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Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 14056, updated on 1-Mar-2024

Summary

Official Symbol
Ezh2provided by MGI
Official Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by MGI
Primary source
MGI:MGI:107940
See related
Ensembl:ENSMUSG00000029687 AllianceGenome:MGI:107940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KMT6; Enx-1; Enx1h; mKIAA4065
Summary
Enables several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in B cell differentiation; cell development; and regulation of circadian rhythm. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; bone cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 46.4), CNS E14 (RPKM 30.5) and 11 other tissues See more
Orthologs
NEW
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Genomic context

See Ezh2 in Genome Data Viewer
Location:
6 B2.3; 6 22.92 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47507208..47613843, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47530274..47595270, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TAR (HIV) RNA binding protein 2 pseudogene Neighboring gene cullin 1 Neighboring gene STARR-seq mESC enhancer starr_15778 Neighboring gene RIKEN cDNA F830010H11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:47544952-47545253 Neighboring gene STARR-seq mESC enhancer starr_15780 Neighboring gene STARR-seq mESC enhancer starr_15781 Neighboring gene STARR-positive B cell enhancer ABC_E4823 Neighboring gene predicted gene, 40371 Neighboring gene predicted gene, 40369 Neighboring gene 4.5S RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4065, MGC90723

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II core promoter sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K27 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone H3K27 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables histone H3K27 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K27 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables lncRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables primary miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within G1 to G0 transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to trichostatin A IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in facultative heterochromatin formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hepatocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in immunoglobulin heavy chain V-D-J recombination TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of striated muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to tetrachloromethane IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in subtelomeric heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in pronucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone-lysine N-methyltransferase EZH2
Names
enhancer of zeste homolog 2
NP_001140161.1
NP_001396739.1
NP_001396740.1
NP_001396741.1
NP_001396742.1
NP_001396743.1
NP_001396744.1
NP_001396745.1
NP_001396746.1
NP_001396747.1
NP_001396748.1
NP_001396749.1
NP_001396750.1
NP_001396751.1
NP_001396752.1
NP_001396753.1
NP_001396754.1
NP_001396755.1
NP_001396756.1
NP_001396757.1
NP_001396758.1
NP_001396759.1
NP_001396760.1
NP_031997.2
XP_006505590.1
XP_030111015.1
XP_036021710.1
XP_036021711.1
XP_036021712.1
XP_036021713.1
XP_036021715.1
XP_036021716.1
XP_036021720.1
XP_036021721.1
XP_036021722.1
XP_036021724.1
XP_036021725.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146689.1NP_001140161.1  histone-lysine N-methyltransferase EZH2 isoform 2

    See identical proteins and their annotated locations for NP_001140161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK157853, AK220174, BC079538
    Consensus CDS
    CCDS51760.1
    UniProtKB/TrEMBL
    Q3TZH6, Q6AXH7
    Related
    ENSMUSP00000110265.2, ENSMUST00000114618.8
    Conserved Domains (4) summary
    cd19218
    Location:605724
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:555586
    preSET_CXC; CXC domain
  2. NM_001409810.1NP_001396739.1  histone-lysine N-methyltransferase EZH2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  3. NM_001409811.1NP_001396740.1  histone-lysine N-methyltransferase EZH2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  4. NM_001409812.1NP_001396741.1  histone-lysine N-methyltransferase EZH2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  5. NM_001409813.1NP_001396742.1  histone-lysine N-methyltransferase EZH2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/Swiss-Prot
    Q61188, Q99L74, Q9R090
    UniProtKB/TrEMBL
    Q3TZH6
  6. NM_001409814.1NP_001396743.1  histone-lysine N-methyltransferase EZH2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/Swiss-Prot
    Q61188, Q99L74, Q9R090
    UniProtKB/TrEMBL
    Q3TZH6
  7. NM_001409815.1NP_001396744.1  histone-lysine N-methyltransferase EZH2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/Swiss-Prot
    Q61188, Q99L74, Q9R090
    UniProtKB/TrEMBL
    Q3TZH6
  8. NM_001409816.1NP_001396745.1  histone-lysine N-methyltransferase EZH2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/Swiss-Prot
    Q61188, Q99L74, Q9R090
    UniProtKB/TrEMBL
    Q3TZH6
  9. NM_001409817.1NP_001396746.1  histone-lysine N-methyltransferase EZH2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/Swiss-Prot
    Q61188, Q99L74, Q9R090
    UniProtKB/TrEMBL
    Q3TZH6
  10. NM_001409818.1NP_001396747.1  histone-lysine N-methyltransferase EZH2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  11. NM_001409819.1NP_001396748.1  histone-lysine N-methyltransferase EZH2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  12. NM_001409820.1NP_001396749.1  histone-lysine N-methyltransferase EZH2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  13. NM_001409821.1NP_001396750.1  histone-lysine N-methyltransferase EZH2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  14. NM_001409822.1NP_001396751.1  histone-lysine N-methyltransferase EZH2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  15. NM_001409823.1NP_001396752.1  histone-lysine N-methyltransferase EZH2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  16. NM_001409824.1NP_001396753.1  histone-lysine N-methyltransferase EZH2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
    Related
    ENSMUSP00000090318.7, ENSMUST00000092648.13
  17. NM_001409825.1NP_001396754.1  histone-lysine N-methyltransferase EZH2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  18. NM_001409826.1NP_001396755.1  histone-lysine N-methyltransferase EZH2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  19. NM_001409827.1NP_001396756.1  histone-lysine N-methyltransferase EZH2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  20. NM_001409828.1NP_001396757.1  histone-lysine N-methyltransferase EZH2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  21. NM_001409829.1NP_001396758.1  histone-lysine N-methyltransferase EZH2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  22. NM_001409830.1NP_001396759.1  histone-lysine N-methyltransferase EZH2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    Q3TZH6
  23. NM_001409831.1NP_001396760.1  histone-lysine N-methyltransferase EZH2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
    UniProtKB/TrEMBL
    D3Z774
  24. NM_007971.2NP_031997.2  histone-lysine N-methyltransferase EZH2 isoform 1

    See identical proteins and their annotated locations for NP_031997.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as ENX-1A.
    Source sequence(s)
    AK157853, AK220174, BC079538
    Consensus CDS
    CCDS20096.1
    UniProtKB/Swiss-Prot
    Q61188, Q99L74, Q9R090
    UniProtKB/TrEMBL
    Q3TZH6
    Related
    ENSMUSP00000080419.7, ENSMUST00000081721.13
    Conserved Domains (4) summary
    cd19218
    Location:609728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559590
    preSET_CXC; CXC domain

RNA

  1. NR_176898.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
  2. NR_176899.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
  3. NR_176900.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
  4. NR_176901.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
  5. NR_176902.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652
  6. NR_176903.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154015, AC155652

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    47507208..47613843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165829.1XP_036021722.1  histone-lysine N-methyltransferase EZH2 isoform X10

    UniProtKB/TrEMBL
    D3Z774
    Conserved Domains (3) summary
    cd19218
    Location:500619
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam18118
    Location:49140
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:450481
    preSET_CXC; CXC domain
  2. XM_036165828.1XP_036021721.1  histone-lysine N-methyltransferase EZH2 isoform X9

    UniProtKB/TrEMBL
    D3Z774
    Conserved Domains (3) summary
    cd19218
    Location:505624
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam18118
    Location:49140
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:455486
    preSET_CXC; CXC domain
  3. XM_036165832.1XP_036021725.1  histone-lysine N-methyltransferase EZH2 isoform X11

    Conserved Domains (2) summary
    cd19218
    Location:377496
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam18264
    Location:327358
    preSET_CXC; CXC domain
  4. XM_030255155.1XP_030111015.1  histone-lysine N-methyltransferase EZH2 isoform X13

    Conserved Domains (2) summary
    pfam18264
    Location:285316
    preSET_CXC; CXC domain
    cd19218
    Location:335454
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
  5. XM_006505527.2XP_006505590.1  histone-lysine N-methyltransferase EZH2 isoform X11

    See identical proteins and their annotated locations for XP_006505590.1

    Conserved Domains (2) summary
    cd19218
    Location:377496
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam18264
    Location:327358
    preSET_CXC; CXC domain
  6. XM_036165827.1XP_036021720.1  histone-lysine N-methyltransferase EZH2 isoform X8

    UniProtKB/TrEMBL
    Q3TZH6
    Conserved Domains (4) summary
    cd19218
    Location:558677
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:508539
    preSET_CXC; CXC domain
  7. XM_036165823.1XP_036021716.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    Q3TZH6, Q6AXH7
    Conserved Domains (4) summary
    cd19218
    Location:605724
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:555586
    preSET_CXC; CXC domain
  8. XM_036165831.1XP_036021724.1  histone-lysine N-methyltransferase EZH2 isoform X11

    Conserved Domains (2) summary
    cd19218
    Location:377496
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam18264
    Location:327358
    preSET_CXC; CXC domain
  9. XM_036165817.1XP_036021710.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    Q3TZH6
    Conserved Domains (4) summary
    cd19218
    Location:614733
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:564595
    preSET_CXC; CXC domain
  10. XM_036165820.1XP_036021713.1  histone-lysine N-methyltransferase EZH2 isoform X2

    UniProtKB/Swiss-Prot
    Q61188, Q99L74, Q9R090
    UniProtKB/TrEMBL
    Q3TZH6
    Conserved Domains (4) summary
    cd19218
    Location:609728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559590
    preSET_CXC; CXC domain
  11. XM_036165818.1XP_036021711.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    Q3TZH6
    Conserved Domains (4) summary
    cd19218
    Location:614733
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:564595
    preSET_CXC; CXC domain
  12. XM_036165822.1XP_036021715.1  histone-lysine N-methyltransferase EZH2 isoform X2

    UniProtKB/Swiss-Prot
    Q61188, Q99L74, Q9R090
    UniProtKB/TrEMBL
    Q3TZH6
    Conserved Domains (4) summary
    cd19218
    Location:609728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559590
    preSET_CXC; CXC domain
  13. XM_036165819.1XP_036021712.1  histone-lysine N-methyltransferase EZH2 isoform X1

    UniProtKB/TrEMBL
    Q3TZH6
    Conserved Domains (4) summary
    cd19218
    Location:614733
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:3968
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:564595
    preSET_CXC; CXC domain