2DFK,3ODW,1RJ2,3KZ1,1TXD,1XD4


Conserved Protein Domain Family
RhoGEF

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smart00325: RhoGEF 
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Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.
Statistics
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PSSM-Id: 214619
Aligned: 75 rows
Threshold Bit Score: 75.415
Threshold Setting Gi: 158518386
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DFK_A      45 VINEIMSTERHYIKHLKDICE--GYLKQCR--KRRd-----MFSDEQLKVIFG-NIEDIYRFQ--MGFVRD-----LEK- 106  Norway rat
Q12802    1998 VIYELMQTEFHHVRTLKIMSG--VYSQGMM--ADL------LFEQQMVEKLFP-CLDELISIH--SQFFQR-----ILE- 2058 human
Q12774    1178 VKFELIVSEASYLRSLNIAVD--HFQLSTS--LRA------TLSNQEHQWLFS-RLQDVRDVS--ATFLSD-----LEE- 1238 human
O76572     174 AYFEVITSEASYLRSLNVLIT--HFMASPQ--MLGsksalsVLSDSDRKHLFS-NIFAVRDCS--ERLLCD-----LET- 240  Caenorhabditis e...
Q99434       1 -MFEILTSEFSYQHSLSILVE--EFLQSKE--LRA------TVTQMEHHHLFS-NILDVLGAS--QRFFED-----LEQ- 60   human
Q22354     135 AIWEIVTTEFRYIKLLRYLSNlsFYLTDLQ--NCG------FLKDIENRLVFF-NFVTLFNVNydSLWLQS-----IEP- 199  Caenorhabditis e...
BAA31626   367 VIYELIQTELHHVRTLKIMTR--LFRTGML--EEL------HLEPGVVQGLFP-CVDELSDIH--TRFLSQ-----LLE- 427  human
NP_065682  340 AVWELLHTEASYIRKLRVIIN--LFLCCLLnlQESg-----LLCEVEAERLFS-NIPEIAQLH--RRLWASvmapvLEKa 409  human
BAG62077   211 sLFEVVTSEASYLRSLRLLTD--TFVLS-Q--ALRd-----TLTPRDHHTLFS-NVQRVQGVS--ERFLAT-----LLS- 271  human
NP_592928  234 LLIEMMETESTYVERLRHLVN--DYALPLR--DLAkss-kkLLGLYELNTLFPpCLNKLIQLN--SAFLDE-----FEA- 300  Schizosaccharomy...
Q12802    1998 VIYELMQTEFHHVRTLKIMSG--VYSQGMM--ADL------LFEQQMVEKLFP-CLDELISIH--SQFFQR-----ILE- 2058 human
Q12774    1178 VKFELIVSEASYLRSLNIAVD--HFQLSTS--LRA------TLSNQEHQWLFS-RLQDVRDVS--ATFLSD-----LEE- 1238 human
O76572     174 AYFEVITSEASYLRSLNVLIT--HFMASPQ--MLGsksalsVLSDSDRKHLFS-NIFAVRDCS--ERLLCD-----LET- 240  Caenorhabditis e...
Q99434       1 -MFEILTSEFSYQHSLSILVE--EFLQSKE--LRA------TVTQMEHHHLFS-NILDVLGAS--QRFFED-----LEQ- 60   human
Q22354     135 AIWEIVTTEFRYIKLLRYLSNlsFYLTDLQ--NCG------FLKDIENRLVFF-NFVTLFNVNydSLWLQS-----IEP- 199  Caenorhabditis e...
BAA31626   367 VIYELIQTELHHVRTLKIMTR--LFRTGML--EEL------HLEPGVVQGLFP-CVDELSDIH--TRFLSQ-----LLE- 427  human
NP_065682  340 AVWELLHTEASYIRKLRVIIN--LFLCCLLnlQESg-----LLCEVEAERLFS-NIPEIAQLH--RRLWASvmapvLEKa 409  human
BAG62077   211 sLFEVVTSEASYLRSLRLLTD--TFVLS-Q--ALRd-----TLTPRDHHTLFS-NVQRVQGVS--ERFLAT-----LLS- 271  human
NP_592928  234 LLIEMMETESTYVERLRHLVN--DYALPLR--DLAkss-kkLLGLYELNTLFPpCLNKLIQLN--SAFLDE-----FEA- 300  Schizosaccharomy...
2DFK_A     107 -QYNNDd---------------PHL-------SEIGPCFLEH------QDG-FWIYSEYCNNHLDACMELSK-L-M-KDS 153  Norway rat
Q12802    2059 -RKKESlvdkse----knflikRIG-------DVLVNQFSGEn----aERL-KKTYGKFCGQHNQSVNYFKDl-yA-KDK 2119 human
Q12774    1239 -NFENn----------------IFS-------FQVCDVVLNHa-----PDF-RRVYLPYVTNQTYQERTFQSl-mN-SNS 1286 human
O76572     241 -RLEENlil------------ddIC-------DILSDHFDKH----------FEVYIKYCSNQVYQDRTLRRlK-T-ENP 288  Caenorhabditis e...
Q99434      61 -RHKAq----------------VLV-------EDISDILEEHa-----EKY-FHPYIAYCSNEVYQQRTLQKl-iS-SNA 108  human
Q22354     200 -ILAKSret----------gepLDV-------NYLQNGFRDI------ENW-SRCYTNFHLAHSDSLKHIQKkL-K-ESE 252  Caenorhabditis e...
BAA31626   428 -RRRQAl---------------CPGstrnfviHRLGDLLISQfsgpsaEQM-CKTYSEFCSRHSKALKLYKE-LyA-RDK 488  human
NP_065682  410 rRTRALl---------------QPG-------DFL-KGFKMF------GSL-FKPYIRYCMEEEGCMEYMRG-LlR-DND 457  human
BAG62077   272 -RVRSSp---------------HIS-------D-LCDVVHAH------AVGpFSVYVDYVRNQQYQEETYSR-L-MdTNV 319  human
NP_592928  301 -IMSDLnfedidekkfeeidlrLAC-------CFESHFFAFSqh---yPRY-LEQSNDFGNVLKMASKIP---------- 358  Schizosaccharomy...
Q12802    2059 -RKKESlvdkse----knflikRIG-------DVLVNQFSGEn----aERL-KKTYGKFCGQHNQSVNYFKDl-yA-KDK 2119 human
Q12774    1239 -NFENn----------------IFS-------FQVCDVVLNHa-----PDF-RRVYLPYVTNQTYQERTFQSl-mN-SNS 1286 human
O76572     241 -RLEENlil------------ddIC-------DILSDHFDKH----------FEVYIKYCSNQVYQDRTLRRlK-T-ENP 288  Caenorhabditis e...
Q99434      61 -RHKAq----------------VLV-------EDISDILEEHa-----EKY-FHPYIAYCSNEVYQQRTLQKl-iS-SNA 108  human
Q22354     200 -ILAKSret----------gepLDV-------NYLQNGFRDI------ENW-SRCYTNFHLAHSDSLKHIQKkL-K-ESE 252  Caenorhabditis e...
BAA31626   428 -RRRQAl---------------CPGstrnfviHRLGDLLISQfsgpsaEQM-CKTYSEFCSRHSKALKLYKE-LyA-RDK 488  human
NP_065682  410 rRTRALl---------------QPG-------DFL-KGFKMF------GSL-FKPYIRYCMEEEGCMEYMRG-LlR-DND 457  human
BAG62077   272 -RVRSSp---------------HIS-------D-LCDVVHAH------AVGpFSVYVDYVRNQQYQEETYSR-L-MdTNV 319  human
NP_592928  301 -IMSDLnfedidekkfeeidlrLAC-------CFESHFFAFSqh---yPRY-LEQSNDFGNVLKMASKIP---------- 358  Schizosaccharomy...
2DFK_A     154 RYQHFFEACRLLQQMIdiAIDGFLLTPVQKICKYPLQLAELLKYTAQ--DHSDYRYVAAALAVMRNVTQQINE 224  Norway rat
Q12802    2120 RFQAFVKKKMSSSVVRrlGIPECILLVTQRITKYPVLFQRILQCTKD--NEVEQEDLAQSLSLVKDVIGAVDS 2190 human
Q12774    1287 NFREVLEKLESDPVCQrlSLKSFLILPFQRITRLKLLLQNILKRTQP--GSSEEAEATKAHHALEQLIRDCNN 1357 human
O76572     289 GFLSAVQRLEENKQCQglDMRSFLMLPMQRVTRYPLLLYAILDRITT--TDDRYKTATDALTSSNRVVRDCNE 359  Caenorhabditis elegans
Q99434     109 AFREALREIERRPACGglPMLSFLILPMQRVTRLPLLMDTLCLKTQG--HSERYKAASRALKAISKLVRQCNE 179  human
Q22354     253 NFRDFVTWAEAQENLDrqKLIDTFSVPMQRLTRYNLLLKAVLKVTT---DENEREMISNLVDCAESATAQLNK 322  Caenorhabditis elegans
BAA31626   489 RFQQFIRKVTRPAVLKrhGVQECILLVTQRITKYPLLISRILQHSHG--IEEERQDLTTALGLVKELLSNVDE 559  human
NP_065682  458 LFRAYITWAEKHPQCQrlKLSDMLAKPHQRLTKYPLLLKSVLRKTE---EPRAKEAVVAMIGSVERFIHHVNA 527  human
BAG62077   320 RFSAELRRLQSLPKCErlPLPSFLLLPFQRITRLRMLLQNILRQTEE--GSSRQENAQKALGAVSKIIERCsa 390  human
NP_592928  359 KFVEFHDQVKLNANMNv-GLSQLIMEPVQRIPRYSLFLDQIILLTQEgeCQHTYVRSVEIIKNIAEMPTVDAE 430  Schizosaccharomyces pom...
Q12802    2120 RFQAFVKKKMSSSVVRrlGIPECILLVTQRITKYPVLFQRILQCTKD--NEVEQEDLAQSLSLVKDVIGAVDS 2190 human
Q12774    1287 NFREVLEKLESDPVCQrlSLKSFLILPFQRITRLKLLLQNILKRTQP--GSSEEAEATKAHHALEQLIRDCNN 1357 human
O76572     289 GFLSAVQRLEENKQCQglDMRSFLMLPMQRVTRYPLLLYAILDRITT--TDDRYKTATDALTSSNRVVRDCNE 359  Caenorhabditis elegans
Q99434     109 AFREALREIERRPACGglPMLSFLILPMQRVTRLPLLMDTLCLKTQG--HSERYKAASRALKAISKLVRQCNE 179  human
Q22354     253 NFRDFVTWAEAQENLDrqKLIDTFSVPMQRLTRYNLLLKAVLKVTT---DENEREMISNLVDCAESATAQLNK 322  Caenorhabditis elegans
BAA31626   489 RFQQFIRKVTRPAVLKrhGVQECILLVTQRITKYPLLISRILQHSHG--IEEERQDLTTALGLVKELLSNVDE 559  human
NP_065682  458 LFRAYITWAEKHPQCQrlKLSDMLAKPHQRLTKYPLLLKSVLRKTE---EPRAKEAVVAMIGSVERFIHHVNA 527  human
BAG62077   320 RFSAELRRLQSLPKCErlPLPSFLLLPFQRITRLRMLLQNILRQTEE--GSSRQENAQKALGAVSKIIERCsa 390  human
NP_592928  359 KFVEFHDQVKLNANMNv-GLSQLIMEPVQRIPRYSLFLDQIILLTQEgeCQHTYVRSVEIIKNIAEMPTVDAE 430  Schizosaccharomyces pom...
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