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Zscan21 zinc finger and SCAN domain containing 21 [ Mus musculus (house mouse) ]

Gene ID: 22697, updated on 12-May-2024

Summary

Official Symbol
Zscan21provided by MGI
Official Full Name
zinc finger and SCAN domain containing 21provided by MGI
Primary source
MGI:MGI:99182
See related
Ensembl:ENSMUSG00000037017 AllianceGenome:MGI:99182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RU49; Zfp38; Zfp-38; Zipro1; CTfin51
Summary
Enables DNA binding activity. Involved in male meiosis I and spermatogenesis. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut gland; liver and biliary system; and nervous system. Orthologous to human ZSCAN21 (zinc finger and SCAN domain containing 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 21.4), CNS E14 (RPKM 21.2) and 28 other tissues See more
Orthologs
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Genomic context

See Zscan21 in Genome Data Viewer
Location:
5 G2; 5 76.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138115161..138132527)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138116899..138134265)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sperm motility kinase 3C Neighboring gene zinc finger with KRAB and SCAN domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E8086 Neighboring gene zinc finger protein 113 Neighboring gene STARR-positive B cell enhancer ABC_E4799 Neighboring gene STARR-positive B cell enhancer ABC_E9656 Neighboring gene COP9 signalosome subunit 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 21
Names
transcription factor RU49
zinc finger proliferation 1
zinc finger protein 38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044703.2NP_001038168.1  zinc finger and SCAN domain-containing protein 21

    See identical proteins and their annotated locations for NP_001038168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1,2,3 and 4 encode the same protein.
    Source sequence(s)
    AI326272, AK146875, BY293243, BY309906, BY654936, DV651309
    Consensus CDS
    CCDS19790.1
    UniProtKB/Swiss-Prot
    Q07231, Q921V2
    Related
    ENSMUSP00000106585.3, ENSMUST00000110960.9
    Conserved Domains (4) summary
    smart00431
    Location:118230
    SCAN; leucine rich region
    COG5048
    Location:339535
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528548
    zf-C2H2; Zinc finger, C2H2 type
  2. NM_001044704.2NP_001038169.1  zinc finger and SCAN domain-containing protein 21

    See identical proteins and their annotated locations for NP_001038169.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1,2,3 and 4 encode the same protein.
    Source sequence(s)
    AI326272, AK146776, AK146875, BY293243, BY654936, CF915830, DV651309
    Consensus CDS
    CCDS19790.1
    UniProtKB/Swiss-Prot
    Q07231, Q921V2
    Related
    ENSMUSP00000053430.9, ENSMUST00000062350.15
    Conserved Domains (4) summary
    smart00431
    Location:118230
    SCAN; leucine rich region
    COG5048
    Location:339535
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528548
    zf-C2H2; Zinc finger, C2H2 type
  3. NM_001044705.2NP_001038170.1  zinc finger and SCAN domain-containing protein 21

    See identical proteins and their annotated locations for NP_001038170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1,2,3 and 4 encode the same protein.
    Source sequence(s)
    AI326272, AK146875, BY293243, BY309906, BY654936, DV651309
    Consensus CDS
    CCDS19790.1
    UniProtKB/Swiss-Prot
    Q07231, Q921V2
    Related
    ENSMUSP00000079557.4, ENSMUST00000080732.10
    Conserved Domains (4) summary
    smart00431
    Location:118230
    SCAN; leucine rich region
    COG5048
    Location:339535
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528548
    zf-C2H2; Zinc finger, C2H2 type
  4. NM_011757.3NP_035887.2  zinc finger and SCAN domain-containing protein 21

    See identical proteins and their annotated locations for NP_035887.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1,2,3 and 4 encode the same protein.
    Source sequence(s)
    AI326272, AK146875, BY293243, BY654936, DV651309
    Consensus CDS
    CCDS19790.1
    UniProtKB/Swiss-Prot
    Q07231, Q921V2
    Related
    ENSMUSP00000106586.3, ENSMUST00000110961.9
    Conserved Domains (4) summary
    smart00431
    Location:118230
    SCAN; leucine rich region
    COG5048
    Location:339535
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528548
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138115161..138132527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240942.1XP_011239244.1  zinc finger and SCAN domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011239244.1

    UniProtKB/Swiss-Prot
    Q07231, Q921V2
    Conserved Domains (4) summary
    smart00431
    Location:118230
    SCAN; leucine rich region
    COG5048
    Location:339535
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:472492
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528548
    zf-C2H2; Zinc finger, C2H2 type