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ZNF76 zinc finger protein 76 [ Homo sapiens (human) ]

Gene ID: 7629, updated on 7-Jun-2020

Summary

Official Symbol
ZNF76provided by HGNC
Official Full Name
zinc finger protein 76provided by HGNC
Primary source
HGNC:HGNC:13149
See related
Ensembl:ENSG00000065029 MIM:194549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF523; Zfp523; D6S229E
Expression
Ubiquitous expression in thyroid (RPKM 13.0), testis (RPKM 11.1) and 25 other tissues See more
Orthologs

Genomic context

See ZNF76 in Genome Data Viewer
Location:
6p21.31
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (35259473..35295985)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35226691..35263762)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267955 Neighboring gene uncharacterized LOC101929285 Neighboring gene signal peptide, CUB domain and EGF like domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 9100 Neighboring gene DEF6 guanine nucleotide exchange factor Neighboring gene peroxisome proliferator activated receptor delta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 76
Names
zinc finger protein 523
zinc finger protein 76 (expressed in testis)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001292032.2NP_001278961.1  zinc finger protein 76 isoform 2

    See identical proteins and their annotated locations for NP_001278961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BE962441, DC299240, M91592, Z97832
    Consensus CDS
    CCDS75435.1
    UniProtKB/Swiss-Prot
    P36508
    UniProtKB/TrEMBL
    A0A024RCW5
    Related
    ENSP00000344097.5, ENST00000339411.5
    Conserved Domains (4) summary
    COG5048
    Location:192250
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:212238
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:225346
    zf-C2H2_aberr; Aberrant zinc-finger
  2. NM_003427.5NP_003418.2  zinc finger protein 76 isoform 1

    See identical proteins and their annotated locations for NP_003418.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC002549, BE962441, DC299240, Z97832
    Consensus CDS
    CCDS4801.1
    UniProtKB/Swiss-Prot
    P36508
    UniProtKB/TrEMBL
    A0A024RCU3
    Related
    ENSP00000363064.3, ENST00000373953.8
    Conserved Domains (4) summary
    COG5048
    Location:179366
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:106220
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:167189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28087
    Location:279483
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    35259473..35295985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011256.1XP_016866745.1  zinc finger protein 76 isoform X12

    UniProtKB/TrEMBL
    A0A024RCW5
    Conserved Domains (4) summary
    COG5048
    Location:192250
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:212238
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:225346
    zf-C2H2_aberr; Aberrant zinc-finger
  2. XM_011514847.3XP_011513149.1  zinc finger protein 76 isoform X1

    See identical proteins and their annotated locations for XP_011513149.1

    Conserved Domains (4) summary
    COG5048
    Location:204262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:179201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:224250
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:237358
    zf-C2H2_aberr; Aberrant zinc-finger
  3. XM_017011248.2XP_016866737.1  zinc finger protein 76 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:204262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:179201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:224250
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:237358
    zf-C2H2_aberr; Aberrant zinc-finger
  4. XM_017011251.2XP_016866740.1  zinc finger protein 76 isoform X6

    Conserved Domains (4) summary
    COG5048
    Location:204262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:179201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:224250
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:237358
    zf-C2H2_aberr; Aberrant zinc-finger
  5. XM_017011252.2XP_016866741.1  zinc finger protein 76 isoform X7

    Conserved Domains (4) summary
    COG5048
    Location:204262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:179201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:224250
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:237358
    zf-C2H2_aberr; Aberrant zinc-finger
  6. XM_017011250.2XP_016866739.1  zinc finger protein 76 isoform X5

    Conserved Domains (3) summary
    sd00017
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:224250
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:207328
    zf-C2H2_aberr; Aberrant zinc-finger
  7. XM_011514850.3XP_011513152.1  zinc finger protein 76 isoform X3

    See identical proteins and their annotated locations for XP_011513152.1

    Conserved Domains (4) summary
    COG5048
    Location:192250
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:212238
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:225346
    zf-C2H2_aberr; Aberrant zinc-finger
  8. XM_017011249.2XP_016866738.1  zinc finger protein 76 isoform X4

    UniProtKB/Swiss-Prot
    P36508
    UniProtKB/TrEMBL
    A0A024RCU3
    Conserved Domains (4) summary
    COG5048
    Location:179366
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:106220
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:167189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl28087
    Location:279483
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  9. XM_017011253.2XP_016866742.1  zinc finger protein 76 isoform X9

  10. XM_011514855.2XP_011513157.1  zinc finger protein 76 isoform X8

    See identical proteins and their annotated locations for XP_011513157.1

    Conserved Domains (4) summary
    COG5048
    Location:139197
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159185
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:172293
    zf-C2H2_aberr; Aberrant zinc-finger
  11. XM_017011255.1XP_016866744.1  zinc finger protein 76 isoform X11

  12. XM_017011257.1XP_016866746.1  zinc finger protein 76 isoform X13

  13. XM_011514854.2XP_011513156.1  zinc finger protein 76 isoform X8

    See identical proteins and their annotated locations for XP_011513156.1

    Conserved Domains (4) summary
    COG5048
    Location:139197
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159185
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:172293
    zf-C2H2_aberr; Aberrant zinc-finger
  14. XM_011514849.2XP_011513151.1  zinc finger protein 76 isoform X3

    See identical proteins and their annotated locations for XP_011513151.1

    Conserved Domains (4) summary
    COG5048
    Location:192250
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:167189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:212238
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:225346
    zf-C2H2_aberr; Aberrant zinc-finger
  15. XM_017011254.1XP_016866743.1  zinc finger protein 76 isoform X9

  16. XM_011514846.2XP_011513148.1  zinc finger protein 76 isoform X1

    See identical proteins and their annotated locations for XP_011513148.1

    Conserved Domains (4) summary
    COG5048
    Location:204262
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:179201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:224250
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:237358
    zf-C2H2_aberr; Aberrant zinc-finger
  17. XM_011514856.3XP_011513158.1  zinc finger protein 76 isoform X10

    Conserved Domains (4) summary
    COG5048
    Location:132190
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:107129
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152178
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:165286
    zf-C2H2_aberr; Aberrant zinc-finger

RNA

  1. XR_001743621.2 RNA Sequence

  2. XR_001743622.2 RNA Sequence

  3. XR_001743619.2 RNA Sequence

  4. XR_001743626.2 RNA Sequence

  5. XR_001743624.2 RNA Sequence

  6. XR_001743627.2 RNA Sequence

  7. XR_001743620.2 RNA Sequence

  8. XR_001743623.2 RNA Sequence

  9. XR_001743628.1 RNA Sequence

  10. XR_002956304.1 RNA Sequence

  11. XR_001743629.1 RNA Sequence

  12. XR_001743625.1 RNA Sequence

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