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Conserved domains on  [gi|767929374|ref|XP_011511864|]
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zinc finger protein 141 isoform X2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 63-103 3.48e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 3.48e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767929374   63 LLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 103
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-442 1.70e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 146 KSLNECKLQKGGYNEFNECLSTTQSK-ILQCKASVKVVSKFSNSNKRKTRHTGEKHFKEC--GKSFQKFSHLTQHKVIHA 222
Cdd:COG5048  143 ISNLRNNPLPGNNSSSVNTPQSNSLHpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENspLSSSYSIPSSSSDQNLEN 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 223 GEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSSHFAKHKIIHTGE-------KPYKCEECGKAFNRF 295
Cdd:COG5048  223 SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRS 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 296 TTLTKHKR--IHAGEKPITCEE----CRKIFTSSSNFAKHKRIHTGEKPYKCEEC-------GKAFNRSTTLTKHKRIHT 362
Cdd:COG5048  303 SPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLK 382

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 363 GEKPYTCE--ECGKAFRQSSKLNEHKKVHTGERP--YKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDR 438
Cdd:COG5048  383 NDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462


                 ....
gi 767929374 439 SQHK 442
Cdd:COG5048  463 NHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 419-499 3.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 419 GEKPYKCE--ECGKAFRRSTDRSQHKKI-HSADKPYKCKECDKafkqfsllsqHKKIHTVDKPYKCKDCDKAFKRFSHLN 495
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....
gi 767929374 496 KHKK 499
Cdd:COG5189  416 YHRK 419
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 63-103 3.48e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 3.48e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767929374   63 LLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 103
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
64-103 4.12e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 92.27  E-value: 4.12e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767929374    64 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 103
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL 40
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 64-103 5.86e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.60  E-value: 5.86e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767929374  64 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 103
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-442 1.70e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 146 KSLNECKLQKGGYNEFNECLSTTQSK-ILQCKASVKVVSKFSNSNKRKTRHTGEKHFKEC--GKSFQKFSHLTQHKVIHA 222
Cdd:COG5048  143 ISNLRNNPLPGNNSSSVNTPQSNSLHpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENspLSSSYSIPSSSSDQNLEN 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 223 GEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSSHFAKHKIIHTGE-------KPYKCEECGKAFNRF 295
Cdd:COG5048  223 SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRS 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 296 TTLTKHKR--IHAGEKPITCEE----CRKIFTSSSNFAKHKRIHTGEKPYKCEEC-------GKAFNRSTTLTKHKRIHT 362
Cdd:COG5048  303 SPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLK 382

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 363 GEKPYTCE--ECGKAFRQSSKLNEHKKVHTGERP--YKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDR 438
Cdd:COG5048  383 NDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462


                 ....
gi 767929374 439 SQHK 442
Cdd:COG5048  463 NHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 1.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 767929374  325 NFAKHKRIHTGEKPYKCEECGKAFNR 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 419-499 3.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 419 GEKPYKCE--ECGKAFRRSTDRSQHKKI-HSADKPYKCKECDKafkqfsllsqHKKIHTVDKPYKCKDCDKAFKRFSHLN 495
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....
gi 767929374 496 KHKK 499
Cdd:COG5189  416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
466-490 5.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.95e-04
                          10        20
                  ....*....|....*....|....*
gi 767929374  466 LSQHKKIHTVDKPYKCKDCDKAFKR 490
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 63-103 3.48e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.76  E-value: 3.48e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767929374   63 LLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 103
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
64-103 4.12e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 92.27  E-value: 4.12e-23
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767929374    64 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 103
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL 40
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 64-103 5.86e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.60  E-value: 5.86e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767929374  64 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 103
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-442 1.70e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 146 KSLNECKLQKGGYNEFNECLSTTQSK-ILQCKASVKVVSKFSNSNKRKTRHTGEKHFKEC--GKSFQKFSHLTQHKVIHA 222
Cdd:COG5048  143 ISNLRNNPLPGNNSSSVNTPQSNSLHpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENspLSSSYSIPSSSSDQNLEN 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 223 GEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSSHFAKHKIIHTGE-------KPYKCEECGKAFNRF 295
Cdd:COG5048  223 SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRS 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 296 TTLTKHKR--IHAGEKPITCEE----CRKIFTSSSNFAKHKRIHTGEKPYKCEEC-------GKAFNRSTTLTKHKRIHT 362
Cdd:COG5048  303 SPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLK 382

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 363 GEKPYTCE--ECGKAFRQSSKLNEHKKVHTGERP--YKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDR 438
Cdd:COG5048  383 NDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462


                 ....
gi 767929374 439 SQHK 442
Cdd:COG5048  463 NHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-502 7.92e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 7.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 322 SSSNFAKHKRIHTgekPYKCEECGKAFNRSTTLTKHKR--IHTGE--KPYTCEE--CGKAFRQSSKLNEHKKVHTGERPY 395
Cdd:COG5048  276 NESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 396 KCdecgkafgrsrVLNEHKKIHTGEKPYKceecgkafrrSTDRSQHKKIHSADKPYKC--KECDKAFKQFSLLSQHKKIH 473
Cdd:COG5048  353 KE-----------KLLNSSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767929374 474 TVDKP--YKCKDCDKAFKRFSHLNKHKKIHT 502
Cdd:COG5048  412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
253-502 6.27e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 253 KPFTCEECGSIFTTSSHFAKHKIIHTGEKPYKC--EECGKAFNRFTTLTKHKRIHAGEKPITCEECRKIFTSSSNFAKHK 330
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 331 RIHTGE-KPYKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKAFRQSSKLNE----------------------HKK 387
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanslskdpssnlslliSSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 388 VHTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDRSQHKKIHSADKPYKCKECDKAFKQFSLLS 467
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767929374 468 QHKKIHT-------VDKPYKCKDCDKAFKRFSHLNKHK--KIHT 502
Cdd:COG5048  272 SSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHS 315
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-388 6.66e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 6.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 202 KECGKSFQKFSHLTQHKVIHAGE-------KPYTCEECGKAFKWSLIFNEHKR--IHTGE--KPFTCEE--CGSIFTTSS 268
Cdd:COG5048  258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 269 HFAKHKIIHTGEKPYKC--EECGKAFN------RFTTLTKHKRIHAGEKPITCE-ECRKIFTSSSNFAKHKRIHTGEKP- 338
Cdd:COG5048  338 ALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPy 417

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767929374 339 -YKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKaFRQSSKLNEHKKV 388
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-502 2.73e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 203 ECGKSFQKFSHLTQHKVIHAGEKPYTC--EECGKAFKWSLIFNEHKRIHTGEKPFTCE-ECGSIFTTSSHFAKHKIIHTG 279
Cdd:COG5048   38 NCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNS 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 280 EKPYKCEECGKAFNRFTTLTK--HKRIHAGEKPitceeCRKIFTSSSNFAKHKRIHtGEKPYKCEECGKAFNRSTTLtkH 357
Cdd:COG5048  118 NDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNP-----LPGNNSSSVNTPQSNSLH-PPLPANSLSKDPSSNLSLLI--S 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 358 KRIHTGEKPYTCEECGKAFRQSSKLNEHKKVHTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFR--RS 435
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptAS 269

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767929374 436 TDRSQHKKIHSAD-----KPYKCKECDKAFKQFSLLSQHK--KIHT--VDKPYKC--KDCDKAFKRFSHLNKHKKIHT 502
Cdd:COG5048  270 SQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKLFSRNDALKRHILLHT 347
zf-H2C2_2 pfam13465
Zinc-finger double domain;
325-350 1.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 767929374  325 NFAKHKRIHTGEKPYKCEECGKAFNR 350
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 391-471 2.30e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 391 GERPYKCD--ECGKAFGRSRVLNEHKKiHTgekpykceECGKAFRRSTDRSQHKKIHSADKPYKCKECDKAFKQFSLLSQ 468
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 767929374 469 HKK 471
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
410-434 3.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.08e-04
                          10        20
                  ....*....|....*....|....*
gi 767929374  410 LNEHKKIHTGEKPYKCEECGKAFRR 434
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 279-358 3.32e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 279 GEKPYKCE--ECGKAFNRFTTLtKHKRIHAGEKPITCEECRKIftsssnfaKHKRIHTGEKPYKCEECGKAFNRSTTLTK 356
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 767929374 357 HK 358
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 419-499 3.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 419 GEKPYKCE--ECGKAFRRSTDRSQHKKI-HSADKPYKCKECDKafkqfsllsqHKKIHTVDKPYKCKDCDKAFKRFSHLN 495
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....
gi 767929374 496 KHKK 499
Cdd:COG5189  416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
466-490 5.95e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.95e-04
                          10        20
                  ....*....|....*....|....*
gi 767929374  466 LSQHKKIHTVDKPYKCKDCDKAFKR 490
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-378 6.69e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.69e-04
                          10        20
                  ....*....|....*....|....*
gi 767929374  354 LTKHKRIHTGEKPYTCEECGKAFRQ 378
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-294 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 767929374  269 HFAKHKIIHTGEKPYKCEECGKAFNR 294
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 223-302 1.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767929374 223 GEKPYTCE--ECGKAFKWSLIFNEHkRIHTGEKPFTCEECGSIfttsshfaKHKIIHTGEKPYKCEECGKAFNRFTTLTK 300
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 767929374 301 HK 302
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-404 1.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|...
gi 767929374  382 LNEHKKVHTGERPYKCDECGKAF 404
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-462 5.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.21e-03
                          10        20
                  ....*....|....*....|...
gi 767929374  440 QHKKIHSADKPYKCKECDKAFKQ 462
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 479-501 5.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.78e-03
                          10        20
                  ....*....|....*....|...
gi 767929374  479 YKCKDCDKAFKRFSHLNKHKKIH 501
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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