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EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Pan troglodytes (chimpanzee) ]

Gene ID: 745437, updated on 17-Aug-2024

Summary

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Official Symbol
EZH2provided by VGNC
Official Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by VGNC
Primary source
VGNC:VGNC:4343
Locus tag
CK820_G0014218
See related
Ensembl:ENSPTRG00000019837
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 6 NC_072404.2 (163959789..164036418, complement)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 7 NC_072405.1 (158029287..158107088, complement)

Chromosome 6 - NC_072404.2Genomic Context describing neighboring genes Neighboring gene huntingtin-interacting protein K-like Neighboring gene cullin 1 Neighboring gene U7 small nuclear RNA Neighboring gene U6 spliceosomal RNA Neighboring gene protein disulfide isomerase family A member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K27 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase EZH2
Names
enhancer of zeste homolog 2
XP_009452721.1
XP_009452723.1
XP_009452726.1
XP_009452728.1
XP_016800891.1
XP_016800894.1
XP_016800897.1
XP_016813835.3
XP_024213837.1
XP_054512305.1
XP_054512309.1
XP_054512310.1
XP_063671809.1
XP_063671810.1
XP_063671811.1
XP_063671812.1
XP_063671813.1
XP_063671814.1
XP_063671815.1
XP_063671816.1
XP_063671817.1
XP_063671818.1
XP_063671819.1
XP_063671820.1
XP_063671821.1
XP_063671822.1
XP_063671823.1
XP_063671824.1
XP_063671825.1
XP_063671826.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    163959789..164036418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054656335.2 → XP_054512310.1  histone-lysine N-methyltransferase EZH2 isoform X22

    UniProtKB/TrEMBL
    A0A2I3SPJ8, A0A2J8QUN7, A0A6D2XJX0, H2QVK6

  2. XM_016945402.4 → XP_016800891.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A2J8QUN6, A0A803KHR1, H2QVK6, K7C3W4
    Related
    ENSPTRP00000077344.1
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  3. XM_016945405.4 → XP_016800894.1  histone-lysine N-methyltransferase EZH2 isoform X10

    UniProtKB/TrEMBL
    A0A2J8QUQ0, A0A803KIB7, H2QVK6, K7D987
    Conserved Domains (4) summary
    cd19218
    Location:600 → 719
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:550 → 581
    preSET_CXC; CXC domain

  4. XM_063815749.1 → XP_063671819.1  histone-lysine N-methyltransferase EZH2 isoform X19

    UniProtKB/TrEMBL
    H2QVK6

  5. XM_063815748.1 → XP_063671818.1  histone-lysine N-methyltransferase EZH2 isoform X17

    UniProtKB/TrEMBL
    H2QVK6

  6. XM_009454448.5 → XP_009452723.1  histone-lysine N-methyltransferase EZH2 isoform X4

    See identical proteins and their annotated locations for XP_009452723.1

    UniProtKB/TrEMBL
    A0A2I3TMI4, A0A2J8QUN8, A0A6D2XJ78, H2QVK6
    Related
    ENSPTRP00000090461.1
    Conserved Domains (4) summary
    cd19218
    Location:614 → 733
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:564 → 595
    preSET_CXC; CXC domain

  7. XM_063815755.1 → XP_063671825.1  histone-lysine N-methyltransferase EZH2 isoform X26

    UniProtKB/TrEMBL
    H2QVK6

  8. XM_016945408.4 → XP_016800897.1  histone-lysine N-methyltransferase EZH2 isoform X18

    UniProtKB/TrEMBL
    A0A2J8QUP5, A0A6D2VWU9, H2QVK6, K7DDW8
    Conserved Domains (4) summary
    cd19218
    Location:570 → 689
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:119 → 210
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:520 → 551
    preSET_CXC; CXC domain

  9. XM_063815752.1 → XP_063671822.1  histone-lysine N-methyltransferase EZH2 isoform X24

    UniProtKB/TrEMBL
    H2QVK6

  10. XM_063815746.1 → XP_063671816.1  histone-lysine N-methyltransferase EZH2 isoform X15

    UniProtKB/TrEMBL
    H2QVK6

  11. XM_054656334.2 → XP_054512309.1  histone-lysine N-methyltransferase EZH2 isoform X13

    UniProtKB/TrEMBL
    H2QVK6

  12. XM_009454451.5 → XP_009452726.1  histone-lysine N-methyltransferase EZH2 isoform X8

    See identical proteins and their annotated locations for XP_009452726.1

    UniProtKB/TrEMBL
    H2QVK6
    Conserved Domains (4) summary
    cd19218
    Location:605 → 724
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:555 → 586
    preSET_CXC; CXC domain

  13. XM_063815745.1 → XP_063671815.1  histone-lysine N-methyltransferase EZH2 isoform X12

    UniProtKB/TrEMBL
    A0A2J8QUQ4

  14. XM_063815744.1 → XP_063671814.1  histone-lysine N-methyltransferase EZH2 isoform X11

    UniProtKB/TrEMBL
    A0A2J8QUQ4

  15. XM_063815751.1 → XP_063671821.1  histone-lysine N-methyltransferase EZH2 isoform X21

    UniProtKB/TrEMBL
    H2QVK6

  16. XM_063815743.1 → XP_063671813.1  histone-lysine N-methyltransferase EZH2 isoform X9

    UniProtKB/TrEMBL
    A0A2J8QUQ4

  17. XM_063815742.1 → XP_063671812.1  histone-lysine N-methyltransferase EZH2 isoform X7

    UniProtKB/TrEMBL
    A0A2J8QUQ4

  18. XM_063815747.1 → XP_063671817.1  histone-lysine N-methyltransferase EZH2 isoform X16

    UniProtKB/TrEMBL
    H2QVK6

  19. XM_063815753.1 → XP_063671823.1  histone-lysine N-methyltransferase EZH2 isoform X25

    UniProtKB/TrEMBL
    H2QVK6

  20. XM_063815756.1 → XP_063671826.1  histone-lysine N-methyltransferase EZH2 isoform X26

    UniProtKB/TrEMBL
    H2QVK6

  21. XM_063815754.1 → XP_063671824.1  histone-lysine N-methyltransferase EZH2 isoform X25

    UniProtKB/TrEMBL
    H2QVK6

  22. XM_063815740.1 → XP_063671810.1  histone-lysine N-methyltransferase EZH2 isoform X2

    UniProtKB/TrEMBL
    A0A2I3SK33, H2QVK6

  23. XM_009454446.5 → XP_009452721.1  histone-lysine N-methyltransferase EZH2 isoform X2

    See identical proteins and their annotated locations for XP_009452721.1

    UniProtKB/TrEMBL
    A0A2I3SK33, H2QVK6
    Conserved Domains (4) summary
    cd19218
    Location:617 → 736
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:47 → 76
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:166 → 257
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:567 → 598
    preSET_CXC; CXC domain

  24. XM_009454453.5 → XP_009452728.1  histone-lysine N-methyltransferase EZH2 isoform X14

    See identical proteins and their annotated locations for XP_009452728.1

    UniProtKB/TrEMBL
    H2QVK6
    Conserved Domains (2) summary
    smart00317
    Location:583 → 704
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:47 → 75
    EZH2_WD-Binding; WD repeat binding protein EZH2

  25. XM_054656330.2 → XP_054512305.1  histone-lysine N-methyltransferase EZH2 isoform X6

    UniProtKB/TrEMBL
    H2QVK6

  26. XM_063815741.1 → XP_063671811.1  histone-lysine N-methyltransferase EZH2 isoform X6

    UniProtKB/TrEMBL
    H2QVK6

  27. XM_063815750.1 → XP_063671820.1  histone-lysine N-methyltransferase EZH2 isoform X20

    UniProtKB/TrEMBL
    H2QVK6

  28. XM_063815739.1 → XP_063671809.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    H2QVK6

  29. XM_024358069.3 → XP_024213837.1  histone-lysine N-methyltransferase EZH2 isoform X23

    UniProtKB/TrEMBL
    A0A2I3SC22, H2QVK6
    Conserved Domains (4) summary
    cd19218
    Location:528 → 647
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:119 → 210
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:478 → 509
    preSET_CXC; CXC domain

  30. XM_016958346.4 → XP_016813835.3  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    H2QVK6

RNA

  1. XR_010159047.1 RNA Sequence

  2. XR_010159039.1 RNA Sequence

  3. XR_010159037.1 RNA Sequence

  4. XR_008536544.2 RNA Sequence

  5. XR_010159044.1 RNA Sequence

  6. XR_010159043.1 RNA Sequence

  7. XR_010159042.1 RNA Sequence

  8. XR_010159036.1 RNA Sequence

  9. XR_010159046.1 RNA Sequence

  10. XR_010159040.1 RNA Sequence

  11. XR_010159041.1 RNA Sequence

  12. XR_010159045.1 RNA Sequence

  13. XR_681670.5 RNA Sequence

  14. XR_010159038.1 RNA Sequence

Nucleotide Protein
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