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Dhx30 DExH-box helicase 30 [ Mus musculus (house mouse) ]

Gene ID: 72831, updated on 10-Mar-2024

Summary

Official Symbol
Dhx30provided by MGI
Official Full Name
DExH-box helicase 30provided by MGI
Primary source
MGI:MGI:1920081
See related
Ensembl:ENSMUSG00000032480 AllianceGenome:MGI:1920081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HELG; Ddx30; Ret-CoR; 2810477H02Rik; C130058C04Rik
Summary
Enables RNA helicase activity. Involved in central nervous system development. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human DHX30 (DExH-box helicase 30). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 35.3), whole brain E14.5 (RPKM 33.7) and 28 other tissues See more
Orthologs
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Genomic context

See Dhx30 in Genome Data Viewer
Location:
9 F2; 9 59.86 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109913387..109946728, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110084319..110117616, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25250 Neighboring gene STARR-positive B cell enhancer ABC_E9336 Neighboring gene predicted gene 4644 Neighboring gene microtubule-associated protein 4 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25252 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:109964958-109965201 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:109965464-109965647 Neighboring gene STARR-seq mESC enhancer starr_25254 Neighboring gene STARR-positive B cell enhancer ABC_E6806 Neighboring gene predicted gene 10615 Neighboring gene predicted gene, 23377 Neighboring gene STARR-seq mESC enhancer starr_25255 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Neighboring gene STARR-seq mESC enhancer starr_25257

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-quadruplex RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in central nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial large ribosomal subunit assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP-dependent RNA helicase DHX30
Names
DEAH (Asp-Glu-Ala-His) box polypeptide 30
DEAH box protein 30
putative ATP-dependent RNA helicase DHX30
NP_001239611.1
NP_001239612.1
NP_579925.1
XP_006512361.1
XP_006512362.1
XP_006512363.1
XP_006512364.1
XP_006512366.1
XP_006512367.1
XP_006512368.1
XP_006512373.1
XP_017169103.1
XP_017169104.1
XP_030100501.1
XP_030100502.1
XP_030100503.1
XP_030100504.1
XP_030100506.1
XP_030100507.1
XP_036011214.1
XP_036011215.1
XP_036011216.1
XP_036011218.1
XP_036011219.1
XP_036011220.1
XP_036011221.1
XP_036011222.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252682.1NP_001239611.1  ATP-dependent RNA helicase DHX30 isoform 1

    See identical proteins and their annotated locations for NP_001239611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AC159372, AK159601, BY540912, CF724787
    Consensus CDS
    CCDS57706.1
    UniProtKB/TrEMBL
    Q80TP6
    Related
    ENSMUSP00000142549.2, ENSMUST00000197928.5
    Conserved Domains (1) summary
    COG1643
    Location:4231072
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  2. NM_001252683.1NP_001239612.1  ATP-dependent RNA helicase DHX30 isoform 3

    See identical proteins and their annotated locations for NP_001239612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC016202, BY540912, CJ074324
    Consensus CDS
    CCDS57705.1
    UniProtKB/Swiss-Prot
    Q99PU8
    Related
    ENSMUSP00000062622.7, ENSMUST00000062368.13
    Conserved Domains (5) summary
    smart00490
    Location:715814
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:467646
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:886969
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:481622
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:10091131
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
  3. NM_133347.2NP_579925.1  ATP-dependent RNA helicase DHX30 isoform 2

    See identical proteins and their annotated locations for NP_579925.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB047557, BY540912
    Consensus CDS
    CCDS23560.1
    UniProtKB/Swiss-Prot
    Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
    UniProtKB/TrEMBL
    Q80TP6
    Related
    ENSMUSP00000129174.2, ENSMUST00000165596.8
    Conserved Domains (1) summary
    COG1643
    Location:4461095
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    109913387..109946728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512305.5XP_006512368.1  ATP-dependent RNA helicase DHX30 isoform X2

    See identical proteins and their annotated locations for XP_006512368.1

    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4231072
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  2. XM_036155326.1XP_036011219.1  ATP-dependent RNA helicase DHX30 isoform X2

    UniProtKB/TrEMBL
    Q80TP6
    Related
    ENSMUSP00000107622.3, ENSMUST00000111991.9
    Conserved Domains (1) summary
    COG1643
    Location:4231072
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  3. XM_036155325.1XP_036011218.1  ATP-dependent RNA helicase DHX30 isoform X2

    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4231072
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  4. XM_036155328.1XP_036011221.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Related
    ENSMUSP00000143616.2, ENSMUST00000196171.5
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  5. XM_006512301.5XP_006512364.1  ATP-dependent RNA helicase DHX30 isoform X1

    See identical proteins and their annotated locations for XP_006512364.1

    UniProtKB/Swiss-Prot
    Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4461095
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  6. XM_036155329.1XP_036011222.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  7. XM_030244644.2XP_030100504.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  8. XM_006512310.5XP_006512373.1  ATP-dependent RNA helicase DHX30 isoform X3

    See identical proteins and their annotated locations for XP_006512373.1

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  9. XM_036155321.1XP_036011214.1  ATP-dependent RNA helicase DHX30 isoform X1

    UniProtKB/Swiss-Prot
    Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4461095
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  10. XM_036155323.1XP_036011216.1  ATP-dependent RNA helicase DHX30 isoform X2

    UniProtKB/TrEMBL
    Q80TP6
    Related
    ENSMUSP00000142489.2, ENSMUST00000199529.5
    Conserved Domains (1) summary
    COG1643
    Location:4231072
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  11. XM_030244642.2XP_030100502.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  12. XM_006512298.5XP_006512361.1  ATP-dependent RNA helicase DHX30 isoform X1

    See identical proteins and their annotated locations for XP_006512361.1

    UniProtKB/Swiss-Prot
    Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
    UniProtKB/TrEMBL
    Q80TP6
    Related
    ENSMUSP00000142659.2, ENSMUST00000198425.5
    Conserved Domains (1) summary
    COG1643
    Location:4461095
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  13. XM_017313614.2XP_017169103.1  ATP-dependent RNA helicase DHX30 isoform X1

    UniProtKB/Swiss-Prot
    Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4461095
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  14. XM_030244641.2XP_030100501.1  ATP-dependent RNA helicase DHX30 isoform X2

    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4231072
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  15. XM_036155327.1XP_036011220.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  16. XM_006512299.3XP_006512362.1  ATP-dependent RNA helicase DHX30 isoform X1

    See identical proteins and their annotated locations for XP_006512362.1

    UniProtKB/Swiss-Prot
    Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4461095
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  17. XM_030244646.2XP_030100506.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  18. XM_006512303.3XP_006512366.1  ATP-dependent RNA helicase DHX30 isoform X2

    See identical proteins and their annotated locations for XP_006512366.1

    UniProtKB/TrEMBL
    Q80TP6
    Related
    ENSMUSP00000143371.2, ENSMUST00000200066.5
    Conserved Domains (1) summary
    COG1643
    Location:4231072
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  19. XM_017313615.2XP_017169104.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  20. XM_036155322.1XP_036011215.1  ATP-dependent RNA helicase DHX30 isoform X1

    UniProtKB/Swiss-Prot
    Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4461095
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  21. XM_006512300.3XP_006512363.1  ATP-dependent RNA helicase DHX30 isoform X1

    See identical proteins and their annotated locations for XP_006512363.1

    UniProtKB/Swiss-Prot
    Q3U4Z4, Q3UFA0, Q3UJS4, Q91WA7, Q99KN7, Q99PU8
    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4461095
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  22. XM_030244647.1XP_030100507.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  23. XM_006512304.1XP_006512367.1  ATP-dependent RNA helicase DHX30 isoform X2

    See identical proteins and their annotated locations for XP_006512367.1

    UniProtKB/TrEMBL
    Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4231072
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
  24. XM_030244643.1XP_030100503.1  ATP-dependent RNA helicase DHX30 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JGL8, Q80TP6
    Conserved Domains (1) summary
    COG1643
    Location:4151064
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]