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ZNF157 zinc finger protein 157 [ Homo sapiens (human) ]

Gene ID: 7712, updated on 23-Nov-2021

Summary

Official Symbol
ZNF157provided by HGNC
Official Full Name
zinc finger protein 157provided by HGNC
Primary source
HGNC:HGNC:12942
See related
Ensembl:ENSG00000147117 MIM:300024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF22
Summary
This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZNF157 in Genome Data Viewer
Location:
Xp11.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47370578..47414498)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47229977..47273897)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 785, pseudogene Neighboring gene Sharpr-MPRA regulatory region 8750 Neighboring gene UBX domain protein 4 pseudogene Neighboring gene small nucleolar RNA, H/ACA box 11C Neighboring gene nucleophosmin 1 pseudogene 49 Neighboring gene zinc finger protein 41 Neighboring gene long intergenic non-protein coding RNA 1560

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 157
Names
zinc finger protein 22
zinc finger protein HZF22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003446.4NP_003437.2  zinc finger protein 157

    See identical proteins and their annotated locations for NP_003437.2

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL591503
    Consensus CDS
    CCDS14278.1
    UniProtKB/Swiss-Prot
    P51786
    Related
    ENSP00000366273.4, ENST00000377073.4
    Conserved Domains (6) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:159499
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220240
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:470492
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:345367
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    47370578..47414498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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