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Vav2 vav 2 oncogene [ Mus musculus (house mouse) ]

Gene ID: 22325, updated on 5-Apr-2024

Summary

Official Symbol
Vav2provided by MGI
Official Full Name
vav 2 oncogeneprovided by MGI
Primary source
MGI:MGI:102718
See related
Ensembl:ENSMUSG00000009621 AllianceGenome:MGI:102718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vav-2; 2810040F13Rik
Summary
This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in spleen adult (RPKM 23.7), duodenum adult (RPKM 17.4) and 28 other tissues See more
Orthologs
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Genomic context

See Vav2 in Genome Data Viewer
Location:
2 A3; 2 19.36 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27152116..27317620, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27262104..27427608, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dopamine beta hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27159262-27159371 Neighboring gene Vav2R10 erythroid cis-regulatory module Neighboring gene Vav2R3 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04000 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27269900-27270101 Neighboring gene STARR-seq mESC enhancer starr_04002 Neighboring gene Vav2R7 erythroid cis-regulatory module Neighboring gene Vav2R5 erythroid cis-regulatory module Neighboring gene bromodomain containing 3, opposite strand Neighboring gene microRNA 7578 Neighboring gene bromodomain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide exchange factor VAV2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009500.2NP_033526.1  guanine nucleotide exchange factor VAV2

    See identical proteins and their annotated locations for NP_033526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AI847175, AL772282, BC053060, U37017
    Consensus CDS
    CCDS15827.1
    UniProtKB/Swiss-Prot
    A2AH49, Q60992
    UniProtKB/TrEMBL
    Q7TSI6
    Related
    ENSMUSP00000062782.8, ENSMUST00000056176.8
    Conserved Domains (8) summary
    cd10406
    Location:657759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:809866
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd00029
    Location:514561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01223
    Location:384506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00169
    Location:401502
    PH; PH domain
    pfam00621
    Location:197370
    RhoGEF; RhoGEF domain
    pfam11971
    Location:18103
    CAMSAP_CH; CAMSAP CH domain

RNA

  1. NR_133905.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon and contains several additional exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI847175, AL772282, BC053060
    Related
    ENSMUST00000185188.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    27152116..27317620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497858.3XP_006497921.1  guanine nucleotide exchange factor VAV2 isoform X4

    See identical proteins and their annotated locations for XP_006497921.1

    UniProtKB/TrEMBL
    Q7TSI6
    Conserved Domains (7) summary
    cd10406
    Location:657759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:780837
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:514561
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01223
    Location:384506
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18103
    CAMSAP_CH; CAMSAP CH domain
  2. XM_006497856.2XP_006497919.1  guanine nucleotide exchange factor VAV2 isoform X2

    UniProtKB/TrEMBL
    Q7TSI6
    Conserved Domains (7) summary
    cd10406
    Location:662764
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:814871
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:585644
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:519566
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01223
    Location:384511
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18103
    CAMSAP_CH; CAMSAP CH domain
  3. XM_006497854.2XP_006497917.1  guanine nucleotide exchange factor VAV2 isoform X1

    UniProtKB/TrEMBL
    Q7TSI6
    Conserved Domains (7) summary
    cd10406
    Location:667769
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:819876
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:524571
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01223
    Location:389516
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18103
    CAMSAP_CH; CAMSAP CH domain
  4. XM_030249470.2XP_030105330.1  guanine nucleotide exchange factor VAV2 isoform X3

    Conserved Domains (7) summary
    cd10406
    Location:662764
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:814871
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:585644
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:202375
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:519566
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01223
    Location:389511
    PH_Vav; Vav pleckstrin homology (PH) domain
    cl00030
    Location:71108
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...