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Yes1 YES proto-oncogene 1, Src family tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 22612, updated on 8-Dec-2022

Summary

Official Symbol
Yes1provided by MGI
Official Full Name
YES proto-oncogene 1, Src family tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:99147
See related
Ensembl:ENSMUSG00000014932 AllianceGenome:MGI:99147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Yes; p61-Yes
Summary
Predicted to enable several functions, including non-membrane spanning protein tyrosine kinase activity; phosphotyrosine residue binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including cellular response to growth factor stimulus; cellular response to retinoic acid; and positive regulation of nitrogen compound metabolic process. Located in actin filament and plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; pancreas; placenta; and vagal nerve trunk. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.0), CNS E11.5 (RPKM 3.5) and 27 other tissues See more
Orthologs
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Genomic context

See Yes1 in Genome Data Viewer
Location:
5 B1; 5 17.33 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32768502..32844410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32611171..32687066)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 catalytic subunit beta Neighboring gene predicted gene 15614 Neighboring gene methyltransferase-like protein 4 pseudogene Neighboring gene predicted gene 10461 Neighboring gene predicted gene 2420 Neighboring gene predicted gene, 52771 Neighboring gene phosphatidylserine decarboxylase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization, intracellular component ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tyrosine-protein kinase Yes
Names
Yamaguchi sarcoma viral (v-yes) oncogene homolog 1
proto-oncogene c-Yes
proto-oncogene tyrosine-protein kinase Yes
viral oncogene yes homolog
NP_001192061.1
NP_001192062.1
NP_033561.1
XP_036020892.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205132.1NP_001192061.1  tyrosine-protein kinase Yes

    See identical proteins and their annotated locations for NP_001192061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC091274, AC166934
    Consensus CDS
    CCDS39061.1
    UniProtKB/Swiss-Prot
    Q04736
    UniProtKB/TrEMBL
    A0A8C6HQY7, Q3TJI7
    Related
    ENSMUSP00000144001.2, ENSMUST00000202543.4
    Conserved Domains (4) summary
    cd09933
    Location:152251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:262540
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    pfam07714
    Location:275524
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001205133.1NP_001192062.1  tyrosine-protein kinase Yes

    See identical proteins and their annotated locations for NP_001192062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in both the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC091274, AC166934
    Consensus CDS
    CCDS39061.1
    UniProtKB/Swiss-Prot
    Q04736
    UniProtKB/TrEMBL
    A0A8C6HQY7, Q3TJI7
    Related
    ENSMUSP00000132161.3, ENSMUST00000168707.6
    Conserved Domains (4) summary
    cd09933
    Location:152251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:262540
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    pfam07714
    Location:275524
    Pkinase_Tyr; Protein tyrosine kinase
  3. NM_009535.3NP_033561.1  tyrosine-protein kinase Yes

    See identical proteins and their annotated locations for NP_033561.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC091274, AC166934, AK167420
    Consensus CDS
    CCDS39061.1
    UniProtKB/Swiss-Prot
    Q04736
    UniProtKB/TrEMBL
    A0A8C6HQY7, Q3TJI7
    Related
    ENSMUSP00000072154.7, ENSMUST00000072311.13
    Conserved Domains (4) summary
    cd09933
    Location:152251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cd05069
    Location:262540
    PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
    pfam07714
    Location:275524
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    32768502..32844410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164999.1XP_036020892.1  tyrosine-protein kinase Yes isoform X1

    Conserved Domains (3) summary
    cd09933
    Location:152251
    SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
    cd12007
    Location:92149
    SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase
    cl21453
    Location:262351
    PKc_like; Protein Kinases, catalytic domain