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Mzf1 myeloid zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 109889, updated on 26-Sep-2022

Summary

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Official Symbol
Mzf1provided by MGI
Official Full Name
myeloid zinc finger 1provided by MGI
Primary source
MGI:MGI:107457
See related
Ensembl:ENSMUSG00000030380 AllianceGenome:MGI:107457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mzf2; Mzf-2; Zfp98; Znf42; Zfp121
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in bladder; male associated reproductive structure; testis; and urethra of male. Orthologous to human MZF1 (myeloid zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 1.8), frontal lobe adult (RPKM 1.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mzf1 in Genome Data Viewer
Location:
7 A1; 7 7.73 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12776230..12792244, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13042303..13054764, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 2A Neighboring gene ubiquitin-conjugating enzyme E2M Neighboring gene vomeronasal 1 receptor 85 Neighboring gene predicted gene 4270

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of myeloid zinc finger protein 2A transactivation activity through phosphorylation by mitogen-activated protein kinases. Ogawa H, et al. J Biol Chem, 2003 Jan 31. PMID 12427756
  2. Mzf1 controls cell proliferation and tumorigenesis. Gaboli M, et al. Genes Dev, 2001 Jul 1. PMID 11445537, Free PMC Article
  3. Myeloid-specific transcriptional activation by murine myeloid zinc-finger protein 2. Murai K, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520388, Free PMC Article
  4. A novel form of the myeloid-specific zinc finger protein (MZF-2). Murai K, et al. Genes Cells, 1997 Sep. PMID 9413999
  5. The transcription factor MZF1 differentially regulates murine Mtor promoter variants linked to tumor susceptibility. Zhang S, et al. J Biol Chem, 2019 Nov 8. PMID 31548308, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
    Title: Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
  2. MZF1 down-regulates Mtor expression in pristane-induced plasmacytomas in mice
    Title: The transcription factor MZF1 differentially regulates murine Mtor promoter variants linked to tumor susceptibility.
  3. TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
    Title: TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
  4. Findings implicate a novel, temporal-specific role of Mzf1 in embryonic heart development and show that Mzf1 bounds directly to the Nkx2.5 during murine embryonic stem cell differentiation.
    Title: Myeloid zinc finger 1 (Mzf1) differentially modulates murine cardiogenesis by interacting with an Nkx2.5 cardiac enhancer.
  5. Data conclude that sell transcription is regulated by Mzf1, Klf2, Sp1, Ets1, and Irf1.
    Title: Transcriptional regulation of mouse L-selectin.
  6. transactivation of this protein is regulated through phosphorylation by mitogen-activated protein kinases.
    Title: Regulation of myeloid zinc finger protein 2A transactivation activity through phosphorylation by mitogen-activated protein kinases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myeloid zinc finger 1
Names
Myeloid zinc finger protein 1
Myeloid zinc finger protein 2
myeloid-specific retinoic acid-responsive zinc finger protein
zinc finger protein 121
zinc finger protein 98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290452.1 → NP_001277381.1  myeloid zinc finger 1 isoform 2

    See identical proteins and their annotated locations for NP_001277381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC121301
    UniProtKB/TrEMBL
    A1L357
    Conserved Domains (5) summary
    COG5048
    Location:144 → 524
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:250 → 270
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:165 → 186
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:475 → 500
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001290453.1 → NP_001277382.1  myeloid zinc finger 1 isoform 3

    See identical proteins and their annotated locations for NP_001277382.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC121301, AK030410
    Conserved Domains (3) summary
    COG5048
    Location:74 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:180 → 200
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001382820.1 → NP_001369749.1  myeloid zinc finger 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121301
    Conserved Domains (1) summary
    smart00431
    Location:42 → 153
    SCAN; leucine rich region

  4. NM_145819.2 → NP_665818.2  myeloid zinc finger 1 isoform 1

    See identical proteins and their annotated locations for NP_665818.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC121301, BC129905
    Consensus CDS
    CCDS20826.1
    UniProtKB/TrEMBL
    A1L358
    Related
    ENSMUSP00000138387.2, ENSMUST00000182515.8
    Conserved Domains (7) summary
    smart00431
    Location:42 → 153
    SCAN; leucine rich region
    COG5048
    Location:337 → 728
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:544 → 564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:358 → 379
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:42 → 129
    SCAN; SCAN domain
    pfam13465
    Location:668 → 693
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12776230..12792244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539469.4 → XP_006539532.3  myeloid zinc finger 1 isoform X3

    Conserved Domains (1) summary
    smart00431
    Location:121 → 232
    SCAN; leucine rich region

  2. XM_006539465.5 → XP_006539528.1  myeloid zinc finger 1 isoform X1

    See identical proteins and their annotated locations for XP_006539528.1

    UniProtKB/TrEMBL
    S4R1L6
    Related
    ENSMUSP00000138271.2, ENSMUST00000182490.2
    Conserved Domains (4) summary
    smart00431
    Location:121 → 232
    SCAN; leucine rich region
    COG5048
    Location:416 → 807
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623 → 643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030241983.2 → XP_030097843.1  myeloid zinc finger 1 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:74 → 454
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281 → 301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:180 → 200
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_006539466.5 → XP_006539529.1  myeloid zinc finger 1 isoform X2

    Conserved Domains (4) summary
    smart00431
    Location:64 → 175
    SCAN; leucine rich region
    COG5048
    Location:359 → 750
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566 → 586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:465 → 485
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_030241985.2 → XP_030097845.1  myeloid zinc finger 1 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:5 → 364
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191 → 211
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_017321928.3 → XP_017177417.1  myeloid zinc finger 1 isoform X6

    Conserved Domains (1) summary
    smart00431
    Location:121 → 232
    SCAN; leucine rich region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016793.1: Suppressed sequence

    Description
    NM_016793.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

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