Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ezh2provided by MGI
Official Full Name: enhancer of zeste 2 polycomb repressive complex 2 subunitprovided by MGI
Primary source: MGI:MGI:107940
See related: Ensembl:ENSMUSG00000029687 AllianceGenome:MGI:107940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KMT6; Enx-1; Enx1h; mKIAA4065
Summary: Enables several functions, including histone H3K27 methyltransferase activity; nucleic acid binding activity; and transcription corepressor activity. Involved in B cell differentiation; facultative heterochromatin formation; and regulation of circadian rhythm. Acts upstream of or within several processes, including cardiac muscle hypertrophy in response to stress; negative regulation of cell differentiation; and regulation of DNA-templated transcription. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Weaver syndrome; gastrointestinal system cancer (multiple); glioblastoma; hematologic cancer (multiple); and renal Wilms' tumor. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 46.4), CNS E14 (RPKM 30.5) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B2.3; 6 22.92 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (47507208..47613843, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (47530274..47595270, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunction.
Title: Functional role of lncRNA MEG3 on pyroptosis through interacting with EZH2 and YTHDC1 in postoperative cognitive dysfunction.
Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation.
Title: Hyperactivating EZH2 to augment H3K27me3 levels in regulatory T cells enhances immune suppression by driving early effector differentiation.
LncRNA CARMN facilitates odontogenic differentiation of dental pulp cells by impairing EZH2.
Title: LncRNA CARMN facilitates odontogenic differentiation of dental pulp cells by impairing EZH2.
Tumor-Intrinsic Enhancer of Zeste Homolog 2 Controls Immune Cell Infiltration, Tumor Growth, and Lung Metastasis in a Triple-Negative Breast Cancer Model.
Title: Tumor-Intrinsic Enhancer of Zeste Homolog 2 Controls Immune Cell Infiltration, Tumor Growth, and Lung Metastasis in a Triple-Negative Breast Cancer Model.
Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes.
Title: Stat5b/Ezh2 axis governs high PD-L1 expressing tolerogenic dendritic cell subset in autoimmune diabetes.
Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos.
Title: Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos.
Identification and functional analysis of the hub Ferroptosis-Related gene EZH2 in diabetic kidney disease.
Title: Identification and functional analysis of the hub Ferroptosis-Related gene EZH2 in diabetic kidney disease.
NEAT1 regulates VSMC differentiation and calcification in as long noncoding RNA NEAT1 enhances phenotypic and osteogenic switching of vascular smooth muscle cells in atherosclerosis via scaffolding EZH2.
Title: NEAT1 regulates VSMC differentiation and calcification in as long noncoding RNA NEAT1 enhances phenotypic and osteogenic switching of vascular smooth muscle cells in atherosclerosis via scaffolding EZH2.
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
Title: LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells.
Title: EZH2 inhibition stimulates repetitive element expression and viral mimicry in resting splenic B cells.

Submit: New GeneRIF Correction See all GeneRIFs (332)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC108938P1 (e-PCR)
- UniSTS:257095

AW554728 (e-PCR)
- UniSTS:207946

U52951 (e-PCR)
- UniSTS:125771

D6Mit351 (e-PCR), detects polymorphism
- UniSTS:130902

RH125972 (e-PCR)
- UniSTS:162684

PMC87093P1 (e-PCR)
- UniSTS:273577

Ezh2 (e-PCR), detects polymorphism
- UniSTS:143053

UniSTS:143054 (e-PCR)
- UniSTS:143054

Ezh2 (e-PCR), detects polymorphism
- UniSTS:143054

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II core promoter sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H3K27 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K27 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H3K27 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K27 methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K27 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables histone methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleosome binding	IEA Inferred from Electronic Annotation more info
enables primary miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-lysine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-lysine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	IEA Inferred from Electronic Annotation more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G1 to G0 transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to hydrogen peroxide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to trichostatin A	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in facultative heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in immunoglobulin heavy chain V-D-J recombination	TAS Traceable Author Statement more info	PubMed
acts_upstream_of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retinoic acid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of striated muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell cycle G1/S phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to tetrachloromethane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in subtelomeric heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, GABAergic	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	IDA Inferred from Direct Assay more info	PubMed
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
part_of chromatin silencing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in pronucleus	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase EZH2

Names: enhancer of zeste homolog 2

NP_001140161.1

EC 2.1.1.356

NP_001396739.1

EC 2.1.1.356

NP_001396740.1

EC 2.1.1.356

NP_001396741.1

EC 2.1.1.356

NP_001396742.1

EC 2.1.1.356

NP_001396743.1

EC 2.1.1.356

NP_001396744.1

EC 2.1.1.356

NP_001396745.1

EC 2.1.1.356

NP_001396746.1

EC 2.1.1.356

NP_001396747.1

EC 2.1.1.356

NP_001396748.1

EC 2.1.1.356

NP_001396749.1

EC 2.1.1.356

NP_001396750.1

EC 2.1.1.356

NP_001396751.1

EC 2.1.1.356

NP_001396752.1

EC 2.1.1.356

NP_001396753.1

EC 2.1.1.356

NP_001396754.1

EC 2.1.1.356

NP_001396755.1

EC 2.1.1.356

NP_001396756.1

EC 2.1.1.356

NP_001396757.1

EC 2.1.1.356

NP_001396758.1

EC 2.1.1.356

NP_001396759.1

EC 2.1.1.356

NP_001396760.1

EC 2.1.1.356

NP_031997.2

EC 2.1.1.356

XP_006505590.1

EC 2.1.1.356

XP_030111015.1

EC 2.1.1.356

XP_036021710.1

EC 2.1.1.356

XP_036021711.1

EC 2.1.1.356

XP_036021712.1

EC 2.1.1.356

XP_036021713.1

EC 2.1.1.356

XP_036021715.1

EC 2.1.1.356

XP_036021716.1

EC 2.1.1.356

XP_036021720.1

EC 2.1.1.356

XP_036021721.1

EC 2.1.1.356

XP_036021722.1

EC 2.1.1.356

XP_036021724.1

EC 2.1.1.356

XP_036021725.1

EC 2.1.1.356

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146689.1 → NP_001140161.1 histone-lysine N-methyltransferase EZH2 isoform 2

See identical proteins and their annotated locations for NP_001140161.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK157853, AK220174, BC079538

Consensus CDS

CCDS51760.1

UniProtKB/TrEMBL

Q3TZH6, Q6AXH7

Related

ENSMUSP00000110265.2, ENSMUST00000114618.8

Conserved Domains (4) summary

cd19218
Location:605 → 724

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:555 → 586

preSET_CXC; CXC domain
NM_001409810.1 → NP_001396739.1 histone-lysine N-methyltransferase EZH2 isoform 3

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409811.1 → NP_001396740.1 histone-lysine N-methyltransferase EZH2 isoform 3

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409812.1 → NP_001396741.1 histone-lysine N-methyltransferase EZH2 isoform 3

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409813.1 → NP_001396742.1 histone-lysine N-methyltransferase EZH2 isoform 1

Status: VALIDATED

Source sequence(s)

AC154015, AC155652

UniProtKB/Swiss-Prot

Q61188, Q99L74, Q9R090
NM_001409814.1 → NP_001396743.1 histone-lysine N-methyltransferase EZH2 isoform 1

Status: VALIDATED

Source sequence(s)

AC154015, AC155652

UniProtKB/Swiss-Prot

Q61188, Q99L74, Q9R090
NM_001409815.1 → NP_001396744.1 histone-lysine N-methyltransferase EZH2 isoform 1

Status: VALIDATED

Source sequence(s)

AC154015, AC155652

UniProtKB/Swiss-Prot

Q61188, Q99L74, Q9R090
NM_001409816.1 → NP_001396745.1 histone-lysine N-methyltransferase EZH2 isoform 1

Status: VALIDATED

Source sequence(s)

AC154015, AC155652

UniProtKB/Swiss-Prot

Q61188, Q99L74, Q9R090
NM_001409817.1 → NP_001396746.1 histone-lysine N-methyltransferase EZH2 isoform 1

Status: VALIDATED

Source sequence(s)

AC154015, AC155652

UniProtKB/Swiss-Prot

Q61188, Q99L74, Q9R090
NM_001409818.1 → NP_001396747.1 histone-lysine N-methyltransferase EZH2 isoform 4

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409819.1 → NP_001396748.1 histone-lysine N-methyltransferase EZH2 isoform 4

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409820.1 → NP_001396749.1 histone-lysine N-methyltransferase EZH2 isoform 4

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409821.1 → NP_001396750.1 histone-lysine N-methyltransferase EZH2 isoform 4

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409822.1 → NP_001396751.1 histone-lysine N-methyltransferase EZH2 isoform 5

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409823.1 → NP_001396752.1 histone-lysine N-methyltransferase EZH2 isoform 6

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409824.1 → NP_001396753.1 histone-lysine N-methyltransferase EZH2 isoform 6

Status: VALIDATED

Source sequence(s)

AC154015, AC155652

Related

ENSMUSP00000090318.7, ENSMUST00000092648.13
NM_001409825.1 → NP_001396754.1 histone-lysine N-methyltransferase EZH2 isoform 6

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409826.1 → NP_001396755.1 histone-lysine N-methyltransferase EZH2 isoform 6

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409827.1 → NP_001396756.1 histone-lysine N-methyltransferase EZH2 isoform 6

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409828.1 → NP_001396757.1 histone-lysine N-methyltransferase EZH2 isoform 6

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409829.1 → NP_001396758.1 histone-lysine N-methyltransferase EZH2 isoform 7

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409830.1 → NP_001396759.1 histone-lysine N-methyltransferase EZH2 isoform 8

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_001409831.1 → NP_001396760.1 histone-lysine N-methyltransferase EZH2 isoform 9

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NM_007971.2 → NP_031997.2 histone-lysine N-methyltransferase EZH2 isoform 1

See identical proteins and their annotated locations for NP_031997.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform is also known as ENX-1A.

Source sequence(s)

AK157853, AK220174, BC079538

Consensus CDS

CCDS20096.1

UniProtKB/Swiss-Prot

Q61188, Q99L74, Q9R090

UniProtKB/TrEMBL

Q3TZH6

Related

ENSMUSP00000080419.7, ENSMUST00000081721.13

Conserved Domains (4) summary

cd19218
Location:609 → 728

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:559 → 590

preSET_CXC; CXC domain

RNA

NR_176898.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NR_176899.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NR_176900.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NR_176901.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NR_176902.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154015, AC155652
NR_176903.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC154015, AC155652

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

47507208..47613843 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165829.1 → XP_036021722.1 histone-lysine N-methyltransferase EZH2 isoform X10

UniProtKB/TrEMBL

D3Z774

Conserved Domains (3) summary

cd19218
Location:500 → 619

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18118
Location:49 → 140

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:450 → 481

preSET_CXC; CXC domain
XM_036165828.1 → XP_036021721.1 histone-lysine N-methyltransferase EZH2 isoform X9

UniProtKB/TrEMBL

D3Z774

Conserved Domains (3) summary

cd19218
Location:505 → 624

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18118
Location:49 → 140

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:455 → 486

preSET_CXC; CXC domain
XM_036165832.1 → XP_036021725.1 histone-lysine N-methyltransferase EZH2 isoform X11

Conserved Domains (2) summary

cd19218
Location:377 → 496

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18264
Location:327 → 358

preSET_CXC; CXC domain
XM_030255155.1 → XP_030111015.1 histone-lysine N-methyltransferase EZH2 isoform X13

Conserved Domains (2) summary

pfam18264
Location:285 → 316

preSET_CXC; CXC domain

cd19218
Location:335 → 454

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
XM_006505527.2 → XP_006505590.1 histone-lysine N-methyltransferase EZH2 isoform X11

See identical proteins and their annotated locations for XP_006505590.1

Conserved Domains (2) summary

cd19218
Location:377 → 496

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18264
Location:327 → 358

preSET_CXC; CXC domain
XM_036165827.1 → XP_036021720.1 histone-lysine N-methyltransferase EZH2 isoform X8

UniProtKB/TrEMBL

Q3TZH6

Conserved Domains (4) summary

cd19218
Location:558 → 677

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:508 → 539

preSET_CXC; CXC domain
XM_036165823.1 → XP_036021716.1 histone-lysine N-methyltransferase EZH2 isoform X3

UniProtKB/TrEMBL

Q3TZH6, Q6AXH7

Conserved Domains (4) summary

cd19218
Location:605 → 724

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:149 → 240

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:555 → 586

preSET_CXC; CXC domain
XM_036165831.1 → XP_036021724.1 histone-lysine N-methyltransferase EZH2 isoform X11

Conserved Domains (2) summary

cd19218
Location:377 → 496

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam18264
Location:327 → 358

preSET_CXC; CXC domain
XM_036165817.1 → XP_036021710.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q3TZH6

Conserved Domains (4) summary

cd19218
Location:614 → 733

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:564 → 595

preSET_CXC; CXC domain
XM_036165820.1 → XP_036021713.1 histone-lysine N-methyltransferase EZH2 isoform X2

UniProtKB/Swiss-Prot

Q61188, Q99L74, Q9R090

UniProtKB/TrEMBL

Q3TZH6

Conserved Domains (4) summary

cd19218
Location:609 → 728

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:559 → 590

preSET_CXC; CXC domain
XM_036165818.1 → XP_036021711.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q3TZH6

Conserved Domains (4) summary

cd19218
Location:614 → 733

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:564 → 595

preSET_CXC; CXC domain
XM_036165822.1 → XP_036021715.1 histone-lysine N-methyltransferase EZH2 isoform X2

UniProtKB/Swiss-Prot

Q61188, Q99L74, Q9R090

UniProtKB/TrEMBL

Q3TZH6

Conserved Domains (4) summary

cd19218
Location:609 → 728

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:559 → 590

preSET_CXC; CXC domain
XM_036165819.1 → XP_036021712.1 histone-lysine N-methyltransferase EZH2 isoform X1

UniProtKB/TrEMBL

Q3TZH6

Conserved Domains (4) summary

cd19218
Location:614 → 733

SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins

pfam11616
Location:39 → 68

EZH2_WD-Binding; WD repeat binding protein EZH2

pfam18118
Location:158 → 249

PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain

pfam18264
Location:564 → 595

preSET_CXC; CXC domain