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VIPR2 vasoactive intestinal peptide receptor 2 [ Homo sapiens (human) ]

Gene ID: 7434, updated on 1-Jun-2020

Summary

Official Symbol
VIPR2provided by HGNC
Official Full Name
vasoactive intestinal peptide receptor 2provided by HGNC
Primary source
HGNC:HGNC:12695
See related
Ensembl:ENSG00000106018 MIM:601970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VPAC2; VPAC2R; VIP-R-2; VPCAP2R; PACAP-R3; DUP7q36.3; PACAP-R-3; C16DUPq36.3
Summary
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Expression
Broad expression in ovary (RPKM 1.9), brain (RPKM 1.9) and 20 other tissues See more
Orthologs

Genomic context

See VIPR2 in Genome Data Viewer
Location:
7q36.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (159028175..159144957, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (158820866..158937649, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene dynein 2 intermediate chain 1 Neighboring gene LINC00689 intron CAGE-defined high expression enhancer Neighboring gene long intergenic non-protein coding RNA 689 Neighboring gene VISTA enhancer hs1753 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 2850

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vasoactive intestinal polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
vasoactive intestinal polypeptide receptor 2
Names
PACAP type III receptor
VIP and PACAP receptor 2
helodermin-preferring VIP receptor
pituitary adenylate cyclase-activating polypeptide type III receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304522.1NP_001291451.1  vasoactive intestinal polypeptide receptor 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001291451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC004863, AK131406, AK308955, KJ534961
    UniProtKB/Swiss-Prot
    P41587
    UniProtKB/TrEMBL
    X5DP12
    Conserved Domains (2) summary
    smart00008
    Location:52118
    HormR; Domain present in hormone receptors
    cl21561
    Location:120291
    7tm_4; Olfactory receptor
  2. NM_001308259.1NP_001295188.1  vasoactive intestinal polypeptide receptor 2 isoform 3

    See identical proteins and their annotated locations for NP_001295188.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC004863, AK131406, CA449700
    Consensus CDS
    CCDS78295.1
    UniProtKB/Swiss-Prot
    P41587
    Related
    ENSP00000366860.3, ENST00000377633.7
    Conserved Domains (1) summary
    pfam00002
    Location:107355
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. NM_003382.5NP_003373.2  vasoactive intestinal polypeptide receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003373.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC004863, AC007269, AF027390, KC877184
    Consensus CDS
    CCDS5950.1
    UniProtKB/Swiss-Prot
    P41587
    UniProtKB/TrEMBL
    X5D7Q6
    Related
    ENSP00000262178.2, ENST00000262178.7
    Conserved Domains (2) summary
    smart00008
    Location:52118
    HormR; Domain present in hormone receptors
    cd15986
    Location:123392
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_130758.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004863, AK308955, U18810

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    159028175..159144957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446914.1XP_024302682.1  vasoactive intestinal polypeptide receptor 2 isoform X2

    Conserved Domains (2) summary
    cd15986
    Location:148417
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
    cl02422
    Location:96143
    HRM; Hormone receptor domain
  2. XM_005249561.3XP_005249618.1  vasoactive intestinal polypeptide receptor 2 isoform X1

    Related
    ENSP00000384497.1, ENST00000402066.5
    Conserved Domains (2) summary
    smart00008
    Location:77143
    HormR; Domain present in hormone receptors
    pfam00002
    Location:148396
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. XM_017012580.1XP_016868069.1  vasoactive intestinal polypeptide receptor 2 isoform X8

    Conserved Domains (2) summary
    cd14964
    Location:2142
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1254
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_024446915.1XP_024302683.1  vasoactive intestinal polypeptide receptor 2 isoform X2

    Conserved Domains (2) summary
    cd15986
    Location:148417
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
    cl02422
    Location:96143
    HRM; Hormone receptor domain
  5. XM_024446918.1XP_024302686.1  vasoactive intestinal polypeptide receptor 2 isoform X8

    Conserved Domains (2) summary
    cd14964
    Location:2142
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1254
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_024446916.1XP_024302684.1  vasoactive intestinal polypeptide receptor 2 isoform X5

    Conserved Domains (2) summary
    cd15986
    Location:123392
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
    cl02422
    Location:71118
    HRM; Hormone receptor domain
  7. XM_024446917.1XP_024302685.1  vasoactive intestinal polypeptide receptor 2 isoform X7

    Conserved Domains (2) summary
    cd15986
    Location:60329
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
    cl02422
    Location:2055
    HRM; Hormone receptor domain
  8. XM_011516550.2XP_011514852.1  vasoactive intestinal polypeptide receptor 2 isoform X4

    Conserved Domains (1) summary
    pfam00002
    Location:107355
    7tm_2; 7 transmembrane receptor (Secretin family)
  9. XM_006716108.3XP_006716171.1  vasoactive intestinal polypeptide receptor 2 isoform X6

    Conserved Domains (2) summary
    pfam00002
    Location:60308
    7tm_2; 7 transmembrane receptor (Secretin family)
    cl02422
    Location:2055
    HRM; Hormone receptor domain
  10. XM_006716107.2XP_006716170.1  vasoactive intestinal polypeptide receptor 2 isoform X3

    Conserved Domains (2) summary
    smart00008
    Location:52118
    HormR; Domain present in hormone receptors
    pfam00002
    Location:123371
    7tm_2; 7 transmembrane receptor (Secretin family)
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