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EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Homo sapiens (human) ]

Gene ID: 2146, updated on 16-Sep-2018

Summary

Official Symbol
EZH2provided by HGNC
Official Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by HGNC
Primary source
HGNC:HGNC:3527
See related
Ensembl:ENSG00000106462 MIM:601573; Vega:OTTHUMG00000158973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A
Summary
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.6) and 14 other tissues See more
Orthologs

Genomic context

See EZH2 in Genome Data Viewer
Location:
7q36.1
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (148807372..148884349, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148504464..148581441, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 13 pseudogene Neighboring gene cullin 1 Neighboring gene RNA, U7 small nuclear 20 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 569, pseudogene Neighboring gene RNA, Ro-associated Y5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies enhancer of zeste homolog 2 (EZH2) is important for HIV-1 replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces EZH2 phophorylation in an Akt1 dependent manner PubMed
tat HIV-1 Tat decreases EZH2 levels on the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activation of HOX genes during differentiation, organism-specific biosystem (from REACTOME)
    Activation of HOX genes during differentiation, organism-specific biosystemHox genes encode proteins that contain the DNA-binding homeobox motif and control early patterning of segments in the embryo as well as later events in development (reviewed in Rezsohazy et al. 2015)...
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystem (from REACTOME)
    Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystemIn mammals, anterior Hox genes may be defined as paralog groups 1 to 4 (Natale et al. 2011), which are involved in development of the hindbrain through sequential expression in the rhombomeres, trans...
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Histone Modifications, organism-specific biosystem (from WikiPathways)
    Histone Modifications, organism-specific biosystemHistones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the en...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Interactome of polycomb repressive complex 2 (PRC2), organism-specific biosystem (from WikiPathways)
    Interactome of polycomb repressive complex 2 (PRC2), organism-specific biosystemA proposed interactome of Polycomb repressive complex 2 (PRC2), based on proteomics.
  • Lysine degradation, organism-specific biosystem (from KEGG)
    Lysine degradation, organism-specific biosystem
    Lysine degradation
  • Lysine degradation, conserved biosystem (from KEGG)
    Lysine degradation, conserved biosystem
    Lysine degradation
  • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
    MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    Oxidative Stress Induced Senescence, organism-specific biosystemOxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al...
  • PKMTs methylate histone lysines, organism-specific biosystem (from REACTOME)
    PKMTs methylate histone lysines, organism-specific biosystemLysine methyltransferases (KMTs) and arginine methyltransferases (RMTs) have a common mechanism of catalysis. Both families transfer a methyl group from a common donor, S-adenosyl-L-methionine (SAM),...
  • PRC2 methylates histones and DNA, organism-specific biosystem (from REACTOME)
    PRC2 methylates histones and DNA, organism-specific biosystemPolycomb group proteins are responsible for the heritable repression of genes during development (Lee et al. 2006, Ku et al. 2008, reviewed in Simon and Kingston 2009, Margueron and Reinberg 2011, Di...
  • miRs in Muscle Cell Differentiation, organism-specific biosystem (from WikiPathways)
    miRs in Muscle Cell Differentiation, organism-specific biosystem
    miRs in Muscle Cell Differentiation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9169

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone methyltransferase activity (H3-K27 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone methyltransferase activity (H3-K27 specific) TAS
Traceable Author Statement
more info
PubMed 
histone-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
primary miRNA binding IEA
Inferred from Electronic Annotation
more info
 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA methylation IEA
Inferred from Electronic Annotation
more info
 
G1 to G0 transition IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to trichostatin A IEA
Inferred from Electronic Annotation
more info
 
cerebellar cortex development IEA
Inferred from Electronic Annotation
more info
 
chromatin organization TAS
Traceable Author Statement
more info
PubMed 
hepatocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
histone H3-K27 methylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-K27 trimethylation IEA
Inferred from Electronic Annotation
more info
 
histone methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver regeneration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression, epigenetic IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
negative regulation of retinoic acid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription elongation from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell cycle G1/S phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to chromatin IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gliogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to tetrachloromethane IEA
Inferred from Electronic Annotation
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pronucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone-lysine N-methyltransferase EZH2
Names
enhancer of zeste homolog 2
lysine N-methyltransferase 6
NP_001190176.1
NP_001190177.1
NP_001190178.1
NP_004447.2
NP_694543.1
XP_005250019.1
XP_005250020.1
XP_005250021.1
XP_011514185.1
XP_011514186.1
XP_011514187.1
XP_011514188.1
XP_011514189.1
XP_011514190.1
XP_011514191.1
XP_011514192.1
XP_011514193.1
XP_011514194.1
XP_011514195.1
XP_011514196.1
XP_011514197.1
XP_011514198.1
XP_011514199.1
XP_011514200.1
XP_011514201.1
XP_011514203.1
XP_016867306.1
XP_016867307.1
XP_016867308.1
XP_016867309.1
XP_016867310.1
XP_024302448.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032043.1 RefSeqGene

    Range
    5001..81978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_531

mRNA and Protein(s)

  1. NM_001203247.1NP_001190176.1  histone-lysine N-methyltransferase EZH2 isoform c

    See identical proteins and their annotated locations for NP_001190176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (c) lacks one internal segment, as compared to isoform a.
    Source sequence(s)
    BC010858, BU953788, CN283479, U61145
    Consensus CDS
    CCDS56516.1
    UniProtKB/Swiss-Prot
    Q15910
    Related
    ENSP00000419711.1, OTTHUMP00000213780, ENST00000460911.5, OTTHUMT00000352744
    Conserved Domains (2) summary
    smart00317
    Location:612733
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  2. NM_001203248.1NP_001190177.1  histone-lysine N-methyltransferase EZH2 isoform d

    See identical proteins and their annotated locations for NP_001190177.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame segments in the coding region, as compared to variant 1. The resulting isoform (d) lacks two internal segments, as compared to isoform a.
    Source sequence(s)
    AK293239, BC010858, BU953788, CN283479
    Consensus CDS
    CCDS56518.1
    UniProtKB/Swiss-Prot
    Q15910
    Related
    ENSP00000419856.1, OTTHUMP00000213774, ENST00000483967.5, OTTHUMT00000352737
    Conserved Domains (2) summary
    smart00317
    Location:603724
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  3. NM_001203249.1NP_001190178.1  histone-lysine N-methyltransferase EZH2 isoform e

    See identical proteins and their annotated locations for NP_001190178.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' UTR exon and lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. The resulting isoform (e) lacks three internal segments, as compared to isoform a.
    Source sequence(s)
    AK302216, BC010858, BU953788
    Consensus CDS
    CCDS56517.1
    UniProtKB/Swiss-Prot
    Q15910
    Related
    ENSP00000419050.1, OTTHUMP00000213779, ENST00000476773.5, OTTHUMT00000352743
    Conserved Domains (2) summary
    smart00317
    Location:561682
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  4. NM_004456.4NP_004447.2  histone-lysine N-methyltransferase EZH2 isoform a

    See identical proteins and their annotated locations for NP_004447.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC010858, BU953788, CN283479
    Consensus CDS
    CCDS5891.1
    UniProtKB/Swiss-Prot
    Q15910
    UniProtKB/TrEMBL
    A0A090N8E9
    Related
    ENSP00000320147.2, OTTHUMP00000213776, ENST00000320356.6, OTTHUMT00000352740
    Conserved Domains (2) summary
    smart00317
    Location:617738
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  5. NM_152998.2NP_694543.1  histone-lysine N-methyltransferase EZH2 isoform b

    See identical proteins and their annotated locations for NP_694543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon and an in-frame segment in the coding region, as compared to variant 1. The resulting isoform (b) lacks two internal segments, as compared to isoform a.
    Source sequence(s)
    AK314291, BC010858, BU953788, CN283479
    Consensus CDS
    CCDS5892.1
    UniProtKB/Swiss-Prot
    Q15910
    UniProtKB/TrEMBL
    S4S3R8
    Related
    ENSP00000223193.2, OTTHUMP00000214051, ENST00000350995.6, OTTHUMT00000353255
    Conserved Domains (2) summary
    smart00317
    Location:573694
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    148807372..148884349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446680.1XP_024302448.1  histone-lysine N-methyltransferase EZH2 isoform X14

    Conserved Domains (1) summary
    smart00317
    Location:579700
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  2. XM_017011818.1XP_016867307.1  histone-lysine N-methyltransferase EZH2 isoform X8

    Conserved Domains (1) summary
    smart00317
    Location:604725
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  3. XM_017011821.1XP_016867310.1  histone-lysine N-methyltransferase EZH2 isoform X22

    Conserved Domains (1) summary
    smart00317
    Location:503624
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  4. XM_011515892.2XP_011514194.1  histone-lysine N-methyltransferase EZH2 isoform X12

    See identical proteins and their annotated locations for XP_011514194.1

    Conserved Domains (2) summary
    smart00317
    Location:583704
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  5. XM_005249964.4XP_005250021.1  histone-lysine N-methyltransferase EZH2 isoform X19

    See identical proteins and their annotated locations for XP_005250021.1

    Conserved Domains (2) summary
    smart00317
    Location:569690
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  6. XM_011515896.2XP_011514198.1  histone-lysine N-methyltransferase EZH2 isoform X20

    See identical proteins and their annotated locations for XP_011514198.1

    Conserved Domains (2) summary
    smart00317
    Location:539660
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  7. XM_017011819.1XP_016867308.1  histone-lysine N-methyltransferase EZH2 isoform X16

    Conserved Domains (2) summary
    smart00317
    Location:578699
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  8. XM_005249963.4XP_005250020.1  histone-lysine N-methyltransferase EZH2 isoform X5

    See identical proteins and their annotated locations for XP_005250020.1

    Conserved Domains (2) summary
    smart00317
    Location:611732
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  9. XM_011515893.2XP_011514195.1  histone-lysine N-methyltransferase EZH2 isoform X13

    See identical proteins and their annotated locations for XP_011514195.1

    Conserved Domains (2) summary
    smart00317
    Location:581702
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  10. XM_005249962.4XP_005250019.1  histone-lysine N-methyltransferase EZH2 isoform X2

    See identical proteins and their annotated locations for XP_005250019.1

    Conserved Domains (2) summary
    smart00317
    Location:620741
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  11. XM_017011820.2XP_016867309.1  histone-lysine N-methyltransferase EZH2 isoform X18

    Conserved Domains (2) summary
    smart00317
    Location:569690
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  12. XM_011515887.3XP_011514189.1  histone-lysine N-methyltransferase EZH2 isoform X7

    See identical proteins and their annotated locations for XP_011514189.1

    Conserved Domains (2) summary
    smart00317
    Location:608729
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  13. XM_011515891.3XP_011514193.1  histone-lysine N-methyltransferase EZH2 isoform X11

    Conserved Domains (1) summary
    smart00317
    Location:584705
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  14. XM_011515886.2XP_011514188.1  histone-lysine N-methyltransferase EZH2 isoform X6

    See identical proteins and their annotated locations for XP_011514188.1

    Conserved Domains (1) summary
    smart00317
    Location:609730
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  15. XM_011515897.2XP_011514199.1  histone-lysine N-methyltransferase EZH2 isoform X21

    See identical proteins and their annotated locations for XP_011514199.1

    Conserved Domains (1) summary
    smart00317
    Location:508629
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  16. XM_011515894.2XP_011514196.1  histone-lysine N-methyltransferase EZH2 isoform X15

    See identical proteins and their annotated locations for XP_011514196.1

    Conserved Domains (2) summary
    smart00317
    Location:578699
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  17. XM_011515898.2XP_011514200.1  histone-lysine N-methyltransferase EZH2 isoform X21

    See identical proteins and their annotated locations for XP_011514200.1

    Conserved Domains (1) summary
    smart00317
    Location:508629
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  18. XM_011515883.2XP_011514185.1  histone-lysine N-methyltransferase EZH2 isoform X1

    See identical proteins and their annotated locations for XP_011514185.1

    Conserved Domains (2) summary
    smart00317
    Location:625746
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  19. XM_011515888.2XP_011514190.1  histone-lysine N-methyltransferase EZH2 isoform X7

    See identical proteins and their annotated locations for XP_011514190.1

    Conserved Domains (2) summary
    smart00317
    Location:608729
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  20. XM_011515884.2XP_011514186.1  histone-lysine N-methyltransferase EZH2 isoform X3

    See identical proteins and their annotated locations for XP_011514186.1

    UniProtKB/Swiss-Prot
    Q15910
    UniProtKB/TrEMBL
    A0A090N8E9
    Conserved Domains (2) summary
    smart00317
    Location:617738
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:3967
    EZH2_WD-Binding; WD repeat binding protein EZH2
  21. XM_011515895.2XP_011514197.1  histone-lysine N-methyltransferase EZH2 isoform X17

    Conserved Domains (2) summary
    smart00317
    Location:577698
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  22. XM_011515885.2XP_011514187.1  histone-lysine N-methyltransferase EZH2 isoform X4

    Conserved Domains (2) summary
    smart00317
    Location:616737
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  23. XM_011515890.2XP_011514192.1  histone-lysine N-methyltransferase EZH2 isoform X10

    Conserved Domains (2) summary
    smart00317
    Location:586707
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  24. XM_017011817.2XP_016867306.1  histone-lysine N-methyltransferase EZH2 isoform X1

    Conserved Domains (2) summary
    smart00317
    Location:625746
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  25. XM_011515889.2XP_011514191.1  histone-lysine N-methyltransferase EZH2 isoform X9

    Conserved Domains (1) summary
    smart00317
    Location:595716
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
  26. XM_011515901.3XP_011514203.1  histone-lysine N-methyltransferase EZH2 isoform X24

    See identical proteins and their annotated locations for XP_011514203.1

    Conserved Domains (1) summary
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2
  27. XM_011515899.3XP_011514201.1  histone-lysine N-methyltransferase EZH2 isoform X23

    Conserved Domains (1) summary
    pfam11616
    Location:4775
    EZH2_WD-Binding; WD repeat binding protein EZH2

RNA

  1. XR_002956414.1 RNA Sequence

  2. XR_002956413.1 RNA Sequence

  3. XR_001744581.1 RNA Sequence

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