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ZSCAN21 zinc finger and SCAN domain containing 21 [ Homo sapiens (human) ]

Gene ID: 7589, updated on 9-Feb-2020

Summary

Official Symbol
ZSCAN21provided by HGNC
Official Full Name
zinc finger and SCAN domain containing 21provided by HGNC
Primary source
HGNC:HGNC:13104
See related
Ensembl:ENSG00000166529 MIM:601261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF38; Zipro1; NY-REN-21
Expression
Ubiquitous expression in testis (RPKM 4.9), endometrium (RPKM 3.1) and 25 other tissues See more
Orthologs

Genomic context

See ZSCAN21 in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (100049774..100065041)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99647390..99662663)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375423 Neighboring gene zinc finger with KRAB and SCAN domains 1 Neighboring gene zinc finger protein 3 Neighboring gene COP9 signalosome subunit 6 Neighboring gene microRNA 25 Neighboring gene minichromosome maintenance complex component 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434L134, DKFZp686H10254

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 21
Names
renal carcinoma antigen NY-REN-21
zfp-38
zinc finger protein 38 (KOX 25)
zinc finger protein 38 homolog
zinc finger protein NY-REN-21 antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362779.1NP_001349708.1  zinc finger and SCAN domain-containing protein 21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093619, BC047309, BI764964, BM991519
    Conserved Domains (4) summary
    smart00431
    Location:42153
    SCAN; leucine rich region
    COG5048
    Location:276453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:446466
    zf-C2H2; Zinc finger, C2H2 type
  2. NM_001362780.1NP_001349709.1  zinc finger and SCAN domain-containing protein 21 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093619, BC047309, BI764964, BM991519
    Consensus CDS
    CCDS5681.1
    Conserved Domains (4) summary
    smart00431
    Location:42153
    SCAN; leucine rich region
    COG5048
    Location:276453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:446466
    zf-C2H2; Zinc finger, C2H2 type
  3. NM_001362781.2NP_001349710.1  zinc finger and SCAN domain-containing protein 21 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093619, BC047309, BI764964, BM991519
    Consensus CDS
    CCDS87526.1
    Related
    ENSP00000390960.2, ENST00000456748.6
    Conserved Domains (1) summary
    smart00431
    Location:42153
    SCAN; leucine rich region
  4. NM_145914.3NP_666019.1  zinc finger and SCAN domain-containing protein 21 isoform 1

    See identical proteins and their annotated locations for NP_666019.1

    Status: VALIDATED

    Source sequence(s)
    AC093619, BC047309, BI764964, BM991519
    Consensus CDS
    CCDS5681.1
    UniProtKB/Swiss-Prot
    Q9Y5A6
    Related
    ENSP00000292450.4, ENST00000292450.9
    Conserved Domains (4) summary
    smart00431
    Location:42153
    SCAN; leucine rich region
    COG5048
    Location:276453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:446466
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    100049774..100065041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716113.3XP_006716176.1  zinc finger and SCAN domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_006716176.1

    UniProtKB/Swiss-Prot
    Q9Y5A6
    Conserved Domains (4) summary
    smart00431
    Location:42153
    SCAN; leucine rich region
    COG5048
    Location:276453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:446466
    zf-C2H2; Zinc finger, C2H2 type
  2. XM_005250568.4XP_005250625.1  zinc finger and SCAN domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_005250625.1

    UniProtKB/Swiss-Prot
    Q9Y5A6
    Conserved Domains (4) summary
    smart00431
    Location:42153
    SCAN; leucine rich region
    COG5048
    Location:276453
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:446466
    zf-C2H2; Zinc finger, C2H2 type
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