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YES1 YES proto-oncogene 1, Src family tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 7525, updated on 4-Nov-2018

Summary

Official Symbol
YES1provided by HGNC
Official Full Name
YES proto-oncogene 1, Src family tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:12841
See related
Ensembl:ENSG00000176105 MIM:164880; Vega:OTTHUMG00000131472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Yes; c-yes; HsT441; P61-YES
Summary
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues See more
Orthologs

Genomic context

See YES1 in Genome Data Viewer
Location:
18p11.32
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (721592..812846, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (721592..812327, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene clusterin like 1 Neighboring gene TYMS opposite strand Neighboring gene thymidylate synthetase Neighboring gene enolase superfamily member 1 Neighboring gene RNA, U1 small nuclear 109, pseudogene Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
T cell costimulation TAS
Traceable Author Statement
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of vascular permeability TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
actin filament IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic specialization, intracellular component IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein kinase Yes
Names
YES1 proto-oncogene, Src family tyrosine kinase
Yamaguchi sarcoma oncogene
cellular yes-1 protein
proto-oncogene c-Yes
proto-oncogene tyrosine-protein kinase YES
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
NP_005424.1
XP_005258196.1
XP_016881449.1
XP_024307011.1
XP_024307012.1
XP_024307013.1
XP_024307014.1
XP_024307015.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005433.3NP_005424.1  tyrosine-protein kinase Yes

    See identical proteins and their annotated locations for NP_005424.1

    Status: REVIEWED

    Source sequence(s)
    AU123956, BC031080, BC048960, BU753688, H80401, M15990
    Consensus CDS
    CCDS11824.1
    UniProtKB/Swiss-Prot
    P07947
    Related
    ENSP00000324740.4, OTTHUMP00000259023, ENST00000314574.4, OTTHUMT00000441337
    Conserved Domains (3) summary
    cd09933
    Location:154253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    721592..812846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451244.1XP_024307012.1  tyrosine-protein kinase Yes isoform X1

    Conserved Domains (3) summary
    cd09933
    Location:154253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
  2. XM_024451243.1XP_024307011.1  tyrosine-protein kinase Yes isoform X1

    Related
    ENSP00000462468.1, ENST00000584307.5
    Conserved Domains (3) summary
    cd09933
    Location:154253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
  3. XM_024451247.1XP_024307015.1  tyrosine-protein kinase Yes isoform X2

    Conserved Domains (3) summary
    cd09933
    Location:154253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cl21453
    Location:264498
    PKc_like; Protein Kinases, catalytic domain
  4. XM_024451246.1XP_024307014.1  tyrosine-protein kinase Yes isoform X1

    Conserved Domains (3) summary
    cd09933
    Location:154253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
  5. XM_005258139.4XP_005258196.1  tyrosine-protein kinase Yes isoform X2

    See identical proteins and their annotated locations for XP_005258196.1

    Conserved Domains (3) summary
    cd09933
    Location:154253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cl21453
    Location:264498
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017025960.2XP_016881449.1  tyrosine-protein kinase Yes isoform X1

    UniProtKB/Swiss-Prot
    P07947
    Related
    OTTHUMP00000258690
    Conserved Domains (3) summary
    cd09933
    Location:154253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
  7. XM_024451245.1XP_024307013.1  tyrosine-protein kinase Yes isoform X1

    Related
    ENSP00000464380.1, ENST00000577961.5
    Conserved Domains (3) summary
    cd09933
    Location:154253
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:94151
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:264542
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
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