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Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 75669, updated on 21-Apr-2024

Summary

Official Symbol
Pik3r4provided by MGI
Official Full Name
phosphoinositide-3-kinase regulatory subunit 4provided by MGI
Primary source
MGI:MGI:1922919
See related
Ensembl:ENSMUSG00000032571 AllianceGenome:MGI:1922919
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p150; Vps15; D9Ertd418e; 2210010O15Rik; C730038E05Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in cellular response to glucose starvation. Located in axoneme. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in central nervous system; embryo; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 8.1), spleen adult (RPKM 7.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
9 F1; 9 56.79 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (105520156..105564854)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (105642995..105687655)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25126 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 pseudogene Neighboring gene predicted gene 5621 Neighboring gene STARR-seq mESC enhancer starr_25127 Neighboring gene STARR-seq mESC enhancer starr_25130 Neighboring gene STARR-seq mESC enhancer starr_25131 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:105591833-105592016 Neighboring gene predicted gene, 22720 Neighboring gene collagen, type VI, alpha 6 Neighboring gene STARR-seq mESC enhancer starr_25132 Neighboring gene STARR-seq mESC enhancer starr_25133 Neighboring gene collagen, type VI, alpha 5 Neighboring gene STARR-seq mESC enhancer starr_25134

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein targeting to lysosome NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus-vacuole junction IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phosphatidylinositol 3-kinase complex, class III IDA
Inferred from Direct Assay
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class III ISO
Inferred from Sequence Orthology
more info
 
part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phosphoinositide 3-kinase regulatory subunit 4
Names
PI3-kinase regulatory subunit 4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
NP_001074778.1
XP_036011263.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081309.1NP_001074778.1  phosphoinositide 3-kinase regulatory subunit 4

    See identical proteins and their annotated locations for NP_001074778.1

    Status: PROVISIONAL

    Source sequence(s)
    AC157514
    Consensus CDS
    CCDS40753.1
    UniProtKB/Swiss-Prot
    Q56A65, Q8C948, Q8C9D7, Q8VD65, Q9CVC5
    UniProtKB/TrEMBL
    B2RXR2
    Related
    ENSMUSP00000067400.7, ENSMUST00000065778.13
    Conserved Domains (8) summary
    smart00320
    Location:13271358
    WD40; WD40 repeats
    COG2319
    Location:9911358
    WD40; WD40 repeat [General function prediction only]
    cd13980
    Location:25320
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    pfam00069
    Location:26309
    Pkinase; Protein kinase domain
    pfam07539
    Location:352449
    DRIM; Down-regulated in metastasis
    sd00044
    Location:539566
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:9971040
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:9851269
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    105520156..105564854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155370.1XP_036011263.1  phosphoinositide 3-kinase regulatory subunit 4 isoform X1

    UniProtKB/TrEMBL
    B2RXR2
    Conserved Domains (5) summary
    smart00320
    Location:13351366
    WD40; WD40 repeats
    cd13980
    Location:25320
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    sd00044
    Location:539566
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:10051048
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:9931277
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_029380.1: Suppressed sequence

    Description
    NM_029380.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.