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PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 [ Homo sapiens (human) ]

Gene ID: 30849, updated on 28-Nov-2021

Summary

Official Symbol
PIK3R4provided by HGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 4provided by HGNC
Primary source
HGNC:HGNC:8982
See related
Ensembl:ENSG00000196455 MIM:602610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p150; VPS15
Expression
Ubiquitous expression in thyroid (RPKM 9.2), testis (RPKM 8.7) and 25 other tissues See more
Orthologs
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Genomic context

See PIK3R4 in Genome Data Viewer
Location:
3q22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (130678934..130746829, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (130397778..130465673, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene collagen type VI alpha 5 chain Neighboring gene collagen type VI alpha 6 chain Neighboring gene uncharacterized LOC107986023 Neighboring gene uncharacterized LOC105374107 Neighboring gene RN7SK pseudogene 212 Neighboring gene glutathione S-transferase omega 3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102700

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in autophagosome maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in early endosome to late endosome transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
 
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus-vacuole junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
part_of phosphatidylinositol 3-kinase complex, class III IPI
Inferred from Physical Interaction
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class III ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphoinositide 3-kinase regulatory subunit 4
Names
PI3-kinase p150 subunit
PI3-kinase regulatory subunit 4
phosphatidylinositol 3-kinase-associated p150
phosphoinositide 3-kinase adaptor protein
phosphoinositide-3-kinase, regulatory subunit 4, p150
NP_055417.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014602.3NP_055417.1  phosphoinositide 3-kinase regulatory subunit 4

    See identical proteins and their annotated locations for NP_055417.1

    Status: VALIDATED

    Source sequence(s)
    BP359657, Y08991
    Consensus CDS
    CCDS3067.1
    UniProtKB/Swiss-Prot
    Q99570
    Related
    ENSP00000349205.3, ENST00000356763.8
    Conserved Domains (8) summary
    smart00320
    Location:13271358
    WD40; WD40 repeats
    smart00220
    Location:26309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG2319
    Location:9911358
    WD40; WD40 repeat [General function prediction only]
    cd13980
    Location:25320
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    pfam07539
    Location:352448
    DRIM; Down-regulated in metastasis
    sd00044
    Location:539566
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:9971040
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:9851269
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    130678934..130746829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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