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Vipr2 vasoactive intestinal peptide receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 22355, updated on 18-Apr-2024

Summary

Official Symbol
Vipr2provided by MGI
Official Full Name
vasoactive intestinal peptide receptor 2provided by MGI
Primary source
MGI:MGI:107166
See related
Ensembl:ENSMUSG00000011171 AllianceGenome:MGI:107166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vip2; VPAC2; VPAC2R
Summary
Predicted to enable G protein-coupled peptide receptor activity; peptide hormone binding activity; and vasoactive intestinal polypeptide receptor activity. Predicted to be involved in activation of adenylate cyclase activity; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; and negative regulation of smooth muscle cell proliferation. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cilium. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; retina; and skeleton. Human ortholog(s) of this gene implicated in schizophrenia 16. Orthologous to human VIPR2 (vasoactive intestinal peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 5.1), frontal lobe adult (RPKM 4.1) and 13 other tissues See more
Orthologs
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Genomic context

Location:
12 62.59 cM; 12 F2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (116041040..116117842)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (116077420..116148637)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E923 Neighboring gene zinc finger protein 386 (Kruppel-like) Neighboring gene predicted gene, 53772 Neighboring gene predicted gene, 46383 Neighboring gene predicted gene 20658 Neighboring gene STARR-positive B cell enhancer ABC_E8505 Neighboring gene STARR-seq mESC enhancer starr_33401 Neighboring gene predicted gene, 23732 Neighboring gene predicted gene, 46330

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables vasoactive intestinal polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables vasoactive intestinal polypeptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
vasoactive intestinal polypeptide receptor 2
Names
PACAP type III receptor
PACAP-R-3
PACAP-R3
VIP receptor subtype 2
VIP-R-2
VPAC2 receptor
pituitary adenylate cyclase-activating polypeptide type III receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001422975.1NP_001409904.1  vasoactive intestinal polypeptide receptor 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC105950, AC243430
  2. NM_009511.2NP_033537.1  vasoactive intestinal polypeptide receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033537.1

    Status: VALIDATED

    Source sequence(s)
    AA028630, AI894015, AK038743, BC138572, BU920841, CO044818, D28132
    Consensus CDS
    CCDS26210.1
    UniProtKB/Swiss-Prot
    P41588, P97750
    UniProtKB/TrEMBL
    Q546Q8
    Related
    ENSMUSP00000011315.4, ENSMUST00000011315.10
    Conserved Domains (2) summary
    smart00008
    Location:47117
    HormR; Domain present in hormone receptors
    pfam00002
    Location:122370
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    116041040..116117842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244102.3XP_011242404.1  vasoactive intestinal polypeptide receptor 2 isoform X3

    Conserved Domains (2) summary
    smart00008
    Location:47117
    HormR; Domain present in hormone receptors
    cd15986
    Location:122382
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
  2. XM_017315043.3XP_017170532.1  vasoactive intestinal polypeptide receptor 2 isoform X1

    Conserved Domains (2) summary
    smart00008
    Location:47117
    HormR; Domain present in hormone receptors
    cd15986
    Location:122382
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
  3. XM_006515806.4XP_006515869.1  vasoactive intestinal polypeptide receptor 2 isoform X4

    Conserved Domains (2) summary
    smart00008
    Location:47117
    HormR; Domain present in hormone receptors
    cd15986
    Location:122380
    7tmB1_VIP-R2; vasoactive intestinal polypeptide (VIP) receptor 2, member of the class B family of seven-transmembrane G protein-coupled receptors
  4. XM_017315044.3XP_017170533.1  vasoactive intestinal polypeptide receptor 2 isoform X5

    Conserved Domains (2) summary
    cd14964
    Location:3461
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1222
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily