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Zbtb8a zinc finger and BTB domain containing 8a [ Mus musculus (house mouse) ]

Gene ID: 73680, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb8aprovided by MGI
Official Full Name
zinc finger and BTB domain containing 8aprovided by MGI
Primary source
MGI:MGI:1920930
See related
Ensembl:ENSMUSG00000028807 AllianceGenome:MGI:1920930
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410081M15Rik
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZBTB8A (zinc finger and BTB domain containing 8A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.5), whole brain E14.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb8a in Genome Data Viewer
Location:
4 D2.2; 4 63.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129247425..129271821, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129353632..129378028, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene syncoilin Neighboring gene retinoblastoma binding protein 4, chromatin remodeling factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129012802-129012911 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129013051-129013391 Neighboring gene zinc finger and BTB domain containing 8 opposite strand Neighboring gene STARR-seq mESC enhancer starr_11489 Neighboring gene STARR-seq mESC enhancer starr_11490 Neighboring gene RIKEN cDNA C330020E22 gene Neighboring gene STARR-seq mESC enhancer starr_11493 Neighboring gene STARR-seq mESC enhancer starr_11495 Neighboring gene zinc finger and BTB domain containing 8b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028603.4 → NP_082879.1  zinc finger and BTB domain-containing protein 8A

    See identical proteins and their annotated locations for NP_082879.1

    Status: PROVISIONAL

    Source sequence(s)
    AL607123
    Consensus CDS
    CCDS18690.1
    UniProtKB/Swiss-Prot
    Q8VD30, Q9CWH1
    Related
    ENSMUSP00000030610.3, ENSMUST00000030610.3
    Conserved Domains (5) summary
    smart00225
    Location:25 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:275 → 328
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:277 → 297
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:14 → 119
    BTB; BTB/POZ domain
    pfam13465
    Location:289 → 314
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129247425..129271821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWH1.1 GenPept UniProtKB/Swiss-Prot:Q9CWH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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