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MZF1 myeloid zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 7593, updated on 8-Dec-2018

Summary

Official Symbol
MZF1provided by HGNC
Official Full Name
myeloid zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:13108
See related
Ensembl:ENSG00000099326 MIM:194550
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6
Expression
Ubiquitous expression in spleen (RPKM 4.6), prostate (RPKM 4.2) and 25 other tissues See more
Orthologs

Genomic context

See MZF1 in Genome Data Viewer
Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (58561917..58574478, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59073284..59085757, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 2A Neighboring gene ubiquitin conjugating enzyme E2 M Neighboring gene MZF1 antisense RNA 1 Neighboring gene CENPB DNA-binding domains containing 1 pseudogene 1 Neighboring gene uncharacterized LOC107987272

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
myeloid zinc finger 1
Names
zinc finger and SCAN domain-containing protein 6
zinc finger protein 42 (myeloid-specific retinoic acid-responsive)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267033.1NP_001253962.1  myeloid zinc finger 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF055078, BC007777, BC053316, BQ446552, BU620994
    Consensus CDS
    CCDS59427.1
    UniProtKB/Swiss-Prot
    P28698
    Related
    ENSP00000469378.1, ENST00000594234.5
    Conserved Domains (2) summary
    smart00431
    Location:40152
    SCAN; leucine rich region
    pfam02023
    Location:40128
    SCAN; SCAN domain
  2. NM_003422.2NP_003413.2  myeloid zinc finger 1 isoform 1

    See identical proteins and their annotated locations for NP_003413.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF055077, BC007777, BQ446552, BU620994
    Consensus CDS
    CCDS12988.1
    UniProtKB/Swiss-Prot
    P28698
    UniProtKB/TrEMBL
    A0A024R4T5
    Related
    ENSP00000469493.1, ENST00000599369.5
    Conserved Domains (4) summary
    smart00431
    Location:40152
    SCAN; leucine rich region
    COG5048
    Location:358716
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:543563
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:442462
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_198055.1NP_932172.1  myeloid zinc finger 1 isoform 1

    See identical proteins and their annotated locations for NP_932172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AF055078, BC007777, BQ446552, BU620994
    Consensus CDS
    CCDS12988.1
    UniProtKB/Swiss-Prot
    P28698
    UniProtKB/TrEMBL
    A0A024R4T5
    Related
    ENSP00000215057.1, ENST00000215057.6
    Conserved Domains (4) summary
    smart00431
    Location:40152
    SCAN; leucine rich region
    COG5048
    Location:358716
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:543563
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:442462
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    58561917..58574478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527264.3XP_011525566.1  myeloid zinc finger 1 isoform X2

    Conserved Domains (7) summary
    smart00431
    Location:70182
    SCAN; leucine rich region
    COG5048
    Location:388746
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:573593
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:388408
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:70158
    SCAN; SCAN domain
    pfam13465
    Location:697722
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017027206.1XP_016882695.1  myeloid zinc finger 1 isoform X3

  3. XM_005259204.3XP_005259261.1  myeloid zinc finger 1 isoform X1

    See identical proteins and their annotated locations for XP_005259261.1

    UniProtKB/TrEMBL
    A0A024R4R6
    Conserved Domains (4) summary
    smart00431
    Location:81193
    SCAN; leucine rich region
    COG5048
    Location:399757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:483503
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_024451689.1XP_024307457.1  myeloid zinc finger 1 isoform X1

    Conserved Domains (4) summary
    smart00431
    Location:81193
    SCAN; leucine rich region
    COG5048
    Location:399757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:584604
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:483503
    ZF_C2H2; C2H2 Zn finger [structural motif]
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