    cl26464
    Location:565856
    Atrophin-1; Atrophin-1 family
  5. NM_001366290.3NP_001353219.1  zinc finger protein 142 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
    Conserved Domains (2) summary
    sd00017
    Location:17381759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:9281219
    Atrophin-1; Atrophin-1 family
  6. NM_001366291.2NP_001353220.1  zinc finger protein 142 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
    Conserved Domains (2) summary
    sd00017
    Location:15381559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:7281019
    Atrophin-1; Atrophin-1 family
  7. NM_001367339.1NP_001354268.1  zinc finger protein 142 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
  8. NM_001367340.1NP_001354269.1  zinc finger protein 142 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
  9. NM_001367341.1NP_001354270.1  zinc finger protein 142 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
  10. NM_001367342.1NP_001354271.1  zinc finger protein 142 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
  11. NM_001379659.1NP_001366588.1  zinc finger protein 142 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
  12. NM_001379660.1NP_001366589.1  zinc finger protein 142 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
  13. NM_001379661.1NP_001366590.1  zinc finger protein 142 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810
  14. NM_001379662.1NP_001366591.1  zinc finger protein 142 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC012510, AC079810

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218633329..218659623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511788.2XP_011510090.1  zinc finger protein 142 isoform X1

    See identical proteins and their annotated locations for XP_011510090.1

    Conserved Domains (2) summary
    sd00017
    Location:17381759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:9281219
    Atrophin-1; Atrophin-1 family
  2. XM_011511787.2XP_011510089.1  zinc finger protein 142 isoform X1

    See identical proteins and their annotated locations for XP_011510089.1

    Conserved Domains (2) summary
    sd00017
    Location:17381759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:9281219
    Atrophin-1; Atrophin-1 family
  3. XM_011511786.2XP_011510088.1  zinc finger protein 142 isoform X1

    See identical proteins and their annotated locations for XP_011510088.1

    Conserved Domains (2) summary
    sd00017
    Location:17381759
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:9281219
    Atrophin-1; Atrophin-1 family
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