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ZNF141 zinc finger protein 141 [ Homo sapiens (human) ]

Gene ID: 7700, updated on 11-Jun-2021

Summary

Official Symbol
ZNF141provided by HGNC
Official Full Name
zinc finger protein 141provided by HGNC
Primary source
HGNC:HGNC:12926
See related
Ensembl:ENSG00000131127 MIM:194648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D4S90; pHZ-44
Summary
The protein encoded by this gene is a zinc finger protein that may be a tumor suppressor. Defects in this gene have been associated with autosomal recessive postaxial polydactyly type A. [provided by RefSeq, Jan 2017]
Expression
Ubiquitous expression in adrenal (RPKM 3.7), lymph node (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF141 in Genome Data Viewer
Location:
4p16.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (337814..384868)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (331603..378657)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 732 Neighboring gene uncharacterized LOC105374336 Neighboring gene microRNA 571 Neighboring gene zinc finger protein 519 pseudogene 4 Neighboring gene HERV-FRD provirus ancestral Env polyprotein pseudogene Neighboring gene ATP binding cassette subfamily A member 11, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 141
Names
zinc finger protein 141 (clone pHZ-44)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052984.1 RefSeqGene

    Range
    5001..52087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348277.2NP_001335206.1  zinc finger protein 141 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC079140, AC092574
    UniProtKB/TrEMBL
    Q4W5N2
    Conserved Domains (3) summary
    COG5048
    Location:42338
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:315395
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:209229
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001348278.2NP_001335207.1  zinc finger protein 141 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079140, AC092574
    Consensus CDS
    CCDS87195.1
    UniProtKB/TrEMBL
    D6RIY0
    Related
    ENSP00000425799.1, ENST00000512994.5
    Conserved Domains (1) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
  3. NM_001348279.2NP_001335208.1  zinc finger protein 141 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079140
    Conserved Domains (1) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
  4. NM_001348280.2NP_001335209.1  zinc finger protein 141 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079140
    Conserved Domains (1) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
  5. NM_003441.4NP_003432.1  zinc finger protein 141 isoform 1

    See identical proteins and their annotated locations for NP_003432.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC079140, AC092574
    Consensus CDS
    CCDS33931.1
    UniProtKB/Swiss-Prot
    Q15928
    Related
    ENSP00000240499.7, ENST00000240499.8
    Conserved Domains (5) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:118414
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:297322
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    337814..384868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513562.3XP_011511864.1  zinc finger protein 141 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:64103
    KRAB; krueppel associated box
    COG5048
    Location:146442
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:313333
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:64103
    KRAB; KRAB box
    pfam13465
    Location:325350
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017008591.2XP_016864080.1  zinc finger protein 141 isoform X1

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