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VAV2 vav guanine nucleotide exchange factor 2 [ Homo sapiens (human) ]

Gene ID: 7410, updated on 7-Apr-2024

Summary

Official Symbol
VAV2provided by HGNC
Official Full Name
vav guanine nucleotide exchange factor 2provided by HGNC
Primary source
HGNC:HGNC:12658
See related
Ensembl:ENSG00000160293 MIM:600428; AllianceGenome:HGNC:12658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VAV-2
Summary
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in adrenal (RPKM 10.2), small intestine (RPKM 8.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See VAV2 in Genome Data Viewer
Location:
9q34.2
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133761894..133992324, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145977670..146207128, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136627016..136857446, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136519605-136520404 Neighboring gene SARDH intron CAGE-defined T cell enhancer Neighboring gene DBH antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136550530-136551030 Neighboring gene dopamine beta-hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136576505-136577208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136581429-136582130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136580725-136581428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136592563-136593073 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:136608197-136608347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29248 Neighboring gene Sharpr-MPRA regulatory region 10163 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:136640028-136640254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136644953-136645920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136652072-136652624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29250 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136666341-136666861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136667983-136668505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136668506-136669028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136676904-136677659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136677660-136678414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136679171-136679924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29253 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136689618-136690614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136690615-136691612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136699176-136699998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136704646-136705596 Neighboring gene Sharpr-MPRA regulatory region 14277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136715018-136715999 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136714035-136715017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136717779-136718308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136719038-136719538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136719539-136720039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136722620-136723471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136726902-136727725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136727726-136728548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136732543-136733366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136737072-136737572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136737573-136738073 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:136739070-136740269 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136741055-136741790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136741791-136742524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136747665-136748398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136749133-136749866 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:136753100-136754299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136779963-136780912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136780913-136781861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136784581-136785360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136795832-136796480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136809459-136810312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136813513-136814022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136814023-136814532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136815043-136815553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136822320-136822896 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136822897-136823473 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136823474-136824051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136824052-136824628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136825783-136826360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136825207-136825782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136835167-136836051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136836052-136836935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29265 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136843801-136844318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136844835-136845350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136848313-136849057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136853577-136854304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136854305-136855032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136855033-136855760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136855761-136856488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136856489-136857216 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136857945-136858672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20473 Neighboring gene uncharacterized LOC100130548 Neighboring gene BRD3 opposite strand Neighboring gene bromodomain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.
EBI GWAS Catalog
Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation PubMed
Nef nef The C-terminal SH3 domain of Vav binds to the PXXP motif in HIV-1 Nef and this interaction activates Vav and its downstream effectors, leading to morphological changes, cytoskeletal rearrangements, and the activation of the JNK/SAPK cascade PubMed
nef The interaction of HIV-1 Nef with Vav is detected by pull-down assays; mutations in the Nef PXXP motif maintain some residual binding capacity to Vav PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to xenobiotic stimulus TAS
Traceable Author Statement
more info
 
involved_in lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet activation TAS
Traceable Author Statement
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT involved_in regulation of cell size IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cell size IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide exchange factor VAV2
Names
vav 2 oncogene

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029725.1 RefSeqGene

    Range
    5001..235431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134398.2NP_001127870.1  guanine nucleotide exchange factor VAV2 isoform 1

    See identical proteins and their annotated locations for NP_001127870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC033187, BC043615, BC132965, S76992
    Consensus CDS
    CCDS48053.1
    UniProtKB/Swiss-Prot
    A2RUM4, A8MQ12, B6ZDF5, P52735, Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317
    Related
    ENSP00000360916.3, ENST00000371850.8
    Conserved Domains (7) summary
    cd10406
    Location:667769
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:819876
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:389516
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:519576
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein
  2. NM_001411028.1NP_001397957.1  guanine nucleotide exchange factor VAV2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL357934, AL445931, AL590710
    Consensus CDS
    CCDS94524.1
    Related
    ENSP00000360917.1, ENST00000371851.1
  3. NM_003371.4NP_003362.2  guanine nucleotide exchange factor VAV2 isoform 2

    See identical proteins and their annotated locations for NP_003362.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three single exons in the CDS, as compared to variant 1. The reading frame is not changed and the resulting isoform (2) lacks three internal segments, as compared to isoform 1.
    Source sequence(s)
    BC043615, BC132965
    Consensus CDS
    CCDS6979.1
    UniProtKB/Swiss-Prot
    P52735
    Related
    ENSP00000385362.3, ENST00000406606.7
    Conserved Domains (7) summary
    cd10406
    Location:657759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:780837
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    133761894..133992324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015109.2XP_016870598.1  guanine nucleotide exchange factor VAV2 isoform X3

    Conserved Domains (7) summary
    cd10406
    Location:680782
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:832889
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:603662
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384529
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:532589
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein
  2. XM_017015110.2XP_016870599.1  guanine nucleotide exchange factor VAV2 isoform X4

    Conserved Domains (7) summary
    cd10406
    Location:662764
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:814871
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:585644
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:389511
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:514571
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein
  3. XM_017015108.2XP_016870597.1  guanine nucleotide exchange factor VAV2 isoform X2

    Conserved Domains (7) summary
    cd10406
    Location:685787
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:837894
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:608667
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:389534
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:537594
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein
  4. XM_047423845.1XP_047279801.1  guanine nucleotide exchange factor VAV2 isoform X1

  5. XM_017015113.2XP_016870602.1  guanine nucleotide exchange factor VAV2 isoform X5

  6. XM_047423847.1XP_047279803.1  guanine nucleotide exchange factor VAV2 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    145977670..146207128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363748.1XP_054219723.1  guanine nucleotide exchange factor VAV2 isoform X3

  2. XM_054363751.1XP_054219726.1  guanine nucleotide exchange factor VAV2 isoform X8

  3. XM_054363749.1XP_054219724.1  guanine nucleotide exchange factor VAV2 isoform X4

  4. XM_054363750.1XP_054219725.1  guanine nucleotide exchange factor VAV2 isoform X7

  5. XM_054363747.1XP_054219722.1  guanine nucleotide exchange factor VAV2 isoform X2

  6. XM_054363753.1XP_054219728.1  guanine nucleotide exchange factor VAV2 isoform X6

  7. XM_054363752.1XP_054219727.1  guanine nucleotide exchange factor VAV2 isoform X5