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EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Homo sapiens (human) ]

Gene ID: 2146, updated on 27-Nov-2022

Summary

Official Symbol
EZH2provided by HGNC
Official Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by HGNC
Primary source
HGNC:HGNC:3527
See related
Ensembl:ENSG00000106462 MIM:601573; AllianceGenome:HGNC:3527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A
Summary
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.6) and 14 other tissues See more
Orthologs
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Genomic context

See EZH2 in Genome Data Viewer
Location:
7q36.1
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (148807383..148884291, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (149989157..150066070, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148504475..148581383, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene cullin 1 Neighboring gene RNA, U7 small nuclear 20 pseudogene Neighboring gene Sharpr-MPRA regulatory region 2848 Neighboring gene uncharacterized LOC124901767 Neighboring gene RNA, 7SL, cytoplasmic 569, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies enhancer of zeste homolog 2 (EZH2) is important for HIV-1 replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces EZH2 phophorylation in an Akt1 dependent manner PubMed
tat HIV-1 Tat decreases EZH2 levels on the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9169

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K27 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone H3K27 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K27 methyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables histone lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lncRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables primary miRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
 
involved_in G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to trichostatin A IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellar cortex development IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization TAS
Traceable Author Statement
more info
 
involved_in facultative heterochromatin formation IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hippocampus development IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-K27 trimethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytokine production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
involved_in negative regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of retinoic acid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to chromatin IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gliogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to tetrachloromethane IEA
Inferred from Electronic Annotation
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in subtelomeric heterochromatin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin silencing complex IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
 
located_in pronucleus IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase EZH2
Names
enhancer of zeste homolog 2
lysine N-methyltransferase 6
NP_001190176.1
NP_001190177.1
NP_001190178.1
NP_004447.2
NP_694543.1
XP_005250019.1
XP_005250020.1
XP_005250021.1
XP_011514185.1
XP_011514187.1
XP_011514189.1
XP_011514191.1
XP_011514192.1
XP_011514194.1
XP_011514195.1
XP_011514196.1
XP_011514197.1
XP_011514198.1
XP_011514201.1
XP_011514203.1
XP_016867306.1
XP_016867308.1
XP_016867309.1
XP_047275945.1
XP_047275946.1
XP_047275947.1
XP_047275948.1
XP_047275949.1
XP_047275950.1
XP_047275951.1
XP_047275952.1
XP_047275953.1
XP_047275954.1
XP_047275955.1
XP_047275956.1
XP_047275957.1
XP_047275958.1
XP_047275960.1
XP_047275961.1
XP_047275962.1
XP_047275963.1
XP_047275964.1
XP_047275965.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032043.1 RefSeqGene

    Range
    5001..81978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_531

mRNA and Protein(s)

  1. NM_001203247.2NP_001190176.1  histone-lysine N-methyltransferase EZH2 isoform c

    See identical proteins and their annotated locations for NP_001190176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (c) lacks one internal segment, as compared to isoform a.
    Source sequence(s)
    BC010858, BU953788, CN283479, U61145
    Consensus CDS
    CCDS56516.1
    UniProtKB/Swiss-Prot
    Q15910, Q96FI6
    Related
    ENSP00000419711.1, ENST00000460911.5
    Conserved Domains (4) summary
    cd19218
    Location:609728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559590
    preSET_CXC; CXC domain
  2. NM_001203248.2NP_001190177.1  histone-lysine N-methyltransferase EZH2 isoform d

    See identical proteins and their annotated locations for NP_001190177.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame segments in the coding region, as compared to variant 1. The resulting isoform (d) lacks two internal segments, as compared to isoform a.
    Source sequence(s)
    AK293239, BC010858, BU953788, CN283479
    Consensus CDS
    CCDS56518.1
    UniProtKB/Swiss-Prot
    Q15910
    Related
    ENSP00000419856.1, ENST00000483967.5
    Conserved Domains (4) summary
    cd19218
    Location:600719
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:550581
    preSET_CXC; CXC domain
  3. NM_001203249.2NP_001190178.1  histone-lysine N-methyltransferase EZH2 isoform e

    See identical proteins and their annotated locations for NP_001190178.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' UTR exon and lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. The resulting isoform (e) lacks three internal segments, as compared to isoform a.
    Source sequence(s)
    AK302216, BC010858, BU953788
    Consensus CDS
    CCDS56517.1
    UniProtKB/Swiss-Prot
    Q15910
    Related
    ENSP00000419050.1, ENST00000476773.5
    Conserved Domains (4) summary
    cd19218
    Location:558677
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:508539
    preSET_CXC; CXC domain
  4. NM_004456.5NP_004447.2  histone-lysine N-methyltransferase EZH2 isoform a

    See identical proteins and their annotated locations for NP_004447.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC010858, BU953788, CN283479
    Consensus CDS
    CCDS5891.1
    UniProtKB/Swiss-Prot
    Q15910
    UniProtKB/TrEMBL
    A0A090N8E9
    Related
    ENSP00000320147.2, ENST00000320356.7
    Conserved Domains (4) summary
    cd19218
    Location:614733
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:564595
    preSET_CXC; CXC domain
  5. NM_152998.3NP_694543.1  histone-lysine N-methyltransferase EZH2 isoform b

    See identical proteins and their annotated locations for NP_694543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon and an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (b) lacks two internal segments, as compared to isoform a.
    Source sequence(s)
    AK314291, BC010858, BU953788, CN283479
    Consensus CDS
    CCDS5892.1
    UniProtKB/Swiss-Prot
    Q15910
    UniProtKB/TrEMBL
    S4S3R8
    Related
    ENSP00000223193.2, ENST00000350995.6
    Conserved Domains (4) summary
    cd19218
    Location:570689
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:119210
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:520551
    preSET_CXC; CXC domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    148807383..148884291 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420002.1XP_047275958.1  histone-lysine N-methyltransferase EZH2 isoform X23

  2. XM_017011820.3XP_016867309.1  histone-lysine N-methyltransferase EZH2 isoform X21

    Conserved Domains (4) summary
    cd19218
    Location:566685
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:110201
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:516547
    preSET_CXC; CXC domain
  3. XM_011515887.4XP_011514189.1  histone-lysine N-methyltransferase EZH2 isoform X8

    See identical proteins and their annotated locations for XP_011514189.1

    Conserved Domains (4) summary
    cd19218
    Location:605724
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:555586
    preSET_CXC; CXC domain
  4. XM_047420004.1XP_047275960.1  histone-lysine N-methyltransferase EZH2 isoform X25

    UniProtKB/TrEMBL
    F2YMM1
  5. XM_011515894.3XP_011514196.1  histone-lysine N-methyltransferase EZH2 isoform X15

    See identical proteins and their annotated locations for XP_011514196.1

    Conserved Domains (4) summary
    cd19218
    Location:575694
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:119210
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:525556
    preSET_CXC; CXC domain
  6. XM_047420001.1XP_047275957.1  histone-lysine N-methyltransferase EZH2 isoform X20

  7. XM_047419999.1XP_047275955.1  histone-lysine N-methyltransferase EZH2 isoform X18

  8. XM_047419990.1XP_047275946.1  histone-lysine N-methyltransferase EZH2 isoform X2

  9. XM_047419997.1XP_047275953.1  histone-lysine N-methyltransferase EZH2 isoform X10

  10. XM_047419992.1XP_047275948.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/Swiss-Prot
    Q96FI6
  11. XM_047419993.1XP_047275949.1  histone-lysine N-methyltransferase EZH2 isoform X6

  12. XM_047419998.1XP_047275954.1  histone-lysine N-methyltransferase EZH2 isoform X14

  13. XM_011515883.3XP_011514185.1  histone-lysine N-methyltransferase EZH2 isoform X1

    See identical proteins and their annotated locations for XP_011514185.1

    Conserved Domains (2) summary
    smart00317
    Location:625746
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  14. XM_047419994.1XP_047275950.1  histone-lysine N-methyltransferase EZH2 isoform X6

  15. XM_005249962.5XP_005250019.1  histone-lysine N-methyltransferase EZH2 isoform X2

    See identical proteins and their annotated locations for XP_005250019.1

    Conserved Domains (4) summary
    cd19218
    Location:617736
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:4776
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:166257
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:567598
    preSET_CXC; CXC domain
  16. XM_047419989.1XP_047275945.1  histone-lysine N-methyltransferase EZH2 isoform X1

  17. XM_047419991.1XP_047275947.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A090N8E9
  18. XM_047420000.1XP_047275956.1  histone-lysine N-methyltransferase EZH2 isoform X19

  19. XM_011515895.3XP_011514197.1  histone-lysine N-methyltransferase EZH2 isoform X17

    Conserved Domains (2) summary
    smart00317
    Location:577698
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  20. XM_005249964.5XP_005250021.1  histone-lysine N-methyltransferase EZH2 isoform X22

    See identical proteins and their annotated locations for XP_005250021.1

    Conserved Domains (2) summary
    smart00317
    Location:569690
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  21. XM_005249963.5XP_005250020.1  histone-lysine N-methyltransferase EZH2 isoform X6

    See identical proteins and their annotated locations for XP_005250020.1

    Conserved Domains (4) summary
    cd19218
    Location:608727
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:4776
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:157248
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:558589
    preSET_CXC; CXC domain
  22. XM_011515885.3XP_011514187.1  histone-lysine N-methyltransferase EZH2 isoform X4

    Conserved Domains (4) summary
    cd19218
    Location:613732
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:4776
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:157248
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:563594
    preSET_CXC; CXC domain
  23. XM_011515896.3XP_011514198.1  histone-lysine N-methyltransferase EZH2 isoform X24

    See identical proteins and their annotated locations for XP_011514198.1

    Conserved Domains (2) summary
    smart00317
    Location:539660
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  24. XM_011515893.3XP_011514195.1  histone-lysine N-methyltransferase EZH2 isoform X14

    See identical proteins and their annotated locations for XP_011514195.1

    Conserved Domains (2) summary
    smart00317
    Location:581702
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  25. XM_011515890.3XP_011514192.1  histone-lysine N-methyltransferase EZH2 isoform X12

    Conserved Domains (2) summary
    smart00317
    Location:586707
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  26. XM_017011819.2XP_016867308.1  histone-lysine N-methyltransferase EZH2 isoform X16

    Conserved Domains (2) summary
    smart00317
    Location:578699
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  27. XM_011515892.3XP_011514194.1  histone-lysine N-methyltransferase EZH2 isoform X13

    See identical proteins and their annotated locations for XP_011514194.1

    Conserved Domains (2) summary
    smart00317
    Location:583704
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  28. XM_017011817.3XP_016867306.1  histone-lysine N-methyltransferase EZH2 isoform X1

    Conserved Domains (2) summary
    smart00317
    Location:625746
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  29. XM_011515889.3XP_011514191.1  histone-lysine N-methyltransferase EZH2 isoform X11

    Conserved Domains (3) summary
    cd19218
    Location:592711
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam18118
    Location:136227
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:542573
    preSET_CXC; CXC domain
  30. XM_047419996.1XP_047275952.1  histone-lysine N-methyltransferase EZH2 isoform X9

  31. XM_047419995.1XP_047275951.1  histone-lysine N-methyltransferase EZH2 isoform X7

  32. XM_047420005.1XP_047275961.1  histone-lysine N-methyltransferase EZH2 isoform X26

  33. XM_047420006.1XP_047275962.1  histone-lysine N-methyltransferase EZH2 isoform X26

  34. XM_011515901.4XP_011514203.1  histone-lysine N-methyltransferase EZH2 isoform X29

    See identical proteins and their annotated locations for XP_011514203.1

    Conserved Domains (1) summary
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  35. XM_047420008.1XP_047275964.1  histone-lysine N-methyltransferase EZH2 isoform X29

  36. XM_047420007.1XP_047275963.1  histone-lysine N-methyltransferase EZH2 isoform X28

  37. XM_011515899.4XP_011514201.1  histone-lysine N-methyltransferase EZH2 isoform X27

    Conserved Domains (1) summary
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  38. XM_047420009.1XP_047275965.1  histone-lysine N-methyltransferase EZH2 isoform X30

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    149989157..150066070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)