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ZFY zinc finger protein Y-linked [ Homo sapiens (human) ]

Gene ID: 7544, updated on 9-Dec-2018

Summary

Official Symbol
ZFYprovided by HGNC
Official Full Name
zinc finger protein Y-linkedprovided by HGNC
Primary source
HGNC:HGNC:12870
See related
Ensembl:ENSG00000067646 MIM:490000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF911
Summary
This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]
Annotation information
Note: This gene is annotated on the Y chromosome of the reference genome and HuRef assemblies but is annotated on the X chromosome of the Celera assembly (as gene LOC100130829 and model XM_001713692.1). [18 Feb 2009]
Expression
Broad expression in testis (RPKM 3.4), prostate (RPKM 3.2) and 20 other tissues See more
Orthologs

Genomic context

See ZFY in Genome Data Viewer
Location:
Yp11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) Y NC_000024.10 (2934402..2982508)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (2803112..2850547)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor Y-linked 3, pseudogene Neighboring gene nucleosome assembly protein 1 like 1 pseudogene 2 Neighboring gene ZFY antisense RNA 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 41 Neighboring gene long intergenic non-protein coding RNA 278

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger Y-chromosomal protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008113.1 RefSeqGene

    Range
    4973..52002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145275.1NP_001138747.1  zinc finger Y-chromosomal protein isoform 2

    See identical proteins and their annotated locations for NP_001138747.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) omits two coding exons compared to variant 1. The resulting predicted protein (isoform 2) is shorter.
    Source sequence(s)
    AC006157, AI763177, AL137603, BC114526, BC114960
    Consensus CDS
    CCDS48201.1
    UniProtKB/Swiss-Prot
    P08048
    Related
    ENSP00000393908.1, ENST00000449237.4
    Conserved Domains (6) summary
    COG5048
    Location:462599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:467489
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45329
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:481503
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:346362
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  2. NM_001145276.1NP_001138748.1  zinc finger Y-chromosomal protein isoform 3

    See identical proteins and their annotated locations for NP_001138748.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate 5'UTR exon and omits an in-frame coding exon, compared to variant 1, resulting in a shorter protein (isoform 3).
    Source sequence(s)
    AC006157, AK301061, AK310553, AL137603, BC114526
    Consensus CDS
    CCDS48200.1
    UniProtKB/Swiss-Prot
    P08048
    Related
    ENSP00000485605.1, ENST00000625061.3
    Conserved Domains (5) summary
    COG5048
    Location:348485
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:295315
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:22215
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:367389
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:232248
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  3. NM_003411.4NP_003402.2  zinc finger Y-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_003402.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC006157, AI469059, AI763177, AL137603, BC114526, M30607
    Consensus CDS
    CCDS14774.1
    UniProtKB/Swiss-Prot
    P08048
    Related
    ENSP00000155093.3, ENST00000155093.7
    Conserved Domains (6) summary
    COG5048
    Location:539676
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:544566
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71406
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:558580
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:423439
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p12 Primary Assembly

    Range
    2934402..2982508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017030077.1XP_016885566.1  zinc finger Y-chromosomal protein isoform X4

    UniProtKB/Swiss-Prot
    P08048
    Conserved Domains (6) summary
    COG5048
    Location:462599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:467489
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45329
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:481503
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:346362
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  2. XM_011531475.3XP_011529777.1  zinc finger Y-chromosomal protein isoform X3

    Conserved Domains (6) summary
    COG5048
    Location:488625
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435455
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:493515
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71355
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:507529
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:372388
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  3. XM_011531473.2XP_011529775.1  zinc finger Y-chromosomal protein isoform X2

    See identical proteins and their annotated locations for XP_011529775.1

    Conserved Domains (6) summary
    COG5048
    Location:513650
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518540
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45380
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:532554
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:397413
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  4. XM_011531474.2XP_011529776.1  zinc finger Y-chromosomal protein isoform X2

    See identical proteins and their annotated locations for XP_011529776.1

    Conserved Domains (6) summary
    COG5048
    Location:513650
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518540
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45380
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:532554
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:397413
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  5. XM_005262570.2XP_005262627.1  zinc finger Y-chromosomal protein isoform X1

    See identical proteins and their annotated locations for XP_005262627.1

    UniProtKB/Swiss-Prot
    P08048
    Related
    ENSP00000372525.1, ENST00000383052.5
    Conserved Domains (6) summary
    COG5048
    Location:539676
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:544566
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71406
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:558580
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:423439
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  6. XM_017030076.1XP_016885565.1  zinc finger Y-chromosomal protein isoform X3

    Conserved Domains (6) summary
    COG5048
    Location:488625
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435455
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:493515
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71355
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:507529
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:372388
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  7. XM_017030075.1XP_016885564.1  zinc finger Y-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P08048
    Conserved Domains (6) summary
    COG5048
    Location:539676
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:486506
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:544566
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71406
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:558580
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:423439
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
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