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UQCRB ubiquinol-cytochrome c reductase binding protein [ Homo sapiens (human) ]

Gene ID: 7381, updated on 11-Sep-2019

Summary

Official Symbol
UQCRBprovided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase binding proteinprovided by HGNC
Primary source
HGNC:HGNC:12582
See related
Ensembl:ENSG00000156467 MIM:191330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3
Summary
This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in heart (RPKM 51.3), kidney (RPKM 32.2) and 25 other tissues See more
Orthologs

Genomic context

See UQCRB in Genome Data Viewer
Location:
8q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (96226676..96235634, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (97238904..97247862, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene tubulin beta class I pseudogene 7 Neighboring gene growth differentiation factor 6 Neighboring gene uncharacterized LOC101927039 Neighboring gene mitochondrial transcription termination factor 3 Neighboring gene uncharacterized LOC105375652 Neighboring gene phosphatidylserine synthase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Alzheimer's disease, organism-specific biosystem (from KEGG)
    Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Alzheimer's disease, conserved biosystem (from KEGG)
    Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cytochrome bc1 complex, organism-specific biosystem (from KEGG)
    Cytochrome bc1 complex, organism-specific biosystemStructural complex; Energy metabolism; ATP synthesis
  • Cytochrome bc1 complex, conserved biosystem (from KEGG)
    Cytochrome bc1 complex, conserved biosystemStructural complex; Energy metabolism; ATP synthesis
  • Electron Transport Chain, organism-specific biosystem (from WikiPathways)
    Electron Transport Chain, organism-specific biosystemAn electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O2) to the transfer of H+ ions across a membrane, through a set...
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Oxidative phosphorylation, organism-specific biosystem (from KEGG)
    Oxidative phosphorylation, organism-specific biosystem
    Oxidative phosphorylation
  • Oxidative phosphorylation, conserved biosystem (from KEGG)
    Oxidative phosphorylation, conserved biosystem
    Oxidative phosphorylation
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Respiratory electron transport, organism-specific biosystem (from REACTOME)
    Respiratory electron transport, organism-specific biosystemMitochondria are often described as the "powerhouse" of a cell as it is here that energy is largely released from the oxidation of food. Reducing equivalents generated from beta-oxidation of fatty ac...
  • Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystem (from REACTOME)
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., organism-specific biosystemOxidation of fatty acids and pyruvate in the mitochondrial matrix yield large amounts of NADH. The respiratory electron transport chain couples the re-oxidation of this NADH to NAD+ to the export of ...
  • The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
    The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ92016, FLJ97033

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquinol-cytochrome-c reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
oxidative phosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain TAS
Traceable Author Statement
more info
PubMed 
mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome b-c1 complex subunit 7
Names
complex III subunit 7
complex III subunit VII
mitochondrial ubiquinone-binding protein
ubiquinol-cytochrome c reductase complex 14 kDa protein
ubiquinol-cytochrome c reductase, complex III subunit VI
NP_001186904.1
NP_001241681.1
NP_006285.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008237.1 RefSeqGene

    Range
    5001..13959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199975.2NP_001186904.1  cytochrome b-c1 complex subunit 7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in its 5' UTR, which results in the use of a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AI365233, AK307085, AP003465, BC005230, BI547559
    UniProtKB/Swiss-Prot
    P14927
    Conserved Domains (1) summary
    pfam02271
    Location:174
    UCR_14kD; Ubiquinol-cytochrome C reductase complex 14kD subunit
  2. NM_001254752.1NP_001241681.1  cytochrome b-c1 complex subunit 7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AI365233, AP003465, BI547559, BU535281
    Consensus CDS
    CCDS59107.1
    UniProtKB/Swiss-Prot
    P14927
    Related
    ENSP00000430494.1, ENST00000518406.5
    Conserved Domains (1) summary
    pfam02271
    Location:1086
    UCR_14kD; Ubiquinol-cytochrome C reductase complex 14kD subunit
  3. NM_006294.4NP_006285.1  cytochrome b-c1 complex subunit 7 isoform 1

    See identical proteins and their annotated locations for NP_006285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI365233, AP003465, BC005230, BI547559
    Consensus CDS
    CCDS6269.1
    UniProtKB/Swiss-Prot
    P14927
    Related
    ENSP00000287022.5, ENST00000287022.9
    Conserved Domains (1) summary
    pfam02271
    Location:9106
    UCR_14kD; Ubiquinol-cytochrome C reductase complex 14kD subunit

RNA

  1. NR_045639.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI365233, AK295007, AP003465, BI547559

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    96226676..96235634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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